Anti-tumor Immune Response in Patients With Cancer Undergoing Radiation Therapy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

139 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-07-08

Study Completion Date

2022-08-09

Brief Summary

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This research trial studies the effect of radiation therapy on tumor immunity. Standard radiation therapy destroys tumor cells. In response to tumor cell death caused by radiation therapy, the body has an ability to stimulate an anti-tumor response (immunity), but this response is often ineffective in shrinking tumor tissue. Collecting samples of blood from patients before, during, and after radiation therapy to study in the laboratory may help doctors learn more about the effects of radiation therapy on anti-tumor response.

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Detailed Description

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PRIMARY OBJECTIVES:

I. To assess the effect of radiation therapy on tumor immunity.

OUTLINE:

Samples of blood are collected before, during, and within two weeks after radiation therapy and then stored for analysis of anti-tumor immunity.

Conditions

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Malignant Neoplasm

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Ancillary-Correlative (blood banking)

Samples of blood are collected before, during, and within two weeks after radiation therapy and then stored for analysis of anti-tumor immunity.

cytology specimen collection procedure

Intervention Type OTHER

Undergo blood sample collection

laboratory biomarker analysis

Intervention Type OTHER

Correlative studies

Interventions

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cytology specimen collection procedure

Undergo blood sample collection

Intervention Type OTHER

laboratory biomarker analysis

Correlative studies

Intervention Type OTHER

Other Intervention Names

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cytologic sampling

Eligibility Criteria

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Inclusion Criteria

* Signed and dated Institutional Review Board (IRB)-approved Informed Consent form for the study
* Received an explanation of the study, including satisfactory answers to all questions related to the proposed research
* Is undergoing physician directed radiation treatment