Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

NCT ID: NCT05181696

Last Updated: 2024-09-19

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2020-01-01
• Study Completion Date: 2025-05-31

Brief Summary

The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

Detailed Description

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. By analyzing X-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the Brixia system, during hospital admission, admission to the Respiratory Center, and during treatment at the Respiratory Center. All patients will have their Sequential Organ Failure Assessment (SOFA) and/or Acute Physiology and Chronic Health Evaluation (APACHE II) values calculated upon admission. Inflammatory parameters (c-reactive protein (CRP), procalcitonin (PCT), interleukine-6 (IL-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (BUN), arterial blood gases and ventilation parameters on admission to the hospital, admission to the ICU, and on several occasions during treatment in the ICU will be analysed. Also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.

Conditions

COVID-19 Pneumonia; Sepsis; SARS-CoV-2 Acute Respiratory Disease; Pneumonia; Multiorgan Failure

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

COVID-19 pneumonia patients

Patients treated at the University Hospital Osijek Respiratory Center with pneumonia caused by SARS-CoV-2

Chest X-ray

Intervention Type: DIAGNOSTIC_TEST

Retrospective analysis of chest x-rays of patients with COVID-19

Interventions

Chest X-ray

Retrospective analysis of chest x-rays of patients with COVID-19

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Pneumonia caused by SARS-CoV-2 virus
• Admission to the ICU COVID-19 unit

Exclusion Criteria

• Patients with lung tumors or history of lung resection

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Osijek University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Nenad Nešković, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital Osijek

Locations

University hospital Osijek

Osijek, , Croatia

Site Status: RECRUITING

Countries

Croatia

Central Contacts

Nenad Nešković, PhD

Role: CONTACT

nneskov@gmail.com

+395996787250

Ivana Haršanji Drenjančević, PhD

Role: CONTACT

ihdrenjan@gmail.com

+385915108941

Facility Contacts

Nenad Nešković, PhD

Role: primary

nneskov@gmail.com

+385996787250

References

Booth A, Reed AB, Ponzo S, Yassaee A, Aral M, Plans D, Labrique A, Mohan D. Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis. PLoS One. 2021 Mar 4;16(3):e0247461. doi: 10.1371/journal.pone.0247461. eCollection 2021.

Reference Type: BACKGROUND

PMID: 33661992 (View on PubMed)

Wolff D, Nee S, Hickey NS, Marschollek M. Risk factors for Covid-19 severity and fatality: a structured literature review. Infection. 2021 Feb;49(1):15-28. doi: 10.1007/s15010-020-01509-1. Epub 2020 Aug 28.

Reference Type: BACKGROUND

PMID: 32860214 (View on PubMed)

Mahat RK, Panda S, Rathore V, Swain S, Yadav L, Sah SP. The dynamics of inflammatory markers in coronavirus disease-2019 (COVID-19) patients: A systematic review and meta-analysis. Clin Epidemiol Glob Health. 2021 Jul-Sep;11:100727. doi: 10.1016/j.cegh.2021.100727. Epub 2021 Mar 20.

Reference Type: BACKGROUND

PMID: 33778183 (View on PubMed)

Borghesi A, Maroldi R. COVID-19 outbreak in Italy: experimental chest X-ray scoring system for quantifying and monitoring disease progression. Radiol Med. 2020 May;125(5):509-513. doi: 10.1007/s11547-020-01200-3. Epub 2020 May 1.

Reference Type: BACKGROUND

PMID: 32358689 (View on PubMed)

Borghesi A, Zigliani A, Masciullo R, Golemi S, Maculotti P, Farina D, Maroldi R. Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients. Radiol Med. 2020 May;125(5):461-464. doi: 10.1007/s11547-020-01202-1. Epub 2020 May 1.

Reference Type: BACKGROUND

PMID: 32358691 (View on PubMed)

Other Identifiers

OsijekUH-RC

Identifier Type: -

Identifier Source: org_study_id