Angio-seal VIP Versus Perclose ProGlide for Closure of the Femoral Artery in Peripheral Vascular Disease

NCT ID: NCT05334095

Last Updated: 2022-04-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

1062 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-08-20

Study Completion Date

2022-09-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is designed to evaluate the efficacy (device deployment characteristics and performance) and safety (adverse access site related events) of Perclose ProGlide (Abbott Vascular Devices) for femoral access site closure in patients undergoing peripheral vascular diagnostic and interventional procedures in comparison with Angio-seal VIP (St. Jude Medical).

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Prospective, single-center, randomized (1:1), open-label, non-inferiority study in 1062 patients comparing Perclose ProGlide (test device) to the Angio-seal VIP (standard comparator).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Peripheral Vascular Diseases Percutaneous Intervention Via Femoral Artery

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Perclose ProGlide

Perclose ProGlide 6F Suture-Mediated Closure (SMC) System

Group Type ACTIVE_COMPARATOR

Perclose ProGlide

Intervention Type DEVICE

After peripheral vascular diagnostic and interventional procedures, patients are randomized to receive Perclose ProGlide.

Angio-seal VIP

Angio-seal VIP Vascular Closure Device

Group Type PLACEBO_COMPARATOR

Angio-seal VIP

Intervention Type DEVICE

After peripheral vascular diagnostic and interventional procedures, patients are randomized to receive Angio-seal VIP

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Perclose ProGlide

After peripheral vascular diagnostic and interventional procedures, patients are randomized to receive Perclose ProGlide.

Intervention Type DEVICE

Angio-seal VIP

After peripheral vascular diagnostic and interventional procedures, patients are randomized to receive Angio-seal VIP

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patient is ≥18 and \< 85 years of age.
* Patient is willing to provide written informed consent prior to study device use.
* Patient is undergoing a peripheral vascular diagnostic and/or interventional procedure via femoral arterial access.
* Patients' arterial puncture site is in the common femoral artery confirmed by a femoral angiogram, and ≥10mm away from the ostium of the inferior epigastric artery (IEA) and the bifurcation of superficial femoral artery and the profunda femoris artery.

Exclusion Criteria

* The femoral access site has been punctured within 30 days, or deployed with a collagen-based hemostasis device within 90 days, or a suture-mediated closure device.
* Patients having a hematoma, pseudoaneurysm or arteriovenous fistula present prior to sheath removal confirmed by a femoral angiogram.
* Patients with minimum femoral artery calcium which is fluoroscopically visible at access site or femoral artery diameter stenosis greater than 50%.
* Ankle-brachial index (ABI) of the ipsilateral limb of access site cannot be measured due to severe peripheral artery disease (PAD).
* Patients who are pregnant or lactating.
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Xiongjing Jiang

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Xiongjing Jiang

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Xiongjing Jiang, MD

Role: PRINCIPAL_INVESTIGATOR

Fuwai Hospital, National Center for Cardiovascular Disease

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Xiongjing Jiang, MD

Role: CONTACT

+861088322385

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Xiongjing Jiang, MD

Role: primary

86-1088322385

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2019-ZX09

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

FS VH S/D 500 S-apr in Vascular Surgery
NCT00892957 COMPLETED PHASE3