Plaque Stability and Metabolomics in Coronary Heart Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-01

Study Completion Date

2024-07-31

Brief Summary

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At present, the investigators don't know the relationship between plaque stability and the metabonomics changes. In the present study, investigators will evaluate the plaque stability by intravascular unltrasound in stable coronary heart patients, and metabonomics was also assessed by high throughput sequencing. Statistic analysis were carried out to analyze the correlation between plaque stability and metabonomics changes among these study patients.

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Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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This is an observational study, we don't have any interventions.

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients who diagnosed with stable coronary heart disease and evaluated for plaque stability by IVUS will be recruited.

Exclusion Criteria

* renal insufficiency with serum creatinine \> 20 mg/L;
* regnant/lactating women, or the women receive hormone replacement therapy in premenopausal or postmenopausal;
* patients have a history of abusing alcohol or other drugs in the past two years, active hepatitis, cirrhosis;
* endocrine abnormalities without therapy (diabetic ketoacidosis, thyroid disease, etc.);
* The body's inflammatory disease, rheumatoid arthritis, osteoarthritis, ulcerative bowel disease, systemic lupus erythematosus (sle), etc.), myositis/myopathy, cancer;
* Dilated cardiomyopathy, valvular heart disease, persistent atrial fibrillation;
* patients recently injured;（8）Other researchers don't agree to join this study.

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No