A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF)

NCT ID: NCT05321069

Last Updated: 2025-10-20

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1177 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-06

Study Completion Date

2024-12-17

Brief Summary

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This study is open to adults with a lung disease called Idiopathic Pulmonary Fibrosis (IPF). People can join the study if they are 40 years or older. If they already take nintedanib or pirfenidone for their IPF, they can continue treatment throughout the study. The purpose of this study is to find out whether a medicine called BI 1015550 helps people with IPF.

Participants are put into 3 groups randomly, which means by chance. Participants in 2 groups take different doses of BI 1015550 as tablets twice a day. Participants in the placebo group take placebo tablets twice a day. Placebo tablets look like BI 1015550 tablets but do not contain any medicine.

Participants are in the study for up to two and a half years. During the first year, they visit the study site 10 times. Afterwards, they visit the study site every 3 months. The doctors regularly test participants' lung function. The results of the lung function tests are compared between the groups. The doctors also regularly check participants' health and take note of any unwanted effects.

Detailed Description

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Conditions

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Idiopathic Pulmonary Fibrosis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Nerandomilast 9 mg BID

Participants received 9 mg film-coated nerandomilast tablets orally twice daily, with doses administered at least 12 hours apart, each taken with 250 mL of water.

Group Type EXPERIMENTAL

BI 1015550

Intervention Type DRUG

Participants received film-coated nerandomilast tablets orally twice daily at doses of either 9 mg or 18 mg, with each dose administered at least 12 hours apart and taken with 250 mL of water.

Nerandomilast 18 mg BID

Participants received 18 mg film-coated nerandomilast tablets orally twice daily, with doses administered at least 12 hours apart, each taken with 250 mL of water.

Group Type EXPERIMENTAL

BI 1015550

Intervention Type DRUG

Participants received film-coated nerandomilast tablets orally twice daily at doses of either 9 mg or 18 mg, with each dose administered at least 12 hours apart and taken with 250 mL of water.

Placebo

Participants received placebo matching 9 mg or 18 mg nerandomilast film-coated tablets orally twice daily, with doses given at least 12 hours apart and each taken with 250 mL of water.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Participants received placebo matching 9 mg or 18 mg nerandomilast film-coated tablets orally twice daily, with doses given at least 12 hours apart and each taken with 250 mL of water.

Interventions

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BI 1015550

Participants received film-coated nerandomilast tablets orally twice daily at doses of either 9 mg or 18 mg, with each dose administered at least 12 hours apart and taken with 250 mL of water.

Intervention Type DRUG

Placebo

Participants received placebo matching 9 mg or 18 mg nerandomilast film-coated tablets orally twice daily, with doses given at least 12 hours apart and each taken with 250 mL of water.

Intervention Type DRUG

Other Intervention Names

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Nerandomilast, JASCAYD®

Eligibility Criteria

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Inclusion Criteria

1. Patients ≥40 years old at the time of signed informed consent.
2. Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial.
3. Diagnosis of Idiopathic Pulmonary Fibrosis (IPF).
4. Patients may be either:

* on a stable therapy\* with nintedanib or pirfenidone for at least 12 weeks prior to Visit 1 and during screening and are planning to stay on this background treatment after randomization. Combination of nintedanib plus pirfenidone is not allowed. (\*stable therapy is defined as the individually and general tolerated regimen of either nintedanib or pirfenidone (no dose changes) for at least 12 weeks).
* not on a treatment with nintedanib or pirfenidone for at least 8 weeks prior to Visit 1 and during the screening period (e.g. either Antifibrotic (AF)-treatment naïve or previously discontinued) and do not plan to start or re-start antifibrotic treatment.
5. Forced Vital Capacity (FVC) ≥45% of predicted normal at Visit 1.
6. Diffusing Capacity (of Lung) for Carbon Monoxide (DLCO) ≥25% of predicted normal corrected for hemoglobin (Hb) at Visit 1.
7. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control. WOCBP taking oral contraceptives (OCs) also have to use one barrier method.

