Efficacy of Cranial Manual Therapy in the Treatment of Chronic Insomnia Disorder
NCT ID: NCT05257317
Last Updated: 2022-02-25
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
UNKNOWN
Clinical Phase
NA
Total Enrollment
50 participants
Study Classification
INTERVENTIONAL
Study Start Date
2022-02-28
Study Completion Date
2023-09-30
Brief Summary
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Insomnia is the most prevalent sleep disorder in society. The first treatment of choice is pharmacology, although it can have secondary effects such as tolerance and dependence, or alter the structure of sleep; therefore, new pathways towards other adjuvant treatments are being established. OBJECTIVES: The main objective is "To assess the effectiveness of manual cranial therapy on the quantity and quality of sleep in patients with chronic insomnia." MATERIAL AND METHODS: A randomized clinical trial is designed, with two groups, intervention and placebo, to assess the effectiveness of manual therapy applied to the skull, in the severity of insomnia, and quantity and quality of sleep in patients with sleep disorder. chronic insomnia. Health professionals will be selected from the Department of Occupational Health, with characteristics of chronic insomnia described by the ICSD-III, who do not modify their usual medication regimen (if they take it) and without other pathologies related to sleep that may be causing the insomnia. insomnia Demographic data (age, sex, profession), clinical (BMI, history of previous and family insomnia pathologies, and taking medication for sleep and related disorders), sleep quality questionnaires (PSQI, COS, ISI) will be collected. , stress-insomnia relationship (FISRST-S), and quality of life (SF12), in addition to filling out a sleep diary (through the mobile App) and recording activity through actigraphy, hypnogram (Sleep ProfilerTM); before and after the intervention, and at one and three month follow-up. Each group will receive the offered intervention: cranial manual therapy (intervention) or cranial massage (placebo). The data will be coded and analyzed with the IBM SPSS® version 20 program (or similar)
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Detailed Description
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Conditions
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Sleep Initiation and Maintenance Disorders
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
SINGLE
Participants
Study Groups
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Intervention
It will consist of osteopathic manual therapy techniques applied to the occipital and temporal bones.
Group Type
EXPERIMENTAL
Osteopathic Medicine
Intervention Type
OTHER
Where compression and traction movements will be carried out on these structures.
Technique called CV4, applied on the occipital, and Technique called asynchronous rolling of the temporal bones.
Placebo
It consists of a light contact applied to the cranial vault (frontal and parietal bones) where circular movements will be induced.
Group Type
PLACEBO_COMPARATOR
Placebo therapy
Intervention Type
OTHER
Circular movements will be induced in a frontal and parietal bones
Interventions
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Osteopathic Medicine
Where compression and traction movements will be carried out on these structures.
Technique called CV4, applied on the occipital, and Technique called asynchronous rolling of the temporal bones.
Intervention Type
OTHER
Placebo therapy
Circular movements will be induced in a frontal and parietal bones
Intervention Type
OTHER
Eligibility Criteria
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Inclusion Criteria
* Diagnosed with chronic insomnia disorder according to the criteria defined by the ICSD-III (International Classification of Sleep Disorders-3rd edition):
* Problems initiating or maintaining sleep, associated with daytime consequences; and not attributable to environmental circumstances.
* Insomnia lasting more than 3 months, with episodes of at least 3 times a week.
* Regarding the pharmacology or medication indicated for sleep:
* They do not want to take the medication recommended by the doctor who is treating them.
* Do not change their usual drug regimen, if they were already taking medication to sleep.
* They are not taxed to take medication.
* Having ruled out other pathologies related to sleep through:
* Respiratory polygraphy to rule out sleep-related respiratory pathologies (SAHS).
* screening to rule out motor sleep disorders.
* screening to rule out circadian sleep disorders.
* screening to rule out serious psychiatric disorders (depression, anxiety, general psychopathology): BDI-II (Beck Depression Inventory), BAI (Beck Anxiety Inventory), SCL-90.
* Obtain a score greater than 7 points (clinical-subclinical insomnia).
* Problems initiating or maintaining sleep, associated with daytime consequences; and not attributable to environmental circumstances.
* Insomnia lasting more than 3 months, with episodes of at least 3 times a week.
* Regarding the pharmacology or medication indicated for sleep:
* They do not want to take the medication recommended by the doctor who is treating them.
* Do not change their usual drug regimen, if they were already taking medication to sleep.
* They are not taxed to take medication.
