Intraperitoneal Instillation of Levobupivacaine With Morphine Versus Levobupivacaine With Magnesium Sulfate for Postoperative Analgesia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-01

Study Completion Date

2021-12-01

Brief Summary

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This is a prospective randomized study that included 60 patients and was divided into two equal groups of patients who were scheduled for LC, Ages 18 and 60 years, both sexes, ASA I-II and BMI 19 - 39. Group A received 30 ml levobupivacaine (0.25%) plus 3 mg morphine intraperitoneal at the site of surgery in the bed of the gallbladder via the navel port with the patient in a Trendelenburg position, Group B received 30 ml levobupivacaine (0.25%) plus 50 mg/kg magnesium sulfate in the same pattern as in the A group.

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Detailed Description

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Conditions

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Post Operative Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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levobupivacaine with morphine

30 patients will have intraperitoneal instillation of levobupivacaine with added morphine at the end of laparoscopic cholecystectomy operation

Group Type ACTIVE_COMPARATOR

intraperitoneal levobupivacaine and morphine

Intervention Type DRUG

istillation of the peritoneum with levobupivacaine mixture with morphine

levobupivacaine with magnesium sulfate

30 patients will have intraperitoneal instillation of levobupivacaine with added magnesium sulfate at the end of laparoscopic cholecystectomy operation

Group Type EXPERIMENTAL

intraperitoneal levobupivacaine and morphine

Intervention Type DRUG

istillation of the peritoneum with levobupivacaine mixture with morphine

Interventions

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intraperitoneal levobupivacaine and morphine

istillation of the peritoneum with levobupivacaine mixture with morphine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who were scheduled for L.C,
* Ages 18 and 60 years
* ASA I-II and
* BMI 19 - 39

Exclusion Criteria

* Patients with hepatic or renal dysfunction
* use of opioids 24 hrs prior to the study
* treatment with steroids prior to surgery
* drug or alcohol abuse, allergy to any of the study drugs
* chronic pain syndrome as a result of neurological disease

Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No