The Effect of Acute Intermittent Hypoxia on Motor Learning

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-05-27

Study Completion Date

2025-02-24

Brief Summary

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The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.

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Detailed Description

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Conditions

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Incomplete Spinal Cord Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

This study design is twofold. The first study examines the effects of AIH on motor learning using an AIH group and a control group (total N = 30). The second part of this study examines corticospinal indices of motor learning using an AIH group and a SHAM group (i.e., blinded normoxia; total N = 26).

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Repetitive Acute Intermittent Hypoxia

5 consecutive days of 15, 1.5 min episodes at 9% O2 (AIH) alternating with 21% O2 at 1 min intervals

Group Type EXPERIMENTAL

Acute Intermittent Hypoxia

Intervention Type OTHER

5 consecutive days of 15, 1.5 min episodes at 9% O2 (AIH) alternating with 21% O2 at 1 min intervals

SHAM Acute Intermittent Hypoxia

5 consecutive days of 15, 1.5 min episodes at 21% O2 (SHAM AIH) alternating with 21% O2 at 1 min intervals

Group Type SHAM_COMPARATOR

SHAM Acute Intermittent Hypoxia

Intervention Type OTHER

5 consecutive days of 15, 1.5 min episodes at 21% O2 (SHAM AIH) alternating with 21% O2 at 1 min intervals

Control

The control group received no AIH exposure.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Acute Intermittent Hypoxia

5 consecutive days of 15, 1.5 min episodes at 9% O2 (AIH) alternating with 21% O2 at 1 min intervals

Intervention Type OTHER

SHAM Acute Intermittent Hypoxia

5 consecutive days of 15, 1.5 min episodes at 21% O2 (SHAM AIH) alternating with 21% O2 at 1 min intervals

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 to 70 years old (the latter to reduce likelihood of heart disease);
* Medically stable with medical clearance from physician to participate;
* Motor-incomplete spinal cord injuries at or below C2 and at or above L5;
* AIS A-D at initial screen, or other non-traumatic spinal cord injury disorders (e.g. multiple sclerosis, ALS, tumors, acute transverse myelitis, etc.);
* More than 1 year since iSCI to minimize confounds of spontaneous neurological recovery;
* Ability to advance one step overground with or without assistive devices;

Exclusion Criteria

* Severe concurrent illness or pain;
* Recurrent autonomic dysreflexia;
* History of cardiovascular/pulmonary complications;
* Concurrent physical therapy;
* Pregnant at time of enrollment or planning to become pregnant;
* Untreated painful musculoskeletal dysfunction, fracture or pressure sore;
* History of seizures or epilepsy;
* Recurring headaches;
* Concussion within the last six months;
* Depression or manic disorders
* Metal implants in the head, or pacemaker.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes