Epigenetic Regulation of Exercise Induced Asthma

NCT ID: NCT05174689

Last Updated: 2022-01-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-01

Study Completion Date

2022-09-30

Brief Summary

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The purpose of this study is to investigate the micro ribonucleic acid (mRNA) profiles of patients with EIA without allergic sensitization and EIA with house dust mite sensitization compared to that of healthy controls.

Detailed Description

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Patients with known EIA are periodically reexamined by medical history, clinical examination, bodyplethysmography, spirometry, exhaled nitric oxide (eNO), skin prick test, methacholin challenge test and exercise-challenge in a cold-chamber at 2-4°C (ECC). Additionally the investigators gathers the questionnaires: Asthma Control Test (ACT) and Dyspnoe Index (DI).

Besides these standard procedures the investigators want to investigate the micro-RNA profiles in two EIA subgroups: EIA with house-dust allergy (n = 24) and EIA without house-dust allergy (n = 24).

Both groups are characterized by different eNO levels. The patients with EIA and house-dust allergy should have an eNO \> 30 ppb, the patients with EIA without house-dust allergy an eNO \< 20 ppb.

The micro-RNA profiles of the both EIA subgroups will be compared the micro RNA profiles of 20 healthy controls .

Therefore blood will be taken (for a complete blood count and micro RNA analysis) at three points of time: before ECC, directly after ECC and after 24 hours ± 4 hours after ECC.

Conditions

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Exercise Induced Asthma House Dust Mite Allergy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

The micro RNA profile of patients with known EIA and house dust mite allergy and patients with EIA without allergic sensitization are compared to the micro RNA profile of healthy controls
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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EIA wih house dust mite

Patients with EIA and house-dust mite allergy and an eNO \> 30 ppb

Group Type OTHER

Exercise challenge in the cold chamber (ECC)

Intervention Type DIAGNOSTIC_TEST

Exercise challenge (defined as running on a treadmill for 6-8 minutes on submaximal work load in a cold chamber. Gradient: 10%, temperature 2-4°C. After the exercise challenge controlling bodyplethysmography and spirometry after 5, 10, 15 and 30 minutes. A positive reaction is a decrease of ≥ 10% of FEV1 in comparison to the initial value.

mRNA profile

Intervention Type DIAGNOSTIC_TEST

Blood taking with full blood exam and PAXgene tube for investigation oft the micro RNA profiles. The PAXgene Blood RNA kit insulates total RNA inclusive miRNA and small RNA which are centrifugated, pelletised, washed and incubated to detach proteins. For mapping the particular miRNA there will be generated libraries with specifical codes to match the analysis to the original probe. Next generation sequencing will be performed by MISeq REagent Kit v3 and the analysis oft the different expressions in the R Version 3.2.3. The divergent expressions will be refurbished by computer and databased.

standard diagnostic

Intervention Type DIAGNOSTIC_TEST

bodyplethysmography, spirometry, exhaled NO, skin prick test, asthma control test (ACT)

EIA without sensitization

Patients with EIA without allergic sensitization and an eNO \< 20 ppb

Group Type OTHER

Exercise challenge in the cold chamber (ECC)

Intervention Type DIAGNOSTIC_TEST

Exercise challenge (defined as running on a treadmill for 6-8 minutes on submaximal work load in a cold chamber. Gradient: 10%, temperature 2-4°C. After the exercise challenge controlling bodyplethysmography and spirometry after 5, 10, 15 and 30 minutes. A positive reaction is a decrease of ≥ 10% of FEV1 in comparison to the initial value.

mRNA profile

Intervention Type DIAGNOSTIC_TEST

Blood taking with full blood exam and PAXgene tube for investigation oft the micro RNA profiles. The PAXgene Blood RNA kit insulates total RNA inclusive miRNA and small RNA which are centrifugated, pelletised, washed and incubated to detach proteins. For mapping the particular miRNA there will be generated libraries with specifical codes to match the analysis to the original probe. Next generation sequencing will be performed by MISeq REagent Kit v3 and the analysis oft the different expressions in the R Version 3.2.3. The divergent expressions will be refurbished by computer and databased.

standard diagnostic

Intervention Type DIAGNOSTIC_TEST

bodyplethysmography, spirometry, exhaled NO, skin prick test, asthma control test (ACT)

