Effectiveness of a Telerehabilitation Program in Ankle Sprain

NCT ID: NCT05217173

Last Updated: 2023-01-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 82 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-02-01
• Study Completion Date: 2022-10-30

Brief Summary

Ankle sprain is the most common sprain. Their care entails a high cost due to the incapacity for work that it generates. An early and timely intervention for the treatment of ankle sprain reduces the days of disability and functional recovery is faster. Strategies must be generated to provide timely care in rehabilitation. Telerehabilitation is a viable option to partially solve this problem. The purpose of this study is evaluate the effectiveness of functional ankle recovery after a telerehabilitation program in patients with sprain in the first level of care. Material and method: Controlled clinical trial, 92 subjects with grade 1 and 2 ankle sprain will be included; they will be divided into two groups, with randomized allocation. One group will receive usual care (n = 41) for ankle sprain and another will receive regular care plus telerehabilitation (n = 41) through a digital platform course, it will consist of video and written instructions. Foot and Ankle Ability Measure (FAAM) will be measured at baseline and weekly, until completing 4 weeks. Group experience: The group is trained for the development of the contents and the rehabilitation program, with clinical experience in evaluation, treatment and rehabilitation of ankle sprain.

Detailed Description

Ankle sprain (AS) is a soft tissue injury caused by a forced twisting movement that exceeds the normal limits of the joint. This injury can range from minimal tissue distention to complete tissue rupture, it is manifested clinically by pain, edema, and functional limitation of the joint.

AS is the injury most related to physically active people, the worldwide incidence is estimated at 1 in every 10,000 people, it represents 15 to 20% of all sports injuries and most frequently affects young adults, its frequency has led it to be considered a benign condition, however, 20% of cases will develop complications.

After presenting a AS, the effects on health and costs of care are frequently underestimated by health personnel and the patient. The economic costs of your care are highly variable, they depend on the severity of the injury and the therapeutic strategy used; in most cases, it takes several days of disability for the injured limb to recover, causing absenteeism from work. Likewise, the frequency and variability with which the treatment of is selected can affect the recovery time and the quality of life of the patient.

The most important component of treatment for AS is rehabilitation, since it accelerates healing and return to desired activities, however, a large number of patients do not receive this therapeutic component adequately. Currently there are changes in the way of care for patients, largely due to the health contingency caused by Coronavirus disease 2019 (COVID-19), where social distance is a recommended action, for this reason, telemedicine is a strategy that can help the care of patients with conditions that require rehabilitation; therefore, some countries included digital practice within their health system.

When introducing a new therapeutic strategy, the economic and health effects, positive and negative, must be taken into account; cost-effectiveness studies are useful to know these effects. There are few cost-effectiveness studies for AS where telerehabilitation is compared with usual treatments at the first level of care. The evidence on measures of the effectiveness of Interventions through the telerehabilitation of AS is limited. The results also suggest that, in low- and middle-income countries, these pieces of evidence are even more limited. Some studies have shown that a distance intervention in orthopedic consultations is equal to or more cost-effective than standard consultations, where patients must attend a face-to-face consultation with the doctor.

What is known is that early rehabilitation as an optimized treatment for ankle sprain reduces treatment costs and reduces complications. However, the effectiveness of a telerehabilitation intervention for AS like the one proposed in this protocol is still unknown.

The research question is: what is the effectiveness in functional ankle recovery after a tele-rehabilitation program in patients with sprain in the first level of care, in a controlled and cost-effective clinical trial?

Our objective is: to evaluate the effectiveness in functional recovery of the ankle after a telerehabilitation program in patients with sprain grade 1-2 in the first level of care, in a controlled and cost-effectiveness clinical trial.

The investigators hypothesize: there will be the same or greater functional recovery of the ankle after a telerehabilitation program compared to the usual treatment in patients with sprain grade 1-2 in the first level of care.

Trial design: a controlled, randomized, pragmatic, single-blind and parallel clinical trial will be conducted. The independent variable will be the type of intervention (telerehabilitation vs usual care). The participants assigned to the telerehabilitation group will carry out a rehabilitation program using a mobile application, which will contain previously recorded videos with exercises that will serve as a guide for the rehabilitation activities. The duration of the program will be 30 minutes a day, 5 days a week for 4 weeks. The control group will be patients with usual care for ankle sprain, in the outpatient consultation of their medical care unit, they will receive instructions to follow from their doctors during the 4-week period.

