Assocaiton Between Uric Acid Trajecteries and Remission of NAFLD in NAFLD Individuals

NCT ID: NCT05245890

Last Updated: 2022-02-18

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 2000 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-03-01
• Study Completion Date: 2024-03-01

Brief Summary

Uric acid is the end product of dietary or endogenous purines degradation, and hyperuricemia is one of the most common metabolic disorders. A growing body of evidence, comprising a great deal of cross-sectional studies and several prospective ones, also indicates that hyperuricemia is associated with increased prevalence, incidence, and disease severity of non-alcoholic fatty liver disease (NAFLD).

Capitalizing on a cohort study in China, the investigators are aimed to assess the associations of SUA trajecteries with remission of NAFLD in NAFLD individuals and examined whether the association differs across subpopulations.

Detailed Description

A cohort study was conducted to evaluate the relationship between the SUA trajecteries and remission of NAFLD. The study enrolled employees who were attending their annual health examination. Furrhermore, the investigators are aimed to explore whether the association differs across subpopulations.

Conditions

Non-Alcoholic Fatty Liver Disease; Hyperuricemia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. age >=18 years;

2. agree to be enrolled in this study.

Exclusion Criteria

1. those taking antihypertensive or antidiabetic agents, lipid-lowing agents, or hypouricemic agents;

2. those with alcohol consumption greater than 140 g/week for men and 70 g/week for women;

3. those with a history of other known causes of chronic liver disease such as viral hepatitis or autoimmune hepatitis, and those using hepatotoxic medications.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The First Afliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

UNKNOWN

Sponsor Role: collaborator

Ningbo No. 1 Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

uric acid trajecteries2022

Identifier Type: -

Identifier Source: org_study_id