Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2022-05-09
2027-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Control group
Healthy control group
Metabolic testing
Participants will complete a metabolic testing protocol that includes intravenous infusion of stable isotope labeled tracers and blood sampling to determine lipoprotein kinetics
T1D group
T1D group
Metabolic testing
Participants will complete a metabolic testing protocol that includes intravenous infusion of stable isotope labeled tracers and blood sampling to determine lipoprotein kinetics
Interventions
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Metabolic testing
Participants will complete a metabolic testing protocol that includes intravenous infusion of stable isotope labeled tracers and blood sampling to determine lipoprotein kinetics
Eligibility Criteria
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Inclusion Criteria
* premenopausal/eumenorrheic and not pregnant or breastfeeding
* non-obese (body mass index ≥18.5\<30.0 kg/m2)
* Fasting plasma triglyceride \<150 mg/dL
* Fasting plasma glucose \<100 mg/dL
* Plasma glucose 2 h after a 75 g oral glucose challenge \<140 mg/dL
* HbA1c \<5.6%.
* stable insulin regimen (multiple daily insulin injections or continuous subcutaneous insulin) for at least 8 weeks before screening
* no use of diabetes medications other than insulin
* HbA1c \<8.0%, basal (overnight fasted)
* no severe symptomatic hypoglycemic event associated with a seizure or requiring help from other people or a medical facility in the 6 months prior to screening or metabolic testing
Exclusion Criteria
* use of tobacco products, excessive amounts of alcohol, or dietary supplements and/or medications known to affect lipid metabolism
* hypothyroidism or other disorders known to affect lipid metabolism
* conditions that would make it impossible to complete the study protocol
18 Years
45 Years
ALL
Yes
Sponsors
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University of Washington
OTHER
University of Missouri-Columbia
OTHER
Responsible Party
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Bettina Mittendorfer
Senior Associate Dean for Research
Principal Investigators
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Bettina Mittendorfer
Role: PRINCIPAL_INVESTIGATOR
University of Missouri-Columbia
Locations
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University of Missouri School of Medicine
Columbia, Missouri, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2097324
Identifier Type: -
Identifier Source: org_study_id
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