* Having ruled out other pathologies related to sleep through:
* Respiratory polygraphy to rule out sleep-related respiratory pathologies (SAHS).
* screening to rule out motor sleep disorders.
* screening to rule out circadian sleep disorders.
* screening to rule out serious psychiatric disorders (depression, anxiety, general psychopathology): BDI-II (Beck Depression Inventory), BAI (Beck Anxiety Inventory), SCL-90.
* Obtain a score greater than 7 points (clinical-subclinical insomnia).
Exclusion Criteria
* Obtain a score of less than 7 (clinically insignificant insomnia) in the ISI test (Insomnia Severity Index).
* The result of the respiratory polygraphy is positive, confirming a sleep-disordered breathing.
* The screening tests for the detection of motor sleep disorders, respiratory sleep disorders or circadian disorders are positive.
* The Screening detects serious psychiatric illnesses such as major depressive disorder or bipolar disorders is positive.
* Suffering or having suffered from any central neurological pathology, stroke, aneurysm...
* Having suffered skull fractures.
* Having undergone surgery in the last 6 months and that insomnia has started as a result of it.
* The result of the respiratory polygraphy is positive, confirming a sleep-disordered breathing.
* The screening tests for the detection of motor sleep disorders, respiratory sleep disorders or circadian disorders are positive.
* The Screening detects serious psychiatric illnesses such as major depressive disorder or bipolar disorders is positive.
* Suffering or having suffered from any central neurological pathology, stroke, aneurysm...
* Having suffered skull fractures.
* Having undergone surgery in the last 6 months and that insomnia has started as a result of it.
Minimum Eligible Age
18 Years
Maximum Eligible Age
65 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Corporacion Parc Tauli
OTHER
Sponsor Role
collaborator
Escoles Universitaries Gimbernat
OTHER
Sponsor Role
lead
Responsible Party
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Maider Sánchez Padilla
Principal Investigator
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Maider Sánchez-Padilla, MSc
Role: PRINCIPAL_INVESTIGATOR
Escoles Universitaries Gimbernat
Laura Vigil-Gimenez, PhD
Role: STUDY_DIRECTOR
Corporación Parc Taulí
Maria José Masdeu-Margalef, PhD
Role: STUDY_DIRECTOR
Corporación Parc Taulí
Locations
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Escoles Universitaries Gimbernat
Sant Cugat del Vallès, Barcelona, Spain
Site Status
RECRUITING
Countries
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Spain
Central Contacts
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Facility Contacts
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References
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Equihua-Benitez AC, Guzman-Vasquez K, Drucker-Colin R. Understanding sleep-wake mechanisms and drug discovery. Expert Opin Drug Discov. 2017 Jul;12(7):643-657. doi: 10.1080/17460441.2017.1329818. Epub 2017 May 22.
Reference Type
BACKGROUND
Riemann D, Spiegelhalder K, Feige B, Voderholzer U, Berger M, Perlis M, Nissen C. The hyperarousal model of insomnia: a review of the concept and its evidence. Sleep Med Rev. 2010 Feb;14(1):19-31. doi: 10.1016/j.smrv.2009.04.002. Epub 2009 May 28.
Reference Type
BACKGROUND
Durmer JS, Dinges DF. Neurocognitive consequences of sleep deprivation. Semin Neurol. 2005 Mar;25(1):117-29. doi: 10.1055/s-2005-867080.
Reference Type
BACKGROUND
Riemann D, Nissen C, Palagini L, Otte A, Perlis ML, Spiegelhalder K. The neurobiology, investigation, and treatment of chronic insomnia. Lancet Neurol. 2015 May;14(5):547-58. doi: 10.1016/S1474-4422(15)00021-6. Epub 2015 Apr 12.
Reference Type
BACKGROUND
Merino-Andreu M, Alvarez-Ruiz de Larrinaga A, Madrid-Perez JA, Martinez-Martinez MA, Puertas-Cuesta FJ, Asencio-Guerra AJ, Romero Santo-Tomas O, Jurado-Luque MJ, Segarra-Isern FJ, Canet-Sanz T, Gimenez-Rodriguez P, Teran-Santos J, Alonso-Alvarez ML, Garcia-Borreguero Diaz-Varela D, Barriuso-Esteban B. [Healthy sleep: evidence and guidelines for action. Official document of the Spanish Sleep Society]. Rev Neurol. 2016 Oct 3;63(s02):1. Spanish.