Exclusion Criteria

1. Prebronchodilator Forced Expiratory Volume in 1 second (FEV1)/Forced vital capacity (FVC) \<0.7 at Visit 1.
2. In the opinion of the Investigator, other clinically significant pulmonary abnormalities.
3. Acute Idiopathic Pulmonary Fibrosis (IPF) exacerbation within 3 months prior to Visit 1 and/or during the screening period (investigator-determined).
4. Relevant chronic or acute infections including human immunodeficiency virus (HIV) and viral hepatitis.
5. Confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not fully recovered according to investigator judgement within the 4 weeks prior to randomization (Visit 2).
6. Major surgery (major according to the investigator's assessment) performed within 6 weeks prior to Visit 2 or planned during the trial period, e.g. hip replacement. Registration on lung transplantation list would not be considered as planned major surgery.
7. Any documented active or suspected malignancy or history of malignancy within 5 years prior to Visit 1, except appropriately treated basal cell carcinoma of the skin, in situ squamous cell carcinoma of the skin or in situ carcinoma of uterine cervix.
8. Aspartate aminotransferase (AST) or Alanine Aminotransferase (ALT) \>2.5 x Upper limit of normal (ULN) or total Bilirubin \>1.5 x ULN at Visit 1.
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boehringer Ingelheim

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

University of Southern California

Los Angeles, California, United States

Site Status

Cedars-Sinai Medical Center

Los Angeles, California, United States

Site Status

University of California Los Angeles

Los Angeles, California, United States

Site Status

University of California Davis

Sacramento, California, United States

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National Jewish Health

Denver, Colorado, United States

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Yale University School of Medicine

New Haven, Connecticut, United States

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Christiana Hospital

Newark, Delaware, United States

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Georgetown University

Washington D.C., District of Columbia, United States

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St. Francis Medical Institute

Clearwater, Florida, United States

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University of Florida Health Shands Hospital

Gainesville, Florida, United States

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Clinical Research Specialists LLC

Kissimmee, Florida, United States

Site Status

Advanced Pulmonary Research Institute

Loxahatchee Groves, Florida, United States

Site Status

Destin Pulmonary Critical Care

Santa Rosa Beach, Florida, United States

Site Status

Piedmont Healthcare-Atlanta-57055

Atlanta, Georgia, United States

Site Status

Evanston Hospital Pulmonary Clinic

Evanston, Illinois, United States

Site Status

University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Louisville Pulmonary Care

Louisville, Kentucky, United States

Site Status

Tulane University Hospital and Clinic

New Orleans, Louisiana, United States

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Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Brigham and Women's Hospital

Boston, Massachusetts, United States

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St. Elizabeth's Medical Center

Boston, Massachusetts, United States

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Infinity Medical Research

North Dartmouth, Massachusetts, United States

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University of Michigan Health System

Ann Arbor, Michigan, United States

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Beaumont Health

Royal Oak, Michigan, United States

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Minnesota Lung Center and Sleep Institute

Edina, Minnesota, United States

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University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic, Rochester

Rochester, Minnesota, United States

Site Status

The Lung Research Center, LLC

Chesterfield, Missouri, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

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Creighton University

Omaha, Nebraska, United States

Site Status

University of Nebraska Medical Center

Omaha, Nebraska, United States

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Renown Regional Medical Center

Reno, Nevada, United States

Site Status

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

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Northern Westchester Hospital

Mount Kisco, New York, United States

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Columbia University Medical Center-New York Presbyterian Hospital

New York, New York, United States

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Weill Cornell Medicine-New York-59955

New York, New York, United States

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Duke University Medical Center

Durham, North Carolina, United States

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Southeastern Research Center-Winston-Salem-61365

Winston-Salem, North Carolina, United States

Site Status

University of Cincinnati

Cincinnati, Ohio, United States

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Cleveland Clinic

Cleveland, Ohio, United States

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The Ohio State University Wexner Medical Center

Columbus, Ohio, United States

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The Oregon Clinic

Portland, Oregon, United States

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University of Pennsylvania

Philadelphia, Pennsylvania, United States

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Jefferson Health Honickman Center

Philadelphia, Pennsylvania, United States

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Temple University Hospital

Philadelphia, Pennsylvania, United States

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Allegheny General Hospital

Pittsburgh, Pennsylvania, United States

Site Status

Lowcountry Lung and Critical Care

Charleston, South Carolina, United States

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Clinical Trials Center of Middle Tennessee, LLC

Franklin, Tennessee, United States

Site Status

Vanderbilt University Medical Center - Vanderbilt Lung Institute at 100 Oaks

Nashville, Tennessee, United States

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Premier Pulmonary Critical Care and Sleep Medicine

Denison, Texas, United States

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The University of Texas Health Science Center at Houston

