Evaluation of Next-Generation Sequencing-based Metabarcoding Versus Culturing for Microbiological Assessment in Infectious Keratitis
NCT ID: NCT05183906
Last Updated: 2024-02-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
100 participants
OBSERVATIONAL
2021-12-09
2024-06-01
Brief Summary
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Detailed Description
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Only patients with a corneal infiltrate of a minimum of 2 mm or of 1 mm within the central 6 mm of the cornea will be included in the study.
Sampling includes two samples from the contralateral healthy eye to control for the patient's normal microbiome, evaluated with culturing in broth and with NGS.
From the infiltrate, samples include culturing on Sabouraud agar, chocolate agar, and blood agar, culturing in broth medium, and samples for NGS.
A total of 100 patients will be included.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Next generation sequencing
Evaluation of microbiological culturing versus next generation sequencing for ribosomal DNA
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Aarhus University Hospital
OTHER
Responsible Party
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Anders Ivarsen
Consultant, Associate Professor
Locations
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Department of Ophthalmology, Aarhus University Hospital
Aarhus, , Denmark
Countries
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Facility Contacts
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Other Identifiers
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KeratitisMicrobiome
Identifier Type: -
Identifier Source: org_study_id
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