Cohort Study of Heart Failure With Preserved Ejection Fraction in Chinese Han

NCT ID: NCT05278026

Last Updated: 2022-03-14

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 2000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-01-01
• Study Completion Date: 2026-01-01

Brief Summary

To analyze factors contributing to the development and prognosis of heart failure with preserved ejection fraction.

Detailed Description

Based on previous studies on development of heart failure with preserved ejection fraction (HFpEF), racial/ethnical background should be underscored when evaluating risk f actors for HFpEF incidence. As the ageing population increases sharply in China, HFpEF represents the dominant phenotype of all patients diagnosed with heart failure. In this cohort study, the investigators evaluated exposures or risk factors for HFpEF in Chinese Han patients with cardiovascular diseases (CVD). Our study may provide preventive and therapeutic targets for HFpEF in Chinese CVD patients.

Conditions

Heart Failure

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

HFrEF

heart failure with reduced ejection fraction

guideline recommended routine treatment

Intervention Type: OTHER

HFpEF

heart failure with preserved ejection fraction

guideline recommended routine treatment

Intervention Type: OTHER

nonfailing control

patients without heart failure

guideline recommended routine treatment

Intervention Type: OTHER

Interventions

guideline recommended routine treatment

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patients with CVD, defined as at least one diagnosis of coronary heart disease, hypertension, type 2 diabetes or cardiomyopathy. The definition of coronary heart disease was stenosis of the main coronary arteries ≥ 50% using percutaneous coronary angiography or coronary computed tomography angiography findings. The definition of hypertension was systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg or pharmacological treatment. The definition of type 2 diabetes was fasting blood glucose ≥ 7.0 mmol/L, random blood glucose ≥ 11.1 mmol/L and HbA1c > 6.5% or the or the use of hypoglycaemic medications. Cardiomyopathy was defined as the presence of cardiac insufficiency in patients with dilated cardiomyopathy suggested by percutaneous coronary angiography or coronary CT angiography use of hypoglycaemic medications.

Exclusion Criteria

• primary diagnoses of atherosclerosis (stenosis of the main coronary arteries < 50%), congenital heart diseases, arrhythmia, lung diseases, aortic dissection, peripheral vascular diseases, pericardial diseases, myocarditis, hypertrophic cardiomyopathy, heart valvular diseases, cardiophobia, costal chondritis, shock, thyroid diseases, infection or concomitant liver or renal dysfunction.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Nanjing First Hospital, Nanjing Medical University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Nanjing First Hospital

Nanjing, Jiangsu, China

Site Status: RECRUITING

Countries

China

Central Contacts

Junxia Zhang, MD

Role: CONTACT

zhangjunshia@njmu.edu.cn

15366155682

Chunlei Xia, MD

Role: CONTACT

thunder0703@163.com

18796281113

Facility Contacts

俊霞 张, MD

Role: primary

zhangjunshia@njmu.edu.cn

15366155682

Related Links

https://pubmed.ncbi.nlm.nih.gov/30354212/

Lp(a) \[Lipoprotein(a)\]-Related Risk of Heart Failure Is Evident in Whites but Not in Other Racial/Ethnic Groups

https://pubmed.ncbi.nlm.nih.gov/28501527/

Race/Ethnic Differences in Outcomes Among Hospitalized Medicare Patients With Heart Failure and Preserved Ejection Fraction

https://pubmed.ncbi.nlm.nih.gov/29664406/

Racial Differences in Characteristics and Outcomes of Patients With Heart Failure and Preserved Ejection Fraction in the Treatment of Preserved Cardiac Function Heart Failure Trial

Other Identifiers

ChiHFpEF-Cohort

Identifier Type: -

Identifier Source: org_study_id