Reference Type
BACKGROUND
Nofzinger EA, Buysse DJ, Germain A, Price JC, Miewald JM, Kupfer DJ. Functional neuroimaging evidence for hyperarousal in insomnia. Am J Psychiatry. 2004 Nov;161(11):2126-8. doi: 10.1176/appi.ajp.161.11.2126.
Reference Type
BACKGROUND
Halasz P, Bodizs R, Parrino L, Terzano M. Two features of sleep slow waves: homeostatic and reactive aspects--from long term to instant sleep homeostasis. Sleep Med. 2014 Oct;15(10):1184-95. doi: 10.1016/j.sleep.2014.06.006. Epub 2014 Jul 8.
Reference Type
BACKGROUND
Bastien CH, St-Jean G, Morin CM, Turcotte I, Carrier J. Chronic psychophysiological insomnia: hyperarousal and/or inhibition deficits? An ERPs investigation. Sleep. 2008 Jun;31(6):887-98. doi: 10.1093/sleep/31.6.887.
Reference Type
BACKGROUND
Sateia MJ. International classification of sleep disorders-third edition: highlights and modifications. Chest. 2014 Nov;146(5):1387-1394. doi: 10.1378/chest.14-0970.
Reference Type
BACKGROUND
Morgenthaler T, Alessi C, Friedman L, Owens J, Kapur V, Boehlecke B, Brown T, Chesson A Jr, Coleman J, Lee-Chiong T, Pancer J, Swick TJ; Standards of Practice Committee; American Academy of Sleep Medicine. Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: an update for 2007. Sleep. 2007 Apr;30(4):519-29. doi: 10.1093/sleep/30.4.519.
Reference Type
BACKGROUND
Riha RL. Diagnostic approaches to respiratory sleep disorders. J Thorac Dis. 2015 Aug;7(8):1373-84. doi: 10.3978/j.issn.2072-1439.2015.08.28.
Reference Type
BACKGROUND
Thorpy MJ. Classification of sleep disorders. Neurotherapeutics. 2012 Oct;9(4):687-701. doi: 10.1007/s13311-012-0145-6.
Reference Type
BACKGROUND
D'Alonzo GE, Krachman SL. Circadian rhythm sleep disorders. J Am Osteopath Assoc. 2000 Aug;100(8 Suppl):S15-21.
Reference Type
BACKGROUND
Medrano-Martinez P, Ramos-Platon MJ. [Cognitive and emotional alterations in chronic insomnia]. Rev Neurol. 2016 Feb 16;62(4):170-8. Spanish.
Reference Type
BACKGROUND
Nijs J, Mairesse O, Neu D, Leysen L, Danneels L, Cagnie B, Meeus M, Moens M, Ickmans K, Goubert D. Sleep Disturbances in Chronic Pain: Neurobiology, Assessment, and Treatment in Physical Therapist Practice. Phys Ther. 2018 May 1;98(5):325-335. doi: 10.1093/ptj/pzy020.
Reference Type
BACKGROUND
Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL. Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med. 2017 Feb 15;13(2):307-349. doi: 10.5664/jcsm.6470.
Reference Type
BACKGROUND
Riemann D, Voderholzer U, Spiegelhalder K, Hornyak M, Buysse DJ, Nissen C, Hennig J, Perlis ML, van Elst LT, Feige B. Chronic insomnia and MRI-measured hippocampal volumes: a pilot study. Sleep. 2007 Aug;30(8):955-8. doi: 10.1093/sleep/30.8.955.
Reference Type
BACKGROUND
Molen YF, Carvalho LB, Prado LB, Prado GF. Insomnia: psychological and neurobiological aspects and non-pharmacological treatments. Arq Neuropsiquiatr. 2014 Jan;72(1):63-71. doi: 10.1590/0004-282X20130184.
Reference Type
BACKGROUND
Kingston J, Raggio C, Spencer K, Stalaker K, Tuchin PJ. A review of the literature on chiropractic and insomnia. J Chiropr Med. 2010 Sep;9(3):121-6. doi: 10.1016/j.jcm.2010.03.003.
Reference Type
BACKGROUND
Benca RM. Diagnosis and treatment of chronic insomnia: a review. Psychiatr Serv. 2005 Mar;56(3):332-43. doi: 10.1176/appi.ps.56.3.332.
Reference Type
BACKGROUND
Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008 Oct 15;4(5):487-504.
