Transversus Abdominis Plane Block Versus Quadratus Lumborum Block for Pain Management in Laparoscopic Appendectomy

NCT ID: NCT05310266

Last Updated: 2022-07-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

168 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-04-06

Study Completion Date

2022-02-21

Brief Summary

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Laparoscopic appendectomy causes postoperative pain. The primary objective of this prospective randomized controlled study is to compare the effect of ultrasound (US)-guided quadratus lumborum block (QLB) on 24-hour cumulative opioid requirements with transversus abdominis plane (TAP) block.

Detailed Description

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168 patients (ASA I-II-III) between 18 and 65 years of age, who were to undergo laparoscopic appendectomy, were randomized and divided into two groups. 32 patients were dropout for different reasons.(68 patients in each of the TAP block and QLB block groups). TAP block was performed for TAP group and QLB block was performed for QLB group. Postoperative analgesia was provided by intravenous tramadol hydrochloride using a patient-controlled analgesia device. 24-hour total tramadol hydrochloride consumption was primary outcome measure.Postoperative numeric rating scale values were the secondary outcome measure.

Conditions

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Post Operative Pain Appendicitis Acute Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Group TAP

The investigators performed transversus abdominis plane block to that patient group for postoperative analgesia

Group Type ACTIVE_COMPARATOR

Transversus abdominis plane block

Intervention Type PROCEDURE

The investigators performed transversus abdominis plane block to that patient group for postoperative analgesia

Group QLB

The investigators performed quadratus lumborum block to that patient group for postoperative analgesia

Group Type ACTIVE_COMPARATOR

Quadratus Lumborum Block

Intervention Type PROCEDURE

The investigators performed quadratus lumborum block to that patient group for postoperative analgesia

Interventions

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Transversus abdominis plane block

The investigators performed transversus abdominis plane block to that patient group for postoperative analgesia

Intervention Type PROCEDURE

Quadratus Lumborum Block

The investigators performed quadratus lumborum block to that patient group for postoperative analgesia

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Ages of 18-65
* Patients who will undergo laparoscopic appendectomy
* ASA I-II-III patients

Exclusion Criteria

* Clinically known local anesthetic allergy
* Morbid obesity (body mass index\>40 kg m2)
* Clinically diagnosis of opioid, alcohol and substance dependence
* Clinically diagnosis of psychiatric disease
* Coagulopathy
* Patients with ASA IV-V
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bakirkoy Dr. Sadi Konuk Research and Training Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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Gokhan Sertcakacilar, MD

Principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Istanbul, Bakirkoy, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Tupper-Carey DA, Fathil SM, Tan YK, Kan YM, Cheong CY, Siddiqui FJ, Assam PN. A randomised controlled trial investigating the analgesic efficacy of transversus abdominis plane block for adult laparoscopic appendicectomy. Singapore Med J. 2017 Aug;58(8):481-487. doi: 10.11622/smedj.2016068. Epub 2016 Apr 8.

Reference Type RESULT
PMID: 27056207 (View on PubMed)

Baytar C, Yilmaz C, Karasu D, Topal S. Comparison of Ultrasound-Guided Subcostal Transversus Abdominis Plane Block and Quadratus Lumborum Block in Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Study. Pain Res Manag. 2019 Feb 3;2019:2815301. doi: 10.1155/2019/2815301. eCollection 2019.

Reference Type RESULT
PMID: 30863471 (View on PubMed)

Saleh AH, Abdallah MW, Mahrous AM, Ali NA. Quadratus lumborum block (transmuscular approach) versus transversus abdominis plane block (unilateral subcostal approach) for perioperative analgesia in patients undergoing open nephrectomy: a randomized, double-blinded, controlled trial. Braz J Anesthesiol. 2021 Jul-Aug;71(4):367-375. doi: 10.1016/j.bjane.2021.01.009. Epub 2021 Mar 21.

Reference Type RESULT
PMID: 33762197 (View on PubMed)

Other Identifiers

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2020-35

Identifier Type: -

Identifier Source: org_study_id

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