NFL Dynamics as a Predictor Factor in Patients With Out of Hospital Cardiac Arrest

NCT ID: NCT05218278

Last Updated: 2025-03-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2026-12-31

Brief Summary

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To investigate the pharmacodynamics of light chain of NFL in patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.

Detailed Description

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To investigate the serum levels of the light chain of NFL at different time points after ICU admission (12, 24, 30, 36, 42, 48 hours after ICU admission) patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.

Conditions

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Out-Of-Hospital Cardiac Arrest Neurological Injury

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with favorable neurlogical outcome

CPC 1/2

No interventions assigned to this group

Patients with non-favorable neurological outcome

CPC3-5

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU

Exclusion Criteria

* trauma, drowning, electrocution, less than 18 years of age,
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Medical Centre Maribor

OTHER

Sponsor Role lead

Responsible Party

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Matej Strnad

Associate Proffessor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Matej Strnad, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University medical cenetr Maribor

Locations

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University medical center Maribor

Maribor, , Slovenia

Site Status RECRUITING

Countries

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Slovenia

Central Contacts

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Matej Strnad, MD, PhD

Role: CONTACT

+38651225448

Facility Contacts

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Andrej Markota, MD, PhD

Role: primary

+38523212849

Other Identifiers

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IRP-2021/01-01

Identifier Type: -

Identifier Source: org_study_id

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