Treatment of Insomnia Secondary to Chronic Pain

NCT ID: NCT00127790

Last Updated: 2012-10-17

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-06-30

Study Completion Date

2008-11-30

Brief Summary

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Several studies have shown that behavioral therapy for chronic pain can be beneficial for chronic pain and that behavioral therapy for insomnia can be beneficial for insomnia. However, seldom do chronic pain patients with insomnia receive a behavioral treatment for insomnia. The purpose of this study is to evaluate whether treatment for insomnia is helpful for pain and whether treatment for pain is helpful for insomnia. It will also assess whether a combined treatment is any more or less effective for pain or for sleep. Finally, the study will assess whether any of these treatments leads to improvements in immune function.

Detailed Description

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The investigators' primary goal is to assess the extent to which three forms of cognitive-behavioral treatment (CBT for insomnia, CBT for pain, and combined insomnia \& pain) diminishes insomnia symptoms in patients with chronic pain compared to a group not receiving CBT. This will be evaluated in a randomized trial with before and after evaluations using standard sleep diary measures of sleep continuity.

The investigators' secondary goal is to assess whether treatment responses to any of the interventions are associated with alterations in immune function.

The investigators' tertiary goals are to evaluate whether improved sleep has effects on patient reports of pain severity, frequency, and tolerability as well as on mood and quality of life.

Conditions

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Insomnia Pain

Keywords

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Insomnia Sleep Pain Pain, Chronic Behavior Therapy CBT CBT-I cognitive-behavioral

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CBT for Insomnia (CBT-I)

Cognitive-Behavioral Therapy for Insomnia (CBT-I)consisting of 10 individual sessions and including sleep education, sleep restriction therapy, stimulus control therapy, sleep hygiene, cognitive therapy, relaxation training and relapse prevention.

Group Type ACTIVE_COMPARATOR

CBT for Insomnia (CBT-I)

Intervention Type BEHAVIORAL

CBT for Pain (CBT-P)

Cognitive-Behavioral Therapy for Pain (CBT-P)consisting of 10 individual sessions and including pain education, pacing strategies, problem solving, goal setting, cognitive therapy, relaxation training and relapse prevention.

Group Type ACTIVE_COMPARATOR

CBT for Pain (CBT-P)

Intervention Type BEHAVIORAL

CBT for Insomnia & Pain (CBT-I/P)

Combined Cognitive-Behavioral Therapy for Insomnia \& Cognitive-Behavioral Therapy for Pain (CBT-I/P)over 10 individual sessions.

Group Type EXPERIMENTAL

CBT for Insomnia (CBT-I)

Intervention Type BEHAVIORAL

CBT for Pain (CBT-P)

Intervention Type BEHAVIORAL

Wait-List Control (WL)

Waitlist Control condition (WL) with no contact during the intervention period.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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CBT for Insomnia (CBT-I)

Intervention Type BEHAVIORAL

CBT for Pain (CBT-P)

Intervention Type BEHAVIORAL

Other Intervention Names

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Cognitive-Behavioral Therapy for Insomnia (CBT-I) Cognitive-Behavioral Therapy for Pain (CBT-P)

Eligibility Criteria

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Inclusion Criteria

* Ages 35-75
* Chronic non-malignant painful condition of the spine of \> 6 months duration
* Insomnia (\> 30 minutes sleep latency and/or wake after sleep onset time for \> 3 days/week for \> 6 months)
* Insomnia developed after the onset of the painful condition
* Preferred sleep phase between 10:00 p.m. and 8:00 am
* On stable medical regimen for medical and pain conditions (no surgery planned)
* Willingness to discontinue hypnotic medications

Exclusion Criteria

* Unstable medical or psychiatric illness
* History of seizures
* Evidence of active illicit substance use or fitting criteria for ethanol (ETOH) abuse or dependence
* Symptoms suggestive of sleep disorders other than insomnia
* Polysomnographic data indicating sleep disorders other than insomnia
* Inadequate language comprehension
* Fibromyalgia
* Pregnancy
Minimum Eligible Age

35 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute of Neurological Disorders and Stroke (NINDS)

NIH

Sponsor Role collaborator

National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

National Institute of Nursing Research (NINR)

NIH

Sponsor Role collaborator

University of Rochester

OTHER

Sponsor Role lead

Responsible Party

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Wilfred Pigeon

Asst Prof

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Wilfred R. Pigeon, Ph.D

Role: PRINCIPAL_INVESTIGATOR

University of Rochester

Locations

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University of Rochester Sleep Research Laboratory

Rochester, New York, United States

Site Status

Countries

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United States

Other Identifiers

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F32NS049789

Identifier Type: NIH

Identifier Source: secondary_id

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K23NR010408

Identifier Type: NIH

Identifier Source: secondary_id

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R21AG023956; R24AG031089

Identifier Type: OTHER

Identifier Source: secondary_id

R21AG023956

Identifier Type: NIH

Identifier Source: secondary_id

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160743209

Identifier Type: -

Identifier Source: org_study_id