Houston, Texas, United States

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UT Health San Antonio

San Antonio, Texas, United States

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University of Utah Health Sciences Center

Salt Lake City, Utah, United States

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Virginia Mason Medical Center

Seattle, Washington, United States

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University of Wisconsin

Madison, Wisconsin, United States

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Centro de Investigaciones Metabolicas (CINME)-C.A.B.A-61553

C.a.b.a, , Argentina

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CEDIC - Centro de Investigacion Clinica

CABA, , Argentina

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Hospital Italiano de Buenos Aires

CABA, , Argentina

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Consultorios Médicos del Buen Ayre

Capital Federal, , Argentina

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Instituto Ave Pulmo

Mar del Plata, , Argentina

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INSARES

Mendoza, , Argentina

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Centro Respiratorio de Quilmes

Quilmes, , Argentina

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Canberra Hospital

Canberra, Australian Capital Territory, Australia

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Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia

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Westmead Hospital

Westmead, New South Wales, Australia

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Lung Research Queensland

Chermside, Queensland, Australia

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The Prince Charles Hospital

Chermside, Queensland, Australia

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Mater Hospital Brisbane

South Brisbane, Queensland, Australia

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Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

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Lung Research Victoria

Footscray, Victoria, Australia

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Austin Hospital

Heidelberg, Victoria, Australia

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The Alfred Hospital

Melbourne, Victoria, Australia

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Fiona Stanley Hospital

Murdoch, Western Australia, Australia

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Trialswest

Spearwood, Western Australia, Australia

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LKH Klagenfurt am Woerthersee

Klagenfurt, , Austria

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Krems University Hospital

Krems, , Austria

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Hospital Elisabethinen Linz

Linz, , Austria

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LKH Salzburg University Hospital

Salzburg, , Austria

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AKH - Medical University of Vienna

Vienna, , Austria

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Clinic Floridsdorf

Vienna, , Austria

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Klinikum Wels - Grieskirchen GmbH

Wels, , Austria

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Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim

Antwerp, , Belgium

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ULB Hopital Erasme

Brussels, , Belgium

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Cliniques Universitaires Saint-Luc

Brussels, , Belgium

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UNIV UZ Gent

Ghent, , Belgium

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UZ Leuven

Leuven, , Belgium

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Centre Hospitalier Universitaire de Liège

Liège, , Belgium

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Yvoir - UNIV UCL de Mont-Godinne

Yvoir, , Belgium

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Serviços Medicos Respirar Sul Fluminense

Barra Mansa, , Brazil

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Hospital das Clinicas da Universidade Federal de Minas Gerais (HCUFMG)

Belo Horizonte,Minas Gerais, , Brazil

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Edumed - Educacao e Saude SA

Curitiba, , Brazil

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CLARE - Clinica de Pneumologia

Goiânia, , Brazil

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Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre, , Brazil

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Instituto D´Or de Pesquisa e Ensino - Bahia

Salvador, , Brazil

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CEMEC - Centro Multidisciplinar de Estudos Clínicos

São Bernardo do Campo, , Brazil

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Hospital Alemao Oswaldo Cruz

São Paulo, , Brazil

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University of Alberta Hospital (University of Alberta)

Edmonton, Alberta, Canada

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Kelowna Respirology & Allergy Research

Kelowna, British Columbia, Canada

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Vancouver General Hospital

Vancouver, British Columbia, Canada

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St. Paul's Hospital (Vancouver)

Vancouver, British Columbia, Canada

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Dr. Georges-L.-Dumont University Hospital Centre

Moncton, New Brunswick, Canada

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QEII Health Sciences Centre

Halifax, Nova Scotia, Canada

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St. Joseph's Healthcare Hamilton

Hamilton, Ontario, Canada

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Dr. Syed Anees Medicine Professional Corporation

Windsor, Ontario, Canada

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Centre Hospitalier de l'Universite de Montreal (CHUM)

Montreal, Quebec, Canada

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McGill University Health Centre (MUHC)

Montreal, Quebec, Canada

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CIC Mauricie Inc.