The dependent variable will be the functionality perceived by the patient. A collaborator will perform the group assignment, the initial assessment of ankle functionality perceived by the patient and the induction to the use of the application on the cell phone in the case of patients assigned to the intervention group. Subsequent (weekly) evaluations of functional perception of the ankle will be carried out by another collaborator who will be blinded and will not know to which group the evaluated patient belongs.

The personnel who will invite and train patients to enter and use the telephone or internet application will be family medicine resident physicians.

Methods.

Scope of study: patients presenting in primary care for the diagnosis of AS grade 1 and 2.

Experimental group (Telerehabilitation Group): Intervention. Rehabilitation service that will be provided remotely through information and communication technologies. It will start within the first 72 hours of having started with the condition (ankle sprain); they will receive a rehabilitation program using a mobile application (through a digital platform course), which will contain previously recorded videos with exercises that will serve as a guide for rehabilitation activities. The duration of the program will be 30 minutes a day, 5 days a week for 4 weeks. The control group will be patients with usual care for ankle sprain, in the outpatient consultation of their medical care unit, they will receive instructions to follow from their doctors during the 4-week period.

The content of the rehabilitation program will consist of 2 modules: 1) Information module on the disease and self-care, 2) Exercise module (Stretching, strengthening and proprioception). The exercise program is based on the recommendations of national and international clinical practice guidelines. Additionally, the patient will be provided with a physical activity diary to assess adherence to treatment and the time the patient remains on the platform will be monitored.

Control Group: Regular medical attention by family doctor. Care service that is carried out by the family doctor. The medical care that the patient with an ankle sprain will carry out with the family doctor; medical care will consist of the approach that the doctor considers appropriate for the patient. The follow-up and time of disability will be the responsibility of the doctor in question.

Criteria for interrupting the assigned intervention:

• By request of the participant.
• Due to worsening of the condition.

Strategies to improve compliance with the intervention: a weekly reminder will be made by phone call to patients.

Interventions prohibited during the trial: perform other types of rehabilitation exercises that are not contemplated in the study.

Sample size: to calculate the sample size, a clinical difference is considered in the Foot and Ankle Ability Measure (FAAM) based on the Hoch's study, where rehabilitation is performed in patients with chronic ankle instability based on joint mobilization, considering a minimal clinically important difference for measure ankle function at 4 weeks, having a result prior to the rehabilitation intervention of 78.27 in the activities of daily living (ADL) of Foot and Ankle Ability Measure (FAAM) (Standard Deviation 12.62) and post-intervention of 87.3 (Standard Deviation 11.07), with a minimum detectable difference of 9.1 with a significance level of 5% and a power of 90%, performing a size calculation for the difference in paired means, with a consideration of estimated losses of 20%, so the sample size is 41 subjects per group.

Recruitment: patients with a grade 1 and 2 ankle sprain diagnosis who have attended the family medicine consultation at Family Medicine Unit will be identified. Identification will be carried out through the medical information and clinical file area of the Unit. Patients will be contacted by phone and will be scheduled the next day. The number of patients diagnosed with AS is sufficient and frequent in the Unit.

Allocation of interventions and blinding: it will be carried out by simple randomization; the randomization process will be carried out by an individual other than the one who will assign the groups. The randomization procedure will be generated with the Excel program; due to the nature of the intervention, the collaborator who will invite and enter the study subject cannot be blinded to the group assignment. Subsequent evaluations (weekly) where the response variables will be measured will be carried out by a different collaborator, who will be blinded from the group to which each study subject corresponds. The data analyst will remain blinded and will not know to which groups each study subject belongs. The circumstances that may unmask the data of the study subjects for both the evaluator and the data analyst, will be when the study subject is removed from the study for any reason.

Data collection methods: to ensure the quality of the data obtained, the evaluators (resident physicians) will receive training to know and master the clinical scales. The monitoring of the intervention will be supervised by the responsible researcher. The input of the data obtained will be examined twice before being entered into the data matrix to verify its congruence, this review will be carried out by a collaborating researcher, all those data that are not plausible or outside the established ranges of values, they will have to be corroborated. It is considered to make phone calls and send text messages via cell phone to remind patients to carry out the rehabilitation exercises, in this way, promote the retention of patients in the study and achieve complete follow-up to the rehabilitation program.

Data monitoring: the monitoring of the data will be carried out by the main researcher, who will not have contact with the study subjects, nor with the evaluators. Weekly, an intermediate analysis of the data obtained will be carried out by the main researcher, who will make the decision to end the study when the objectives are met.

