Efficacy of Er: YSGG Laser in Treatment of Peri-implantitis
NCT ID: NCT05137821
Last Updated: 2023-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
3 participants
INTERVENTIONAL
2023-08-10
2023-11-15
Brief Summary
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To assess the morphological changes and the biological response (biocompatibility) of implant surface after Er: YSGG laser therapy through Profilometer analysis and cell culture process to detect attachment, differentiation, and mineralization of Isolated rat Bone Marrow Mesenchymal stem cells (rBMMSCs) respectively as secondary objectives.
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Detailed Description
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To assess the morphological changes and the biological response (biocompatibility) of implant surface after Er: YSGG laser therapy through Profilometer analysis and cell culture process to detect attachment, differentiation, and mineralization of Isolated rat Bone Marrow Mesenchymal stem cells (rBMMSCs) respectively as secondary objectives.
The study was designed as an Ex Vivo study. Four periodontally and systemically healthy volunteers of both gender are included in this study for the formation of in vivo plaque biofilm. Each volunteer will wear a hard resin splint carrying six rough (machined implant; 3.3mm diameter, 8mm length) for 4 days to accumulate dental plaque naturally on the titanium surfaces of the implants.
Therefore, 24 implants will be assessed for Er: YSGG laser therapy in different bone defect simulators.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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non tested comparative group
two sealed new implants as a control
no therapy
new sealed implant without any surface treatment
Er: YSGG laser tested group
24 infected implants divided into four subgroups that will be decontaminated by Er: YSGG laser in various peri-implant defects
Er: YSGG laser
Er: YSGG laser decontamination of infected implant surfaces to simulate peri-implantitis therapy
Interventions
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Er: YSGG laser
Er: YSGG laser decontamination of infected implant surfaces to simulate peri-implantitis therapy
no therapy
new sealed implant without any surface treatment
Eligibility Criteria
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Inclusion Criteria
* Age: 25 - 55 years.
* Medically controlled according to medical coding of review of systems (ROS)
Exclusion Criteria
* Participants with ill-fitting restorations in both upper first molars that affect the stability of the stent.
* Participants not following oral hygiene instructions.
* Participants on dental treatment during the study period.
* Participants with a history of drug administration
* Vulnerable group.
* Participants with long-term mouthwash administration.
25 Years
55 Years
ALL
Yes
Sponsors
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Ain Shams University
OTHER
Responsible Party
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alaa
Assistant lecturer of oral medicine and periodontology
Locations
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Ain Shams Dental School
Cairo, , Egypt
Countries
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References
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Hashim A, Kheir El Din NH, El-Khazragy N, Almalahy HG. Comparison of the efficacy of Er,Cr:YSGG laser on oral biofilm removal from implant surfaces with various application times for the treatment of peri-implantitis defects: ex vivo study. BMC Oral Health. 2024 Aug 22;24(1):980. doi: 10.1186/s12903-024-04698-5.
Other Identifiers
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FDASU-REC ID210314
Identifier Type: -
Identifier Source: org_study_id
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