Comparing the Efficacy of Visible Light-Ultraviolet A1 Light Versus Narrowband-Ultraviolet B on Generalized Vitiligo

NCT ID: NCT05238077

Last Updated: 2022-02-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

1 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-26

Study Completion Date

2020-06-02

Brief Summary

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As part of this study, you may have a procedure called phototherapy which involves either VL-UVA or NB-UVB irradiation. NB-UVB phototherapy is not experimental in vitiligo, but use of VL-UVA1 phototherapy in vitiligo is.

The purpose of this pilot study is to determine whether VL-UVA1 or NB-UVB phototherapy more efficiently induces repigmentation in patients with generalized vitiligo.

Detailed Description

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Conditions

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Generalized Vitiligo

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

The subject serves as their own control.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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VL-UVA1 vs NB-UVB

Participants will be treated with both VL-UVA and NB-UVB on different areas

Group Type OTHER

Visible Light-Ultraviolet A Light or Narrowband-Ultraviolet B phototherapy

Intervention Type PROCEDURE

Patients will have different kinds of light shined on different areas

Interventions

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Visible Light-Ultraviolet A Light or Narrowband-Ultraviolet B phototherapy

Patients will have different kinds of light shined on different areas

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Subjects ≥ 18 years of age with a diagnosis of generalized vitiligo
* Subjects on a stable topical/oral regimen for the past 3 months and continuing on a stable regimen
* Subjects able to understand the requirements of the study
* Subjects able and willing to sign informed consent

Exclusion Criteria

* Subjects on photosensitizing medications
* Subjects receiving any concurrent phototherapy
* Subjects who plan to use tanning parlors or expose themselves to excess sunlight
* Subjects with known photosensitivity disorder
* Subjects with apparent phototoxicity
* Subjects with unstable vitiligo
* Subjects currently using bleaching agents
* Subjects who are pregnant, lactating, or planning on becoming pregnant
* Subjects who in the opinion of the investigator/sub-investigator, are not appropriate candidates for this study
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Henry Ford Health System

OTHER

Sponsor Role lead

Responsible Party

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Iltefat Hamzavi

Director Investigator Initiated Studies

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Iltefat Hamzavi, M.D.

Role: PRINCIPAL_INVESTIGATOR

Henry Ford HS

Locations

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Department of Dermatology, Henry Ford Medical Center, 3031 West Grand Boulevard,

Detroit, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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11973

Identifier Type: -

Identifier Source: org_study_id

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