Inhaled IAV vs Inhaled Eucalyptus for the Treatment of Nausea With Acute Migraine

NCT ID: NCT05175521

Last Updated: 2025-10-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-11

Study Completion Date

2026-01-31

Brief Summary

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The goal of this study is to compare the efficacy and adverse events of inhaled isopropyl alcohol vapor (IAV) versus placebo (inhaled eucalyptus scent (IES) (1:20 dilution in mineral oil) for treating nausea associated with acute migraine attacks.

Detailed Description

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The main goal of this study is to examine the efficacy of (nausea reduction and time to use of other anti-nausea medications) and side effects of inhaled isopropyl alcohol vapor (IAV) for treating nausea among migraine patients using a double blind randomized control methodology. IAV is being compared inhaled eucalyptus scent (IES) (1:20 dilution in mineral oil) which has not shown benefit for treating nausea or migraine and is therefore considered placebo in this study.

Conditions

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Migraine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Eucalyptus Oil Scent

Eucalyptus oil diluted in mineral oil 1:20

Group Type PLACEBO_COMPARATOR

Eucalyptus Oil Scent

Intervention Type OTHER

Eucalyptus oil in mineral (1:20) will be inhaled at least 30 minutes after onset of nausea associated with a migraine attack

Isopropyl Alcohol Vapors

Isopropyl Alcohol 70%

Group Type ACTIVE_COMPARATOR

Isopropyl Alcohol Vapors

Intervention Type OTHER

Isopropyl Alcohol 70% will be inhaled at least 30 minutes after onset of nausea associated with a migraine attack

Interventions

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Eucalyptus Oil Scent

Eucalyptus oil in mineral (1:20) will be inhaled at least 30 minutes after onset of nausea associated with a migraine attack

Intervention Type OTHER

Isopropyl Alcohol Vapors

Isopropyl Alcohol 70% will be inhaled at least 30 minutes after onset of nausea associated with a migraine attack

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients 18 to 65 years old with nausea associated migraines at least twice per month

Exclusion Criteria

* Patients \<18 or \>65 years old
* Patients without a diagnosis of acute migraine
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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HonorHealth Research Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jill Rau, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

HonorHealth Research Institute

Locations

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HonorHealth Bob Bové Neuroscience Institute

Scottsdale, Arizona, United States

Site Status

Countries

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United States

Other Identifiers

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1718502

Identifier Type: -

Identifier Source: org_study_id

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