Contextual Interference, Engagement , and Change in Motor Performance in Stroke

NCT ID: NCT05342688

Last Updated: 2022-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE1

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-01

Study Completion Date

2023-06-30

Brief Summary

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The aim of the study is to examine associations between contextual interference (CI), engagement during practice and changes in upper limb motor performance among patients post-stroke.

Fifty patients over the age of 18, after a stroke, in the sub-acute and early chronic stages who have weakness of the upper extremity and are treated in a rehabilitation center will be recruited.

The study will include participation in five sessions: session 1 for baseline assessment, session 2-4 for practice of upper extremity functions, and session 5 for post intervention assessment. The intervention will include training of three items from the Wolf motor function test in random order (high CI group) or block order (low CI group). Outcomes of engagement will include the brain engagement index, heart rate variability and galvanic skin response. Outcomes of learning will include the pre-post change in performance of the wolf motor function selected items.

Detailed Description

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The aim of the study is to examine associations between contextual interference (CI), engagement during practice, and changes in upper limb motor performance among patients post-stroke.

Fifty patients over the age of 18, after a stroke, in the sub-acute and early chronic stages who are treated in a rehabilitation center inpatient or outpatient clinics, who have hemiparesis (Fugl-Meyer score = 11-60) will be recruited.

Patients with a history of neurological diseases other than stroke or orthopedics conditions that impair upper extremity function, pain that prevents active movement, hemodynamic instability, cognitive decline and language difficulties that do not allow understanding of instructions and cooperation will be excluded.

The study will include participation in five sessions. In the first session, participants will answer a demographic questionnaire and a set of motor (including the Wolf motor function test), perception and cognitive tests will be delivered. Then participants will be assigned to either high or low CI groups. In the next three sessions, participants will practice three items from the Wolf motor functions test. Participants in the high CI group will practice the items in random order and those in the low CI group will practice the selected items in blocked order. Assessment of outcomes during practice will include assessment of brain engagement index by recording EEG (one electrode) and heart rate variability and galvanic skin response. In the fifth session, at the end of the intervention, a reassessment of the wolf motor function performance will be performed.

Conditions

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Hemiparesis;Poststroke/CVA

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The study will be a randomized controlled trial with a pre-post design.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors
Masking description: The outcome assessor will be blind to the group assignment of the participants. Participants and the investigator who deliver the intervention will be aware of group assignment because it is inherent to the type of practice they receive and deliver respectively.

Study Groups

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High contextual interference

The intervention will involve practicing three items from the Wolf motor function test in random order during three sessions. Each item will be repeated 30 times in total.

Group Type EXPERIMENTAL

Task-specific practice of upper extremity functions

Intervention Type BEHAVIORAL

The intervention will consist of training of items from the Wolf motor function test.

Low contextual interference

The intervention will involve practicing three items from the Wolf motor function test in blocked order during three sessions. Each item will be repeated 30 times in total.

Group Type ACTIVE_COMPARATOR

Task-specific practice of upper extremity functions

Intervention Type BEHAVIORAL

The intervention will consist of training of items from the Wolf motor function test.

Interventions

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Task-specific practice of upper extremity functions

The intervention will consist of training of items from the Wolf motor function test.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Five days to 1-year post-stroke
* Score of 11-60 on the Fugl-Meyer Assessment for upper extremity
* The patient receives physical therapy and/or occupational therapy rehabilitation treatment

Exclusion Criteria

* A history of neurological diseases other than stroke or orthopedics conditions that impair upper extremity function
* Pain that prevents active movement of the upper extremity
* Hemodynamic instability
* Cognitive decline and language difficulties that do not allow understanding of instructions and cooperation.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Reuth Rehabilitation Hospital

OTHER

Sponsor Role collaborator

University of Haifa

OTHER

Sponsor Role lead

Responsible Party

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Michal Kafri, PhD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Reut Medical Center

Tel Aviv, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Michal Kafri, PhD

Role: CONTACT

972586862261

Facility Contacts

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Gadi Bartur, PhD

Role: primary

Other Identifiers

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0012-19-RRH

Identifier Type: -

Identifier Source: org_study_id

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