Investigating Myocardial Remodelling in the Failing Human Heart

NCT ID: NCT05303896

Last Updated: 2025-07-31

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-05-30
• Study Completion Date: 2030-07-31

Brief Summary

Despite improvements in therapy, heart failure is a disease with high mortality and accelerating prevalence. To improve patient care, it is necessary to better understand the features and underlying mechanisms of myocardial remodeling; how it manifests in vivo and its underlying cellular and extracellular changes. The RELAX study will offer insight into myocardial remodeling, by comprehensively assessing function and structure of failing human hearts, and investigate its underlying cellular and extracellular changes.

Conditions

Heart Failure

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Eligible for heart transplantation
• Willingness to participate in the present study and ability to understand and sign the written informed consent

Exclusion Criteria

• Patients under the age of 18.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Oslo University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Ivar Sjaastad

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ivar Sjaastad, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Oslo, Oslo University Hospital

Locations

Oslo University Hospital

Oslo, Oslo County, Norway

Site Status: RECRUITING

Countries

Norway

Central Contacts

Henrik Dukefoss, MD

Role: CONTACT

h.b.dukefoss@studmed.uio.no

95433188

Facility Contacts

Ivar Sjaastad, MD, PhD

Role: primary

ivar.sjaastad@medisin.uio.no

90792893

Other Identifiers

230524

Identifier Type: -

Identifier Source: org_study_id