Intermittent Hypoxia and Upper Extremity EMG Recordings in Individuals With Spinal Cord Injury

NCT ID: NCT05513911

Last Updated: 2022-08-24

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-02-03
• Study Completion Date: 2019-03-25

Brief Summary

In this current study, the examiners examine some of the mechanisms of how Acute Intermittent Hypoxia (AIH) effects the upper extremity of survivors of spinal cord injury. This is accomplished both with the use of a load cell to determine elbow strength changes and high density grid electromyography (EMG) to record bicep muscle activations before and after bouts of AIH

Detailed Description

It has been shown previously that there is an increase in strength in survivors of spinal cord injury after brief bouts of Acute Intermittent Hypoxia. In this study, participants are fitted with a high density EMG electrode on the biceps brachii, and attached to a load cell at the wrist, they are asked to flex and extend their elbow at various levels of intensity. This is performed before and after the 30 minute session of AIH. The investigators hope to identify specific types of motor units of the upper extremity of survivors of spinal cord injury after AIH to help further our understanding of what mechanisms may be causing the known increase in muscle strength post AIH

Conditions

Spinal Cord Injuries

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Acute intermittent Hypoxia Therapy

This group will receive the acute intermittent hypoxia therapy (9% O2) for 30 minutes. Before and after the intervention the participant will perform flexion of the elbow at various levels of intensity

Group Type: EXPERIMENTAL

Acute Intermittent Hypoxia

Intervention Type: OTHER

Acute Intermittent Hypoxia is administered in 30-60 second bouts of 9% O2 concentration, followed by 60-90 seconds of normoxic air concentrations (21% O2, room air). This procedure is repeated 15 times for a 30 minute session

Interventions

Acute Intermittent Hypoxia

Acute Intermittent Hypoxia is administered in 30-60 second bouts of 9% O2 concentration, followed by 60-90 seconds of normoxic air concentrations (21% O2, room air). This procedure is repeated 15 times for a 30 minute session

Intervention Type: OTHER

Other Intervention Names

AIH

Eligibility Criteria

Inclusion Criteria

• History of Spinal Cord Injury from C3-T4
• Non-progressive spinal cord injury
• More than 6 months since initial Spinal Cord injury
• Ability to understand and willingness to sign written informed consent

Exclusion Criteria

• Presence of any of the following medical conditions: Congestive heart failure, arrhythmia, uncontrolled high blood pressure, uncontrolled diabetes mellitus, COPD/emphysema and severe asthma
• Persons with known coronary artery disease, a history of myocardial infarction, or known carotid or intracerebral artery stenosis
• Medical clearance will be required if participant is taking any other investigational agents
• Women who are pregnant or nursing
• Individuals with tracheostomy
• Cannot pursue other research studies which may interfere
• Unable to consent
• Individuals who are not yet adults (infants, children, teenagers)
• Prisoners

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shirley Ryan AbilityLab

OTHER

Sponsor Role: lead

Responsible Party

Milap Sandhu

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

William Z Rymer, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Shirley Ryan AbilityLab

Milap Sandhu, PhD

Role: PRINCIPAL_INVESTIGATOR

Shirley Ryan AbilityLab

Locations

Shirley Ryan AbilityLab

Chicago, Illinois, United States

Countries

United States

Other Identifiers

STU00201602

Identifier Type: -

Identifier Source: org_study_id