Damage: the study subjects will have the opportunity to report any type of adverse or unforeseen effect at any time, the report, if spontaneous, can be made by telephone to the collaborators or the principal investigator. In addition, in the weekly evaluation, there will be the opportunity to express any type of adverse event secondary to the rehabilitation maneuver. In case of corroborating any adverse effect secondary to the intervention, timely attention to the treating physician will be managed.

Audit: the progress of the results will be audited by the project's tutorial committee every six months or when the project's tutor committee considers it. Progress in the results will be reported to the local ethics and institutional research committee every six months.

Ethics and dissemination: it has the approval of the Local Ethics and Research Committee of the Mexican Institute of Social Security.

Informed consent: informed consent will be obtained by the collaborators of the research project at the time of identifying and inviting the study subject, that is, it will not be obtained by the main researcher. The informed consent form is a document approved and granted by the Mexican Institute of Social Security, through the Ethics and Research Committee.

Confidentiality: the data will be collected by the collaborators of the research project. The data will be collected in a single database to which, initially, only collaborators will have access, later it will be shared with the main researcher for data monitoring. The data will be kept in a computer equipment to which only the main investigator has access, for no reason will it be shared with personnel outside the study in order to maintain the confidentiality of the data before, during and after the trial.

Data access: at the end of the trial, only researchers will be able to access the data. Collaborators will only know the final results.

Additional and post-study care: the patients who have participated in the trial are guaranteed care within the health institution, so that attention to any damage suffered by the trial, will be followed and care. No additional compensation is established.

Conditions

Ankle Sprain; Ankle Sprain 1St Degree; Ankle Sprain 2Nd Degree

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Intervention group

Rehabilitation service that will be provided remotely through information and communication technologies. It will start within the first 72 hours of having started with the condition (ankle sprain); They will receive a rehabilitation program using a mobile application (through a digital platform course), which will contain previously recorded videos with exercises that will serve as a guide for rehabilitation activities. The duration of the program will be 30 minutes a day, 5 days a week for 4 weeks.

The content of the rehabilitation program will consist of e modules: 1) Information module on the disease and self-care, 2) Exercise module (Stretching, strengthening and proprioception).

Group Type: EXPERIMENTAL

telerehabilitation

Intervention Type: OTHER

It will start within the first 72 hours of having started with the condition (ankle sprain); They will receive a rehabilitation program using a mobile application (through a digital platform course), which will contain previously recorded videos with exercises that will serve as a guide for rehabilitation activities. The duration of the program will be 30 minutes a day, 5 days a week for 4 weeks

Control group

Care service that is carried out by the Family Physician. The medical care that the patient with an ankle sprain will carry out with the Family Physician of the assigned office; Medical care will consist of the approach that the Doctor considers appropriate for the patient. The follow-up and time of disability will be the responsibility of the Physician in question

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

telerehabilitation

It will start within the first 72 hours of having started with the condition (ankle sprain); They will receive a rehabilitation program using a mobile application (through a digital platform course), which will contain previously recorded videos with exercises that will serve as a guide for rehabilitation activities. The duration of the program will be 30 minutes a day, 5 days a week for 4 weeks

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Beneficiaries of the Mexican Institute of Social Security
• Patients with grade 1 and 2 ankle sprain, and are within the first 72 hours of presenting it
• Over 18 years of age and under 61 (this age group is susceptible to receiving monetary transfers for medical disability due to being of working age).
• Who have formal employment with susceptibility to receive medical disability.
• That they agree to participate in the study and sign the informed consent.
• With a diagnosis of ankle sprain for the first time.
• That they have and know how to use a cell phone or computer, as well as its use with the internet.

Exclusion Criteria

• - With a history of previous ankle sprain.
• With time greater than 72 hours after starting with the ankle sprain.
• Patients with neurological disorders.
• Patients who cannot read or write.
• Retired patients.
• With leg or foot ulcers.
• Users of steroids administered orally or intravenously.
• Pre-existing and concomitant ankle arthritis or history of significant ipsilateral or contralateral lower extremity injury / condition, eg. lower extremity joint prostheses, or central or peripheral neurological disorders.
• Fibromyalgia
• Neuromuscular plaque disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Instituto Mexicano del Seguro Social

OTHER_GOV

Sponsor Role: lead

Responsible Party

Juan Figueroa-García

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Unidad de Medicina Familiar 21

Iztacalco, Mexico City, Mexico

Countries

Mexico

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Related Links

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Other Identifiers

R-2021-3609-037

Identifier Type: -

Identifier Source: org_study_id