Evaluation of Microcirculatory Function and Mitochondrial Respiration After Cardiovascular Surgery

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

142 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-01

Study Completion Date

2023-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will examine the differences in microcirculatory function and mitochondrial respiration in patients with shock after cardiovascular surgery.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

CTO-PCI in Heart Failure Patients

NCT05632653

Coronary Artery Disease Chronic Total Occlusion Heart Failure

NOT_YET_RECRUITING NA

Ultrastructural Characteristics of Mitochondria in Cardiomyocytes in Heart Failure

NCT05770349

Heart Failure Coronary Artery Disease

RECRUITING

Myocardial Infarction in the Perioperative Setting

NCT03837535

Myocardial Infarction Postoperative Myocardial Injury Intraoperative Complications +2 more

COMPLETED

Acute Cardiac Dysfunction in Critical Illnes

NCT05860504

Multi Organ Failure Left Ventricular Dysfunction Right Ventricular Dysfunction +3 more

RECRUITING

Bilateral Surgical Resection of Carotid Bodies in Patients With Systolic Heart Failure

NCT01782677

Systolic Heart Failure Peripheral Chemoreceptor Hypersensitivity

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Post-cardiotomy shock (PCS) occurs in up to 5% of cardiovascular surgeries and has an in-hospital mortality rate as high as 75%. It is unclear if patients with PCS despite achieving standard resuscitation goals have impairments in oxygen delivery or oxygen utilization. This study will examine the difference in microcirculatory function and mitochondrial respiration in patients with shock to better understand the driving mechanism of bioenergetic failure in patients with PCS.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Shock Cardiovascular Diseases Critical Illness

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

No shock

Patients who have no evidence of clinical malperfusion or require vasoactive agents after cardiac surgery.

coronary artery bypass grafting, valve repair/replacement

Intervention Type PROCEDURE

cardiovascular surgery with cardiopulmonary bypass

Shock

Patients who have evidence of clinical malperfusion or require vasoactive agents after cardiac surgery.

coronary artery bypass grafting, valve repair/replacement

Intervention Type PROCEDURE

cardiovascular surgery with cardiopulmonary bypass

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

coronary artery bypass grafting, valve repair/replacement

cardiovascular surgery with cardiopulmonary bypass

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adult patients (\>18 years old)
* Receiving elective coronary artery bypass graft (CABG)
* Receiving valvular surgery requiring cardiopulmonary bypass

Exclusion Criteria

* Unable to tolerate sublingual microcirculatory flow imaging (e.g., non-intubated patients dependent upon oxygen by facemask, poor mouth opening)
* receiving an emergent procedure
* have an actively treated malignancy
* mitochondrial disorder
* receiving surgery requiring deep hypothermic circulatory arrest.

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No