Reference Type
BACKGROUND
Ohayon MM. Epidemiology of insomnia: what we know and what we still need to learn. Sleep Med Rev. 2002 Apr;6(2):97-111. doi: 10.1053/smrv.2002.0186.
Reference Type
BACKGROUND
Morin CM, Benca R. Chronic insomnia. Lancet. 2012 Mar 24;379(9821):1129-41. doi: 10.1016/S0140-6736(11)60750-2. Epub 2012 Jan 20.
Reference Type
BACKGROUND
Ohayon MM, Sagales T. Prevalence of insomnia and sleep characteristics in the general population of Spain. Sleep Med. 2010 Dec;11(10):1010-8. doi: 10.1016/j.sleep.2010.02.018. Epub 2010 Nov 18.
Reference Type
BACKGROUND
Gronli J, Soule J, Bramham CR. Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Front Behav Neurosci. 2014 Jan 21;7:224. doi: 10.3389/fnbeh.2013.00224. eCollection 2013.
Reference Type
BACKGROUND
Meerlo P, Koehl M, van der Borght K, Turek FW. Sleep restriction alters the hypothalamic-pituitary-adrenal response to stress. J Neuroendocrinol. 2002 May;14(5):397-402. doi: 10.1046/j.0007-1331.2002.00790.x.
Reference Type
BACKGROUND
Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W, Yu F. A review of sleep disorders and melatonin. Neurol Res. 2017 Jun;39(6):559-565. doi: 10.1080/01616412.2017.1315864. Epub 2017 May 1.
Reference Type
BACKGROUND
Lomeli HA, Perez-Olmos I, Talero-Gutierrez C, Moreno CB, Gonzalez-Reyes R, Palacios L, de la Pena F, Munoz-Delgado J. Sleep evaluation scales and questionaries: a review. Actas Esp Psiquiatr. 2008 Jan-Feb;36(1):50-9.
Reference Type
BACKGROUND
Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001 Jul;2(4):297-307. doi: 10.1016/s1389-9457(00)00065-4.
Reference Type
BACKGROUND
Dodds KL, Miller CB, Kyle SD, Marshall NS, Gordon CJ. Heart rate variability in insomnia patients: A critical review of the literature. Sleep Med Rev. 2017 Jun;33:88-100. doi: 10.1016/j.smrv.2016.06.004. Epub 2016 Jun 28.
Reference Type
BACKGROUND
Qaseem A, Kansagara D, Forciea MA, Cooke M, Denberg TD; Clinical Guidelines Committee of the American College of Physicians. Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2016 Jul 19;165(2):125-33. doi: 10.7326/M15-2175. Epub 2016 May 3.
Reference Type
BACKGROUND
McCall WV. Cognitive behavioral therapy for insomnia (CBT-I): What is known, and advancing the science by avoiding the pitfalls of the placebo effect. Sleep Med Rev. 2018 Apr;38:1-2. doi: 10.1016/j.smrv.2017.05.001. Epub 2017 May 5. No abstract available.
Reference Type
BACKGROUND
Shergis JL, Ni X, Jackson ML, Zhang AL, Guo X, Li Y, Lu C, Xue CC. A systematic review of acupuncture for sleep quality in people with insomnia. Complement Ther Med. 2016 Jun;26:11-20. doi: 10.1016/j.ctim.2016.02.007. Epub 2016 Feb 18.
Reference Type
BACKGROUND
Bialosky JE, Bishop MD, Price DD, Robinson ME, George SZ. The mechanisms of manual therapy in the treatment of musculoskeletal pain: a comprehensive model. Man Ther. 2009 Oct;14(5):531-8. doi: 10.1016/j.math.2008.09.001. Epub 2008 Nov 21.
Reference Type
BACKGROUND
Lozano Lopez C, Mesa Jimenez J, de la Hoz Aizpurua JL, Pareja Grande J, Fernandez de Las Penas C. Efficacy of manual therapy in the treatment of tension-type headache. A systematic review from 2000-2013. Neurologia. 2016 Jul-Aug;31(6):357-69. doi: 10.1016/j.nrl.2014.01.002. Epub 2014 May 22. English, Spanish.
Reference Type
BACKGROUND
Schmid A, Brunner F, Wright A, Bachmann LM. Paradigm shift in manual therapy? Evidence for a central nervous system component in the response to passive cervical joint mobilisation. Man Ther. 2008 Oct;13(5):387-96. doi: 10.1016/j.math.2007.12.007. Epub 2008 Mar 3.
