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Oncological and Functional Outcomes in Lower Limb Osteosarcoma Pediatric Patient

NCT ID: NCT06162962

Last Updated: 2023-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

345 participants

Study Classification

OBSERVATIONAL

Study Start Date

2000-01-01

Study Completion Date

2023-11-23

Brief Summary

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Retrospective analysis of specific characteristics of complications and long-term oncological and function outcomes in lower-limb osteosarcoma pediatric patients.

Detailed Description

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Clinical and functional outcomes were compared based on age groups, surgical methods, type of prosthesis, and primary tumor location. Patients were divided into the Low-age group (≤10 years old) and the High-age group (\>10 years old). Overall Survival rate (OS), Progression-Free Survival rate (PFS), and prosthesis survival rate were assessed using Kaplan-Meier curves, and non-parametric survival analysis (log-rank test) was used for comparison. The incidence of complications, local relapse rate (LRR), metastasis rate, final limb-salvage and amputation rate, and Musculoskeletal Tumor Society (MSTS) score of different independent groups were further evaluated using χ2 test or Fisher's exact test, and t-test was employed to evaluate the measurement data.

Conditions

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Osteosarcoma Pediatric Lower Limb Injury Outcome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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age groups

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Retrospective analysis

Intervention Type OTHER

Retrospective analysis

surgical methods

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Retrospective analysis

Intervention Type OTHER

Retrospective analysis

type of prosthesis

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Retrospective analysis

Intervention Type OTHER

Retrospective analysis

primary tumor location

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Retrospective analysis

Intervention Type OTHER

Retrospective analysis

Enneking stage

The general characteristic of patients and clinical data including age, Enneking stage, surgical methods, type of prosthesis, primary tumor location were recorded.

Retrospective analysis

Intervention Type OTHER

Retrospective analysis

Interventions

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Retrospective analysis

Retrospective analysis

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Diagnosed lower limb osteosarcoma patients under the age of 14;
2. Performing tumor resection treatment in our hospital;
3. There is complete clinical registration data available.

Exclusion Criteria

1. Not undergoing surgical treatment in our hospital;
2. Age older than 14 years old;
3. No available clinical registration data or lost follow-up patients;
4. Non lower limb osteosarcoma patients.
Minimum Eligible Age

4 Years

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Changye Zou

OTHER

Sponsor Role lead

Responsible Party

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Changye Zou

Clinical Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Changye Zou

Guangzhou, Guangdong, China

Site Status

Countries

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China

References

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Xu M, Tu J, Huang Y, Wang B, Zhao Z, Lin T, Huang G, Yin J, Xie X, Shen J, Zou C. Comparison of oncological and functional outcomes in Lower-limb osteosarcoma pediatric patients: a large single-center retrospective cohort study. Int J Surg. 2024 Jul 1;110(7):4208-4220. doi: 10.1097/JS9.0000000000001340.

Reference Type DERIVED
PMID: 38471042 (View on PubMed)

Other Identifiers

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Changye Zou

Identifier Type: -

Identifier Source: org_study_id