Predictive Models of Treatment Responses and Survival Outcomes in Patients With Osteosarcoma

NCT ID: NCT05194605

Last Updated: 2022-01-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-01

Study Completion Date

2024-12-31

Brief Summary

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The aim of this study was to developed and validated models to predict therapeutic responses and patients' survivals in patients with osteosarcoma and compared these models with currently available models.

Detailed Description

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The investigator performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict treatment responses and survival outcomes in patients with biopsy-proven osteosarcoma. Secondly, the investigator aimed to compare the predictive accuracy with currently available noninvasive model.

Conditions

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Osteosarcoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Retrospective cohort

The internal cohort was retrospectively enrolled in West China Hospital, Sichuan University from June 2010 and December 2020. It is a training and internal validation cohort.

Prediction model

Intervention Type OTHER

We develop and validate clinical models to predict treatment responses and survival outcomes in patients with biopsy-proven with osteosarcoma.

Prospective cohort

The same inclusion/exclusion criteria were applied for the same center prospectively. It is an external validation cohort.

Prediction model

Intervention Type OTHER

We develop and validate clinical models to predict treatment responses and survival outcomes in patients with biopsy-proven with osteosarcoma.

Interventions

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Prediction model

We develop and validate clinical models to predict treatment responses and survival outcomes in patients with biopsy-proven with osteosarcoma.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Receiving no treatment before diagnosis
* With written informed consent

Exclusion Criteria

* Clinical data missing
* Without written informed consent
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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West China Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yuhan Yang

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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West China Hospital, Sichuan University

Chengdu, Sichuan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yuhan Yang, MD

Role: CONTACT

Phone: 8613258389785

Email: [email protected]

Facility Contacts

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Yuhan Yang, MD

Role: primary

Other Identifiers

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HX-20211288

Identifier Type: -

Identifier Source: org_study_id