Trois-Rivières, Quebec, Canada

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IUCPQ (Laval University)

Québec, , Canada

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Instituto Nacional del Tórax

Providencia, Santiago de Chile, , Chile

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Centro de Investigación del Maule

Talca, , Chile

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China-Japan Friendship Hospital

Beijing, , China

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Peking Union Medical College Hospital

Beijing, , China

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Chinese PLA General Hospital

Beijing, , China

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The Second Xiangya Hospital Of Central South University

Changsha, , China

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West China Hospital of Sichuan University

Chengdu, , China

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First Affiliated Hospital of Guangzhou Medical University

Guangzhou, , China

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NanFang Hosptial

Guangzhou, , China

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Hangzhou First People's Hospital

Hangzhou, , China

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The Second Affiliated Hospital Zhejiang University School of Medicine

Hangzhou, , China

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Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine

Hangzhou, , China

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Anhui Provincial Hospital

Hefei, , China

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The First hospital of Jiaxing

Jiaxing, , China

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Jinhua Municipal Central Hospital

Jinhua, , China

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Nanjing Drum Tower Hospital

Nanjing, , China

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The First Affiliated Hospital of Ningbo University

Ningbo, , China

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Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, , China

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Shanghai Chest Hospital

Shanghai, , China

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Zhongshan Hospital Affiliated to Fudan University

Shanghai, , China

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Huadong Hospital affiliated to Fudan University

Shanghai, , China

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Shanghai Pulmonary Hospital

Shanghai, , China

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China Shenyang Chest Hospital

Shenyang, , China

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Shenzhen People's Hospital

Shenzhen, , China

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The University of Hong Kong-Shenzhen Hospital

Shenzhen, , China

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People's Hospital of Sichuan Province

Sichuan, , China

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The First Affiliated Hospital of Soochow University

Suzhou, , China

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Tianjin Medical University General Hospital

Tianjin, , China

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Wuhan Union Hospital

Wuhan, , China

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Tongji Hospital Affiliated Tongji Medical College Huazhong University of S & T

Wuhan, , China

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Renmin Hospital of Wuhan University

Wuhan, , China

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Wuxi People's Hospital

Wuxi, , China

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Second Affiliated Hospital of Xi'an JiaoTong University

Xi'an, , China

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Affiliated Hospital, Xuzhou Medical college

Xuzhou, , China

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Yichang Central People's Hospital

Yichang, , China

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University Hospital Dubrava

Zagreb, , Croatia

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Aarhus University Hospital

Aarhus N, , Denmark

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Herlev and Gentofte Hospital

Hellerup, , Denmark

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Odense University Hospital

Odense, , Denmark

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North Estonia Medical Centre Foundation, Tallinn

Tallinn, , Estonia

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HYKS Keuhkosairauksien tutkimusyksikkö

Helsinki, , Finland

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Oulun yliopistollinen keskussairaala

Oulu, , Finland

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HOP d'Angers

Angers, , France

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HOP Avicenne

Bobigny, , France

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HOP de la Cavale Blanche

Brest, , France

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HOP Louis Pradel

Bron, , France

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HOP CHU Caen

Caen, , France

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HOP François Mitterrand

Dijon, , France

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HOP Michallon

La Tronche, , France

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HOP Bicêtre

Le Kremlin-Bicêtre, , France

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INS Coeur Poumon

Lille, , France

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HOP Nord

Marseille, , France

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HOP Nord Laennec

Nantes, , France

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HOP Pasteur

Nice, , France

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HOP Paris Saint-Joseph

Paris, , France

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HOP Tenon

Paris, , France

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HOP Bichat

Paris, , France

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HOP Haut-Lévêque

Pessac, , France

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HOP Robert Debré

Reims, , France

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HOP Pontchaillou

Rennes, , France

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HOP Charles Nicolle

Rouen, , France

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HOP Civil

Strasbourg, , France

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HOP Foch

Suresnes, , France

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HOP Larrey

Toulouse, , France

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HOP Bretonneau

Tours, , France

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Velocity Clinical Research Germany GmbH, Ahrensburg

Ahrensburg, , Germany

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CIMS Studienzentrum Bamberg GmbH

Bamberg, , Germany

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Vivantes Netzwerk für Gesundheit GmbH

Berlin, , Germany

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Universitätsklinikum Bonn AöR

Bonn, , Germany

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Klinikum Chemnitz gGmbH

Chemnitz, , Germany

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Fachkrankenhaus Coswig GmbH

Coswig, , Germany

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Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen gGmbH

Essen, , Germany

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Universitätsklinikum Hamburg, Eppendorf

Hamburg, , Germany

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Klinikum Region Hannover GmbH

Hanover, , Germany

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Medizinische Hochschule Hannover

