Study of Application of Transcutaneous Trigeminal Nerve Stimulation and Sound Fusion Stimulation on Tinnitus

NCT ID: NCT05291078

Last Updated: 2023-09-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-22

Study Completion Date

2021-05-18

Brief Summary

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This study aims to evaluate the efficacy of applying transcutaneous trigeminal nerve stimulation (NUEYNE-T30, NUEYNE-T100) and sound fusion stimulation on tinnitus.

Detailed Description

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Duration of study period (per participant): Screening period (-7\~0 days), Intervention period (30 days) Patient needs to visit site at least 3 times (Screening, V1, V2). V1 can be done with screening visit. Tele-visit should be done on day 15.

Conditions

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Tinnitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Experimental Group A

Tinnitus patients(n=12 people)

Group Type EXPERIMENTAL

A transcutaneous trigeminal nerve stimulator: High Frequency

Intervention Type DEVICE

30min/day, at least 5 to 7 times a week

Sound Therapy

Intervention Type DEVICE

Notch Therapy at least 30min/day, at least 5 to 7 times a week

Experimental Group B

Tinnitus patients(n=12 people)

Group Type EXPERIMENTAL

A transcutaneous trigeminal nerve stimulator: Low Frequency

Intervention Type DEVICE

30min/day, at least 5 to 7 times a week

Sound Therapy

Intervention Type DEVICE

Notch Therapy at least 30min/day, at least 5 to 7 times a week

Control Group

Tinnitus patients(n=12 people)

Group Type SHAM_COMPARATOR

A transcutaneous trigeminal nerve stimulator: Sham

Intervention Type DEVICE

30min/day, at least 5 to 7 times a week

Sound Therapy

Intervention Type DEVICE

Notch Therapy at least 30min/day, at least 5 to 7 times a week

Interventions

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A transcutaneous trigeminal nerve stimulator: High Frequency

30min/day, at least 5 to 7 times a week

Intervention Type DEVICE

A transcutaneous trigeminal nerve stimulator: Low Frequency

30min/day, at least 5 to 7 times a week

Intervention Type DEVICE

A transcutaneous trigeminal nerve stimulator: Sham

30min/day, at least 5 to 7 times a week

Intervention Type DEVICE

Sound Therapy

Notch Therapy at least 30min/day, at least 5 to 7 times a week

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* adults suffering from tinnitus
* Participants must be 19 to 70 years of age, at the time of screening
* Patient who suffers from tinnitus symptom more than 3 months and scores more than 18(criteria of mild) in Tinnitus Handicap Inventory (THI) examination
* Patients with a hearing threshold of 70dB or less when calculated using the quadrant method in the pure tone audiometry
* A person who has no physical or mental restrictions in participating in clinical trial
* Those who voluntarily agreed to participate in clinical trials
* A person who has no pregnancy plan and has agreed to the contraceptive plan for infertile women during the intervention period of clinical trial

* A person who has difficulty communicating and conducting examinations.
* The disease of the outer or middle ear or central nervous system.
* Subjects who have difficulty conducting clinical trials due to intellectual or cognitive impairment
* Pregnant or lactating women
* A person who cannot understand or read ICF (illiterate or foreigner)
* A person who received tinnitus treatment (blood circulation enhancer, tranquilizer, tinnitus masker, biofeedback etc.) within 2 weeks of baseline or plans to receive it.
* A person who is difficult to participate in a clinical trial according to the researcher's judgment. (e.g., heart-related problems, seizure, epilepsy. Patients transplanted metal or electronic device in head \& neck. Patient suffering from unknown pain. Patients who are warned not to use out clinical trial device or is prohibited from using it.)
Minimum Eligible Age

19 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nu Eyne Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Iljoon Moon, Ph. D., MD.

Role: PRINCIPAL_INVESTIGATOR

Department of Otorhinolaryngology, Samsung Medical Center

Locations

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Department of Otorhinolaryngology, Samsung Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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NE_TNT_IIT001

Identifier Type: -

Identifier Source: org_study_id

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