Stereotactic Volumetric Radiotherapy in Prostate Cancer

NCT ID: NCT02423889

Last Updated: 2016-05-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a prospective, single arm, phase II, multicentric study. It evaluates the acute and late toxicity after stereotactic radiotherapy in low risk prostate cancer patients. All participants receive a total dose of 36.25 Gy in 5 fractions, twice a week, 7.25 Gy per fraction.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Prostate Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Stereotactic radiotherapy with a total dose of 36.25 Gy in 5 fractions (7.25 Gy per fraction, 2 fractions per week) in low risk prostate cancer patients is delivered to evaluate acute and subacute toxicty

Group Type EXPERIMENTAL

Radiotherapy

Intervention Type RADIATION

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Radiotherapy

Intervention Type RADIATION

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Histology of prostate adenocarcinoma
* Age≥ 18 years
* Life expectancy≥ 10 years
* Clinical negative nodes (N0)
* No metastasis presence (M0)
* No previous pelvic radiation therapy
* Total PSA≤10 ng/ml
* Gleason score ≤ 6
* T1-2
* ≤ 3 positive biopsy at prostatic mapping
* Signed informed consent

Exclusion Criteria

* Positive nodes (N+) or metastatic disease (M+)
* Inflammatory bowel disease, collagen- vascular disorders or active autoimmune disorders
* Anticoagulant treatment in progress
* Hip or pelvic presence of medical devices that could prevent a correct image acquisition
* Symptomatic haemorrhoidal disease
* Adverse reactions to iodinate or paramagnetic contrast media
* Previous malignant cancer, except basocellular skin tumour or other tumours healed since 5 years
* Previous pelvic radiotherapy
* Psychiatric disorder that preclude to obtain informed consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Stefano Vagge

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

IRCCS AOU San Martino-IST

Genoa, GE, Italy

Site Status

AO Città della salute e della scienza - Molinette

Turin, TO, Italy

Site Status

Istituto del Radio "O. Alberti" Spedali Civili - University of Brescia

Brescia, , Italy

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Italy

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

RITS13.001

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.