Healthy controls

Healthy controls without allergic sensitization or known asthma

Group Type OTHER

mRNA profile

Intervention Type DIAGNOSTIC_TEST

Blood taking with full blood exam and PAXgene tube for investigation oft the micro RNA profiles. The PAXgene Blood RNA kit insulates total RNA inclusive miRNA and small RNA which are centrifugated, pelletised, washed and incubated to detach proteins. For mapping the particular miRNA there will be generated libraries with specifical codes to match the analysis to the original probe. Next generation sequencing will be performed by MISeq REagent Kit v3 and the analysis oft the different expressions in the R Version 3.2.3. The divergent expressions will be refurbished by computer and databased.

standard diagnostic

Intervention Type DIAGNOSTIC_TEST

bodyplethysmography, spirometry, exhaled NO, skin prick test, asthma control test (ACT)

Interventions

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Exercise challenge in the cold chamber (ECC)

Exercise challenge (defined as running on a treadmill for 6-8 minutes on submaximal work load in a cold chamber. Gradient: 10%, temperature 2-4°C. After the exercise challenge controlling bodyplethysmography and spirometry after 5, 10, 15 and 30 minutes. A positive reaction is a decrease of ≥ 10% of FEV1 in comparison to the initial value.

Intervention Type DIAGNOSTIC_TEST

mRNA profile

Blood taking with full blood exam and PAXgene tube for investigation oft the micro RNA profiles. The PAXgene Blood RNA kit insulates total RNA inclusive miRNA and small RNA which are centrifugated, pelletised, washed and incubated to detach proteins. For mapping the particular miRNA there will be generated libraries with specifical codes to match the analysis to the original probe. Next generation sequencing will be performed by MISeq REagent Kit v3 and the analysis oft the different expressions in the R Version 3.2.3. The divergent expressions will be refurbished by computer and databased.

Intervention Type DIAGNOSTIC_TEST

standard diagnostic

bodyplethysmography, spirometry, exhaled NO, skin prick test, asthma control test (ACT)

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* written agreement
* age \>=12 and \<= 24
* known exercise induced asthma
* Group 1: skin prick test positiv house-dust allergy, eNO \> 30 ppb, MCT PD20 \< 0,1 mg
* Group 2: skin prick test negative house-dust allergy, eNO \< 20 ppb, MCT PD20 \< 1 mg
* lung function before ECC forced vital capacity (FVC) ≥ 75% and forced exspiratory pressure in one second (FEV1) ≥ 70%


* written agreement
* age \>=18 and \<= 24

Exclusion Criteria

* age \< 12 und \> 24 years
* lung function FVC \< 75% und FEV1\< 70%
* inability to understand the range of the study
* chronic asthma with systemic cortisone therapy
* regular therapy with inhalative corticosteroids or leukotriene-antagonists \<14 days before visit 1
* intake of long acting beta-agonists (LABA) 48 h before examination
* intake of short acting beta-agonists (SABA) 8 h before examination
* acute severe infection (pneumonia) within the last 4 weeks
* other chronic diseases or infections (HIV, Tbc)
* pregnancy

For healthy controls


* age \< 18 and \> 24 years
* known asthma bronchiale or other chronic lung diseases
* lung function FVC \< 90% and FEV1 \< 80%
* allergic sensitization in skin prick test
* eNO \> 30 ppb
* inability to understand the range of the study
* acute severe infection (pneumonia) within the last 4 weeks
* other chronic diseases or infections (HIV, Tbc)
* pregnancy
Minimum Eligible Age

12 Years

Maximum Eligible Age

24 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Johann Wolfgang Goethe University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Stefan Zielen

Prof. Dr. med.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Melanie Dreßler, MD

Role: PRINCIPAL_INVESTIGATOR

Johann Wolfgang Goethe University Hospital

Locations

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Universitätsklinikum Frankfurt

Frankfurt am Main, Hesse, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Melanie Dreßler, MD

Role: CONTACT

+49-69-6301-4588

Helena Donath, MD

Role: CONTACT

+49-69-6301-4588

Facility Contacts

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Melanie Dreßler, MD

Role: primary

+49-69-6301-4588

Helena Donath, MD

Role: backup

+49-69-6301-4588

References

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Other Identifiers

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E68/21

Identifier Type: -

Identifier Source: org_study_id

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