The Risk Factors for Acute Radiation Pneumonitis in Patients With Prior Receipt of Immune Checkpoint Inhibitors

NCT ID: NCT05219851

Last Updated: 2024-03-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-01

Study Completion Date

2025-10-31

Brief Summary

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The purpose of this non-interventional study is to collect data on the risk factors for acute radiation pneumonitis in patients with prior receipt of immune checkpoint inhibitors.

Detailed Description

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1. Incidence of acute radiation pneumonitis (aRPs) in in patients with prior receipt of immune checkpoint inhibitors.
2. Risk factors (especially analysis of the dosimetric risk factor) which may affect the product of aRPs events.
3. Establish a model to predict aRPs and guide clinical treatment.

Conditions

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Cancer Patients

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Cancer patients underwent thoracic intensity-modulated radiotherapy

Cancer patients underwent thoracic intensity-modulated radiotherapy, previously received ICIs

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

1. Pathologically or cytologically confirmed malignant tumor
2. Cancer patients with previously received ICIs underwent thoracic intensity-modulated radiotherapy

Exclusion Criteria

1. Cancer patients did not receive immunotherapy before thoracic intensity-modulated radiotherapy
2. Non-thoracic radiotherapy patients
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hubei Cancer Hospital

OTHER

Sponsor Role lead

Responsible Party

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HAN GUANG

Clinical Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hubei Cancer Hospital

Wuhan, Hubei, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Guang Han, MD.;Ph.D

Role: CONTACT

13886048178

Facility Contacts

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Guang Han, MD.Phd

Role: primary

13886048178

Other Identifiers

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HBCH-RT-2022-RP

Identifier Type: -

Identifier Source: org_study_id

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