Reference Type
BACKGROUND
Shi X, Rehrer S, Prajapati P, Stoll ST, Gamber RG, Downey HF. Effect of cranial osteopathic manipulative medicine on cerebral tissue oxygenation. J Am Osteopath Assoc. 2011 Dec;111(12):660-6.
Reference Type
BACKGROUND
Morin CM, Belleville G, Belanger L, Ivers H. The Insomnia Severity Index: psychometric indicators to detect insomnia cases and evaluate treatment response. Sleep. 2011 May 1;34(5):601-8. doi: 10.1093/sleep/34.5.601.
Reference Type
BACKGROUND
Veqar Z, Hussain ME. Validity and reliability of insomnia severity index and its correlation with pittsburgh sleep quality index in poor sleepers among Indian university students. Int J Adolesc Med Health. 2017 Jan 7;32(1):/j/ijamh.2020.32.issue-1/ijamh-2016-0090/ijamh-2016-0090.xml. doi: 10.1515/ijamh-2016-0090.
Reference Type
BACKGROUND
Curtis BJ, Williams PG, Jones CR, Anderson JS. Sleep duration and resting fMRI functional connectivity: examination of short sleepers with and without perceived daytime dysfunction. Brain Behav. 2016 Sep 15;6(12):e00576. doi: 10.1002/brb3.576. eCollection 2016 Dec.
Reference Type
RESULT
Jakel A, von Hauenschild P. Therapeutic effects of cranial osteopathic manipulative medicine: a systematic review. J Am Osteopath Assoc. 2011 Dec;111(12):685-93.
Reference Type
RESULT
Hurley DA, Eadie J, O'Donoghue G, Kelly C, Lonsdale C, Guerin S, Tully MA, van Mechelen W, McDonough SM, Boreham CA, Heneghan C, Daly L. Physiotherapy for sleep disturbance in chronic low back pain: a feasibility randomised controlled trial. BMC Musculoskelet Disord. 2010 Apr 16;11:70. doi: 10.1186/1471-2474-11-70.
Reference Type
RESULT
Levendowski DJ, Popovic D, Berka C, Westbrook PR. Retrospective cross-validation of automated sleep staging using electroocular recording in patients with and without sleep disordered breathing. Int Arch Med. 2012 Jun 25;5(1):21. doi: 10.1186/1755-7682-5-21.
Reference Type
RESULT
Short NA, Allan NP, Raines AM, Schmidt NB. The effects of an anxiety sensitivity intervention on insomnia symptoms. Sleep Med. 2015 Jan;16(1):152-9. doi: 10.1016/j.sleep.2014.11.004. Epub 2014 Nov 25.
Reference Type
RESULT
Jackowska M, Dockray S, Endrighi R, Hendrickx H, Steptoe A. Sleep problems and heart rate variability over the working day. J Sleep Res. 2012 Aug;21(4):434-40. doi: 10.1111/j.1365-2869.2012.00996.x. Epub 2012 Feb 7.
Reference Type
RESULT
Toro-Velasco C, Arroyo-Morales M, Fernandez-de-Las-Penas C, Cleland JA, Barrero-Hernandez FJ. Short-term effects of manual therapy on heart rate variability, mood state, and pressure pain sensitivity in patients with chronic tension-type headache: a pilot study. J Manipulative Physiol Ther. 2009 Sep;32(7):527-35. doi: 10.1016/j.jmpt.2009.08.011.
Reference Type
RESULT
Cutler MJ, Holland BS, Stupski BA, Gamber RG, Smith ML. Cranial manipulation can alter sleep latency and sympathetic nerve activity in humans: a pilot study. J Altern Complement Med. 2005 Feb;11(1):103-8. doi: 10.1089/acm.2005.11.103.
Reference Type
RESULT
Miana L, Bastos VH, Machado S, Arias-Carrion O, Nardi AE, Almeida L, Ribeiro P, Machado D, King H, Silva JG. Changes in alpha band activity associated with application of the compression of fourth ventricular (CV-4) osteopathic procedure: a qEEG pilot study. J Bodyw Mov Ther. 2013 Jul;17(3):291-6. doi: 10.1016/j.jbmt.2012.10.002. Epub 2012 Nov 16.
Reference Type
RESULT
Other Identifiers
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2019/302
Identifier Type: -
Identifier Source: org_study_id
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PHASE4