RibFix Blu Thoracic Fixation System Versus Non-surgical Treatment in Non-flail Chest Rib Fractures

NCT ID: NCT05146986

Last Updated: 2024-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

167 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-02

Study Completion Date

2026-12-30

Brief Summary

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This is a prospective, multi-center, observational, cohort study involving skilled cardiothoracic surgeons who are experienced in implanting the treatment of non-flail chest rib fractures and the use of RibFix Blu Thoracic Fixation System.

Detailed Description

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The objective of this study is to evaluate the benefits of surgical stabilization of rib fractures (SSRF) in patients with non-flail chest rib fractures using RibFix Blu Thoracic Fixation System when compared to non-surgical (analgesia and symptomatic management) treatment. The study will include up to 167 cases of non-flail chest rib fractures with 95 cases in non-surgical treatment group and 72 cases in the surgical group. Each center may enroll up to maximum 30 cases to permit the assessment of outcome across a variety investigators and clinical settings. Enrolment will be competitive among sites and closed as soon as a total of 167 cases are recruited.

Conditions

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Rib; Fracture

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Non-surgical group

Patients will receive analgesia and symptomatic management treatment

Non surgical and Surgical

Intervention Type DEVICE

For non-surgical group, patients will receive non-surgical treatment (analgesia and symptomatic management treatment).

For surgical group, patients will receive surgical treatment using RibFix Blu Thoracic Fixation System.

Surgical group

Patients will receive surgical treatment using RibFix Blu Thoracic Fixation System

Non surgical and Surgical

Intervention Type DEVICE

For non-surgical group, patients will receive non-surgical treatment (analgesia and symptomatic management treatment).

For surgical group, patients will receive surgical treatment using RibFix Blu Thoracic Fixation System.

Interventions

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Non surgical and Surgical

For non-surgical group, patients will receive non-surgical treatment (analgesia and symptomatic management treatment).

For surgical group, patients will receive surgical treatment using RibFix Blu Thoracic Fixation System.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Age 18 and above (inclusive)
* Simple rib fracture with ≥ 3 consecutive ribs, and the broken ends showed clear displacements
* Indicated for surgical repair of rib fractures using RibFix Blu Thoracic Fixation System or non-surgical treatment (analgesia and symptomatic management treatment)
* Willing and able to complete scheduled follow-up evaluations as described in the study protocol
* Has participated in the Informed Consent process and is willing and able to sign an Institutional Review Board or Ethics Committee (IRB/EC) approved Patient Information/ Informed consent Form (PICF)

Exclusion Criteria

* Flail chest rib fractures based on radiological or clinical findings
* Previous rib fractures or pulmonary problems, requiring continuous oxygen use at home pre-trauma
* Presence of any serious medical issues that placed patient in generally poor conditions such that he or she could not tolerate the surgery
* Chest trauma associated with severe craniocerebral injury, abdominal organ injury, severe spinal injury, limb fracture, or pelvic fracture requiring long-term bed rest
* Has serious medical disease that is a contraindication for general anesthesia, such as cerebral infarction, myocardial infarction and hemorrhagic syndrome
* Any contraindications listed in the manufacturer's Instruction to use for RibFix Blu Thoracic Fixation System as per below:

* Spanning a midline sternotomy
* Active Infection
* Foreign body sensitivity
* Is known to be pregnant
* Is a prisoner, known alcohol or drug user or mentally incompetent or unable to understand what participation in this study entails.
* Participation in another surgical intervention that may influence any of the outcome parameters.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Zimmer Biomet

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Silvana Marasco, Professor

Role: PRINCIPAL_INVESTIGATOR

The Alfred

Locations

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Hunter New England Health District

Sydney, New South Wales, Australia

Site Status NOT_YET_RECRUITING

Flinders Medical Centre

Bedford Park, South Australia, Australia

Site Status RECRUITING

The Alfred (Alfred Health)

Melbourne, Victoria, Australia

Site Status RECRUITING

Yonsei Wonju Severance Christian Hospital

Wŏnju, Gangwon-do, South Korea

Site Status RECRUITING

Ajou University Hospital

Suwon, Gyeonggi-do, South Korea

Site Status RECRUITING

Countries

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Australia South Korea

Central Contacts

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Irene Chong

Role: CONTACT

Facility Contacts

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Zsolt Janos Balogh

Role: primary

Gregory David Rice, MD

Role: primary

Silvana Marasco, Professor

Role: primary

Chun

Role: primary

Jong Hwan Moon

Role: primary

Other Identifiers

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CSA2021-16SU

Identifier Type: -

Identifier Source: org_study_id

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