Hanover, , Germany

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Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg

Heidelberg, , Germany

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Lungenklinik Hemer

Hemer, , Germany

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Lungenfachklinik Immenhausen

Immenhausen, , Germany

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Klinikum Konstanz

Konstanz, , Germany

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Klinikum der Universität München - Campus Großhadern

München, , Germany

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Klinikum Nürnberg

Nuremberg, , Germany

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Krankenhaus Bethanien gGmbH

Solingen, , Germany

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Helios Hanseklinikum Stralsund

Stralsund, , Germany

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Robert-Bosch-Krankenhaus GmbH

Stuttgart, , Germany

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Universitätsklinikum Tübingen

Tübingen, , Germany

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Petrus-Krankenhaus

Wuppertal, , Germany

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Hospital of Heraklion (PAGNI)

Crete, , Greece

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Univ. Gen. Hosp. of Ioannina

Ioannina, , Greece

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Univ. Gen. Hosp. of Patras

Pátrai, , Greece

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Koranyi National Institute For Pulmonolgy

Budapest, , Hungary

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University of Debrecen Clinical Centre

Debrecen, , Hungary

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Connolly Hospital Blanchardstown

Dublin, , Ireland

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A.O.U. Policlinico Vittorio Emanuele

Catania, , Italy

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A. O. Universitaria Careggi

Florence, , Italy

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Ospedale Colonnello D Avanzo

Foggia, , Italy

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Ospedale G.B. Morgagni

Forlì, , Italy

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Ospedale Classificato San Giuseppe

Milan, , Italy

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Azienda Ospedaliera Policlinico di Modena

Modena, , Italy

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Azienda Ospedaliera Universitaria di Padova

Padua, , Italy

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Pol. Universitario Tor Vergata

Roma, , Italy

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Fondazione Policlinico Universitario A. Gemelli IRCCS

Roma, , Italy

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A.O.U. Senese

Siena, , Italy

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Ospedali Riuniti di Ancona

Torrette Di Ancona (Ancona), , Italy

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Tosei General Hospital

Aichi, Seto, , Japan

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Fujita Health University Hospital

Aichi, Toyoake, , Japan

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Chiba University Hospital

Chiba, Chiba, , Japan

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IUHW Narita Hospital

Chiba, Narita, , Japan

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University of Fukui Hospital

Fukui, Yoshida-gun, , Japan

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National Hospital Organization Kyushu Medical Center

Fukuoka, Fukuoka, , Japan

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Kyushu University Hospital

Fukuoka, Fukuoka, , Japan

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Aso Co.,Ltd Iizuka Hospital

Fukuoka, Iizuka, , Japan

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Kurume University Hospital

Fukuoka, Kurume, , Japan

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Fukushima Medical University Hospital

Fukushima, Fukushima, , Japan

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Tsuboi Hospital

Fukushima, Koriyama, , Japan

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Hiroshima Prefectural Hospital

Hiroshima, Hiroshima, , Japan

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Sapporo Medical University Hospital

Hokkaido, Sapporo, , Japan

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National Hospital Organization Himeji Medical Center

Hyogo, Himeji, , Japan

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Kobe City Medical Center General Hospital

Hyogo, Kobe, , Japan

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Kobe City Hospital Organization Kobe City Medical Center West Hospital

Hyogo, Kobe, , Japan

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Kanagawa Cardiovascular and Respiratory Center

Kanagawa, Yokohama, , Japan

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Saiseikai Kumamoto Hospital

Kumamoto, Kumamoto, , Japan

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Nagasaki University Hospital

Nagasaki, Nagasaki, , Japan

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Kindai University Hospital

Osaka, Osakasayama, , Japan

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National Hospital Organization Kinki-Chuo Chest Medical Center

Osaka, Sakai, , Japan

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Saitama Red Cross Hospital

Saitama, Saitama, , Japan

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Shimane University Hospital

Shimane, Izumo, , Japan

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Hamamatsu University Hospital

Shizuoka, Hamamatsu, , Japan

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Jichi Medical University Hospital

Tochigi, Shimotsuke, , Japan

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Tokushima University Hospital

Tokushima, Tokushima, , Japan

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Juntendo University Hospital

Tokyo, Bunkyo-ku, , Japan

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Toranomon Hospital

Tokyo, Minato-ku, , Japan

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Kyorin University Hospital

Tokyo, Mitaka, , Japan

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Toho University Omori Medical Center

