Evaluation of Central Corneal Thickness in Patients With Vernal Keratoconjunctivitis Using Topical Steroids

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

34 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-20

Study Completion Date

2026-02-20

Brief Summary

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This prospective observational cohort study aims to assess changes in central corneal thickness (CCT) in vernal keratoconjunctivitis (VKC) patients using topical steroids. Data will be collected from tertiary care hospitals such as Al-Mustafa eye hospital and Jinnah Hospital, Lahore.

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Detailed Description

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A total of 34 participants, including an adjustment for a 10% dropout rate, will be recruited using purposive sampling. The study will last six months. Eligible participants (aged 5-25 years) must have a confirmed VKC diagnosis and be on topical steroids, with exclusions for prior ocular surgery, systemic steroid use, and contact lens wear. Baseline assessments will include demographic data, VKC severity, and CCT measurements via pachymetry and optical coherence tomography. Follow-up evaluations at one and three months will track CCT changes. A paired t-test will compare baseline and follow-up measurements. This study will help understand the impact of topical steroids on CCT in VKC patients.

Conditions

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Vernal Keratoconjunctivitis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Young adults aged between 5-25 years
* Confirmed diagnosis of VKC
* Currently prescribe topical steroid e.g, dexamethasone, prednisolone
* No prior history of corneal surgery or trauma
* Willing to attend follow-up visits and comply with the treatment protocol.

Exclusion Criteria

* History of ocular surgery or trauma
* Presence of other corneal pathologies (e.g., Keratoconus)
* Systemic immunosuppressant use or history of systemic steroid use in the past 06 months
* Use of other medications that could influence corneal thickness e.g, antiglaucoma drugs
* Contact lens use within 1 month prior to the study
* Severe dry eye or another ocular surface disease"

Minimum Eligible Age

5 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No