Optimization of Spleen VCTE Examinations with FibroScan

NCT ID: NCT05122416

Last Updated: 2025-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

433 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-06-01

Study Completion Date

2024-11-22

Brief Summary

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This is an European, prospective, interventional, and multicenter clinical investigation which main objective is to develop a spleen examination dedicated to overweight or obese patients and assess its applicability. It will take place in 4 sites (1 site in the Netherlands, 2 sites in Spain and 1 site in Romania) to include a total of 500 patients (adults and children).

Detailed Description

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Conditions

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Spleen; Fibrosis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

There will be 6 different groups of patients depending on the spleen to skin distance and the presence or absence of splenomegaly. Every patient in every group will do an ultrasound and 2 FibroScan exams. The differences between Group 1 (1a and 1b), Group 2 (2a and 2b) and Group 3 (3a and 3b) are the probes that will be used to do the FibroScan.
Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Group 1a: SSD<15mm and with splenomegaly

Patients with a Spleen to Skin Distance less than 15mm and who present a splenomegaly.

Group Type EXPERIMENTAL

FibroScan examination (S)

Intervention Type DEVICE

A FibroScan examination with the Exploratory S probe.

FibroScan examination (Standard M)

Intervention Type DEVICE

A FibroScan examination with the Standard M probe.

Group 1b: SSD<15mm and without splenomegaly

Patients with a Spleen to Skin Distance less than 15mm and who does not present a splenomegaly.

Group Type EXPERIMENTAL

FibroScan examination (S)

Intervention Type DEVICE

A FibroScan examination with the Exploratory S probe.

FibroScan examination (Standard M)

Intervention Type DEVICE

A FibroScan examination with the Standard M probe.

Group 2a : 15<SSD<25mm and with splenomegaly

Patients with a Spleen to Skin Distance between 15 and 25 mm and who present a splenomegaly.

Group Type EXPERIMENTAL

FibroScan examination (M)

Intervention Type DEVICE

A FibroScan examination with the Optimized M probe.

FibroScan examination (Standard M)

Intervention Type DEVICE

A FibroScan examination with the Standard M probe.

Group 2b : 15<SSD<25mm and without splenomegaly

Patients with a Spleen to Skin Distance between 15 and 25 mm and who does not present a splenomegaly.

Group Type EXPERIMENTAL

FibroScan examination (M)

Intervention Type DEVICE

A FibroScan examination with the Optimized M probe.

FibroScan examination (Standard M)

Intervention Type DEVICE

A FibroScan examination with the Standard M probe.

Group 3.1.a: SSD≥25mm and with splenomegaly

Patients with a Spleen to Skin Distance higher than 25 mm and who present a splenomegaly.

Group Type EXPERIMENTAL

FibroScan examination (XL)

Intervention Type DEVICE

A FibroScan examination with the Exploratory XL probe.

FibroScan examination (Standard M)

Intervention Type DEVICE

A FibroScan examination with the Standard M probe.

Group 3.1.b: SSD≥25mm and without splenomegaly

Patients with a Spleen to Skin Distance higher than 25 mm and who does not present a splenomegaly.

Group Type EXPERIMENTAL

FibroScan examination (XL)

Intervention Type DEVICE

A FibroScan examination with the Exploratory XL probe.

FibroScan examination (Standard M)

Intervention Type DEVICE

A FibroScan examination with the Standard M probe.

3.2 Patient with BMI >or = to 35kg/m²

Patients with a Spleen to Skin Distance higher than 25 mm and BMI \> or = to 35kg/m².

Group Type EXPERIMENTAL

FibroScan examination (M)

Intervention Type DEVICE

A FibroScan examination with the Optimized M probe.

FibroScan examination (XL)

Intervention Type DEVICE

A FibroScan examination with the Exploratory XL probe.

FibroScan examination (Standard M)

Intervention Type DEVICE

A FibroScan examination with the Standard M probe.

Interventions

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FibroScan examination (S)

A FibroScan examination with the Exploratory S probe.

Intervention Type DEVICE

FibroScan examination (M)

A FibroScan examination with the Optimized M probe.

Intervention Type DEVICE

FibroScan examination (XL)

A FibroScan examination with the Exploratory XL probe.

Intervention Type DEVICE

FibroScan examination (Standard M)

A FibroScan examination with the Standard M probe.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Adult or pediatric patient able to give written informed consent (parents/legal tutors in case of minor patients),
2. Patient affiliated to the healthcare system
3. Adult or children patient followed for a liver disease a suspicion of liver disease or for a consequence of a liver disease, with or without splenomegaly and having a spleen to skin distance (SSD) measurement performed during the screening ultrasound exam.

Exclusion Criteria

1. Vulnerable patient- other than pediatric patients
2. Patients with ascites
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Echosens

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert de Knegt, PhD

Role: PRINCIPAL_INVESTIGATOR

University Medical Center Rotterdam

Locations

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University Medical Center Rotterdam

Rotterdam, , Netherlands

Site Status

Regional Institute of Gastroenterology and Hepatology "Octavian Fodor" (IRGH)

Cluj-Napoca, , Romania

Site Status

Hospital Puerta de Hierro Majadahonda

Madrid, , Spain

Site Status

Hospital Universitario La Paz

Madrid, , Spain

Site Status

Countries

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Netherlands Romania Spain

Other Identifiers

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M139

Identifier Type: -

Identifier Source: org_study_id

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