Tokyo, Ota-ku, , Japan

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Tokyo Medical University Hospital

Tokyo, Shinjuku-ku, , Japan

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National Center for Global Health and Medicine

Tokyo, Shinjuku-ku, , Japan

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Wakayama Medical University Hospital

Wakayama, Wakayama, , Japan

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Hospital Sultan Idris Shah Serdang

Kajang, , Malaysia

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Institut Perubatan Respiratori

Kuala Lumpur, , Malaysia

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Sarawak General Hospital

Kuching, , Malaysia

Site Status

Hospital Pulau Pinang-Pulau Pinang-21953

Pulau Pinang, , Malaysia

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Centro de Investigacion Integral MEDIVEST S.C

Chihuahua City, , Mexico

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Soltmed Smo

Mexico City, , Mexico

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Centro Respiratorio de Mexico

Mexico City, , Mexico

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Centro de Prevención y Rehabilitación de Enfermedades Pulmon

Monterrey, , Mexico

Site Status

Oaxaca Site Management Organization, S.C.

Oaxaca City, , Mexico

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Zuyderland Medisch Centrum

Heerlen, , Netherlands

Site Status

St. Antonius ziekenhuis, locatie Nieuwegein

Nieuwegein, , Netherlands

Site Status

Erasmus Medisch Centrum-ROTTERDAM-50697

Rotterdam, , Netherlands

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Waikato Hospital

Hamilton, , New Zealand

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Greenlane Clinical Centre

One Tree Hill, Auckland, , New Zealand

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Middlemore Clinical Trials

Papatoetoe, , New Zealand

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Tauranga Hospital

Tauranga South, , New Zealand

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Haukeland Universitetssykehus

Bergen, , Norway

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Akershus Universitetssykehus HF

Lørenskog, , Norway

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Oslo Universitetssykehus HF, Rikshospitalet

Oslo, , Norway

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University Clinical Center, Gdansk

Gdansk, , Poland

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Alergopneuma Medical Center

Świdnik, , Poland

Site Status

Nat.Instit.of Tuberculosis&LungDiseases,Outpat.Clin,warszawa

Warsaw, , Poland

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ULS de Coimbra, E.P.E.

Coimbra, , Portugal

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USLM, EPE - Hospital Pedro Hispano

Matosinhos Municipality, , Portugal

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Allianze Pulmonary Research LLC

Guaynabo, , Puerto Rico

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National University Hospital-Singapore-42005

Singapore, , Singapore

Site Status

Singapore General Hospital

Singapore, , Singapore

Site Status

Tan Tock Seng Hospital

Singapore, , Singapore

Site Status

Busamed Paardevlei Private Hospital

Cape Town, , South Africa

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Melomed Gatesville Hospital

Cape Town, , South Africa

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KwaPhila Health Solutions

Durban, , South Africa

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The Catholic University of Korea, Bucheon St.Mary's Hospital

Bucheon-si, , South Korea

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Seoul National University Bundang Hospital

Seongnam, , South Korea

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Kyung Hee University Hospital

Seoul, , South Korea

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Seoul National University Hospital

Seoul, , South Korea

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Severance Hospital

Seoul, , South Korea

Site Status

Soonchunhyang University Hospital Seoul

Seoul, , South Korea

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Asan Medical Center

Seoul, , South Korea

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Samsung Medical Center

Seoul, , South Korea

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Hospital General Universitario de Alicante

Alicante, , Spain

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Hospital del Mar

Barcelona, , Spain

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Hospital Universitari Vall D Hebron

Barcelona, , Spain

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Hospital Clínic de Barcelona

Barcelona, , Spain

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Hospital de Basurto

Bilbao, , Spain

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Hospital Universitario Virgen de la Arrixaca

El Palmar, , Spain

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Hospital de Galdakao

Galdakao, , Spain

Site Status

Hospital Universitari de Girona Doctor Josep Trueta

Girona, , Spain

Site Status

Hospital Universitario Virgen de las Nieves

Granada, , Spain

Site Status

Hospital de Bellvitge

L'Hospitalet de Llobregat, , Spain

Site Status

Hospital Universitario Lucus Augusti

Lugo, , Spain

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Hospital La Princesa

Madrid, , Spain

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Hospital General Universitario Gregorio Marañón

Madrid, , Spain

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Hospital Universitario Infanta Leonor

