Comparison Between Different Doses of Steroids in COVID-19 Patients

NCT ID: NCT05279482

Last Updated: 2022-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

104 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-19

Study Completion Date

2022-03-09

Brief Summary

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aim of this study is to compare between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate, percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

Detailed Description

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Retrospective study for comparison between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate ,percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

Previous studies suggested that cytokine release syndrome could be involved in the pathophysiology of critical SARS.COV.2 resulting in death so early suppression of cytokine storm may be lifesaving in critical patients.

Conditions

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Critical Illness Pneumonia, Viral

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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group treated with standard dose methyl prednisolone

patients with positive PCR and requiring oxygen therapy

observation for outcome of methylprednisolone dose

Intervention Type OTHER

no intervention as it is retrospective study for outcome

group treated with mega dose methyl prednisolone

patients with positive PCR and requiring oxygen therapy

observation for outcome of methylprednisolone dose

Intervention Type OTHER

no intervention as it is retrospective study for outcome

Interventions

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observation for outcome of methylprednisolone dose

no intervention as it is retrospective study for outcome

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All icu admitted covid 19 patients with positive PCR, diagnosed by CT chest and needing oxygen therapy

Exclusion Criteria

* Not requiring oxygen therapy
* Negative PCR
* Uncontrolled blood sugar or DKA
* Patients on long term steroids therapy
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ain Shams University

OTHER

Sponsor Role lead

Responsible Party

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Amr M Hilal Abdou

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ain shams university hospitals

Cairo, , Egypt

Site Status

Faculty of medicine, Ain Shams University

Cairo, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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MS41/2022

Identifier Type: -

Identifier Source: org_study_id

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