Oral Health in Covid-19 Survivors

NCT ID: NCT05205694

Last Updated: 2022-01-25

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 210 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-09-20
• Study Completion Date: 2023-06-30

Brief Summary

Aims are to assess periodontal health and salivary stress/ immunity responses in COVID-19 survivors

Detailed Description

There are lack of data concerning oral health in COVID-19 survivors, nevertheless, many middle-aged patients with oral symptoms of Post-acute COVID-19 report xerostomia and taste impairment and suffer from oral hypofunction, thus may be susceptible to periodontitis and oral frailty. Post-acute or long COVID-19 is/would be the health hallmark of post-COVID-19 era, manifested as a multiplicity of clinical problems and requiring conceptual framework aiming at multidisciplinary health preserving activities. There are various factors which may affect oral and periodontal health in post-COVID-19 era, such as disruption of dental professional care due to the fear of infection, virus-induced disturbance of oral homeostasis and, as a common denominator- COVID-19-induced psychological stress. Expected results would not just offer epidemiological data but also, mechanistic background for defining risks and modified measures aiming to preserve oral health in post-COVID-19 era.

Conditions

COVID-19; Periodontitis

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Late COVID-19 and PERIO

Participants in the late convalescent stage of COVID-19 with diagnosed periodontitis

No interventions assigned to this group

PERIO non COVID-19

Participants with diagnosed periodontitis and no history of COVID-19

No interventions assigned to this group

Late COVID-19 non PERIO

Participants in the late convalescent stage of COVID-19 without periodontitis

No interventions assigned to this group

Non PERIO non COVID-19

Participants with no history of COVID-19 and without periodontitis

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• self-reported good general health, ≥ 14 erupted teeth excluding third molars. For periodontally healthy: Bleeding on probing score ≤10%, without attachment loss and radiographic bone loss and probing depth ≤ 3 mm in every site (Trombelli L et al., 2018). For periodontitis patients: periodontitis in stages II-IV.

Exclusion Criteria

• history of periodontal treatment in previous six months, acute oral infection, presence of systemic disease(s), pregnancy, lactation, smoking ≥ 10 cigarettes per day

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Belgrade

OTHER

Sponsor Role: lead

Responsible Party

Jelena Roganović

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

School of Dental Medicine University of Belgrade

Belgrade, , Serbia

Site Status: RECRUITING

Countries

Serbia

Central Contacts

Jelena Roganović, Professor

Role: CONTACT

jelena.roganovic@stomf.bg.ac.rs

+381641976330

Facility Contacts

Jelena Roganović, Professor

Role: primary

Other Identifiers

36/10

Identifier Type: -

Identifier Source: org_study_id