Madrid, , Spain

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Hospital Universitario Ramon Y Cajal

Madrid, , Spain

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Hospital Universitario 12 de Octubre

Madrid, , Spain

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Hospital Virgen de la Victoria

Málaga, , Spain

Site Status

Hospital Central de Asturias

Oviedo, , Spain

Site Status

Hospital Son Espases

Palma de Mallorca, , Spain

Site Status

Hospital Quirónsalud Madrid

Pozuelo de Alarcón, , Spain

Site Status

Hospital Universitario Marqués de Valdecilla

Santander, , Spain

Site Status

Hospital Clínico de Santiago

Santiago de Compostela, , Spain

Site Status

Hospital Virgen del Rocío

Seville, , Spain

Site Status

Hospital Nuestra Señora de Valme

Seville, , Spain

Site Status

Hospital General Universitario de Valencia

Valencia, , Spain

Site Status

Universitetssjukhuset, Linköping

Linköping, , Sweden

Site Status

Sahlgrenska Universitetsjukhuset

Stockholm, , Sweden

Site Status

Akademiska sjukhuset

Uppsala, , Sweden

Site Status

Universitätsspital Basel

Basel, , Switzerland

Site Status

Chang-Hua Christian Hospital

Changhua, , Taiwan

Site Status

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, , Taiwan

Site Status

Taichung Veterans General Hospital

Taichung, , Taiwan

Site Status

NCKUH

Tainan City, , Taiwan

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status

Siriraj Hospital

Bangkok Noi, , Thailand

Site Status

Songklanagarind Hospital

Hat Yai, , Thailand

Site Status

Srinagarind Hospital

Khon Kaen, , Thailand

Site Status

Central Chest Institute of Thailand

Muang, , Thailand

Site Status

Maharat Nakhonchiangmai Hospital

Muang, , Thailand

Site Status

Ramathibodi Hospital

Ratchatewi, , Thailand

Site Status

Queen Elizabeth Hospital Birmingham

Birmingham, , United Kingdom

Site Status

Southmead Hospital

Bristol, , United Kingdom

Site Status

Royal Infirmary of Edinburgh

Edinburgh, , United Kingdom

Site Status

Royal Devon and Exeter Hospital, Wonford

Exeter, , United Kingdom

Site Status

Royal Lancaster Infirmary

Lancaster, , United Kingdom

Site Status

St James's University Hospital

Leeds, , United Kingdom

Site Status

Royal Brompton Hospital

London, , United Kingdom

Site Status

Wythenshawe Hospital

Manchester, , United Kingdom

Site Status

Churchill Hospital

Oxford, , United Kingdom

Site Status

Countries

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United States Argentina Australia Austria Belgium Brazil Canada Chile China Croatia Denmark Estonia Finland France Germany Greece Hungary Ireland Italy Japan Malaysia Mexico Netherlands New Zealand Norway Poland Portugal Puerto Rico Singapore South Africa South Korea Spain Sweden Switzerland Taiwan Thailand United Kingdom

References

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Richeldi L, Azuma A, Cottin V, Kreuter M, Maher TM, Martinez FJ, Oldham JM, Valenzuela C, Clerisme-Beaty E, Gordat M, Wachtlin D, Liu Y, Schlecker C, Stowasser S, Zoz DF, Wijsenbeek MS; FIBRONEER-IPF Trial Investigators. Nerandomilast in Patients with Idiopathic Pulmonary Fibrosis. N Engl J Med. 2025 Jun 12;392(22):2193-2202. doi: 10.1056/NEJMoa2414108. Epub 2025 May 18.

Reference Type DERIVED
PMID: 40387033 (View on PubMed)

Richeldi L, Azuma A, Cottin V, Kreuter M, Maher TM, Martinez FJ, Oldham JM, Valenzuela C, Gordat M, Liu Y, Stowasser S, Zoz DF, Wijsenbeek MS. Design of a phase III, double-blind, randomised, placebo-controlled trial of BI 1015550 in patients with idiopathic pulmonary fibrosis (FIBRONEER-IPF). BMJ Open Respir Res. 2023 Aug;10(1):e001563. doi: 10.1136/bmjresp-2022-001563.

Reference Type DERIVED
PMID: 37597969 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Related Links

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Other Identifiers

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2022-001091-34

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

1305-0014

Identifier Type: -

Identifier Source: org_study_id

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