NAFLD Study: US vs Liver Biopsy

NCT ID: NCT04101162

Last Updated: 2020-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-15

Study Completion Date

2020-12-15

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Evaluate the diagnostic accuracy of the new ultrasound software vs hepatic histology, the current reference standard for the diagnosis of NAFLD and NASH in 20 obese patients (BMI\> 30) candidates for laparoscopic bariatric surgery and / or cholecystectomy

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Non-Alcoholic Fatty Liver Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

liver biopsy

Group Type OTHER

shear waves elastography; liver biopsy

Intervention Type DIAGNOSTIC_TEST

Diagnostic accuracy in a new ultrasound software compared to histology for Non Alcoholic Fatty liver disease (NAFLD) and Non Alcoholic Steato Hepatitis (NASH)

ATI

Group Type OTHER

shear waves elastography; liver biopsy

Intervention Type DIAGNOSTIC_TEST

Diagnostic accuracy in a new ultrasound software compared to histology for Non Alcoholic Fatty liver disease (NAFLD) and Non Alcoholic Steato Hepatitis (NASH)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

shear waves elastography; liver biopsy

Diagnostic accuracy in a new ultrasound software compared to histology for Non Alcoholic Fatty liver disease (NAFLD) and Non Alcoholic Steato Hepatitis (NASH)

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patients who are candidates for bariatric surgery between the ages of 18 and 65,

* BMI\> 40 kg / m2, in the absence of any other comorbidity
* BMI\> 35 kg / m2, in the presence of comorbidities among those classically considered to be associated with obesity
* ICM\> 30 kg / m2, in the presence of T2DM not in glycometabolic compensation
2. Patients who are candidates for laparoscopic cholecystectomy for symptomatic calculi with BMI\> 30

Exclusion Criteria

* Age ≤ 18 or ≥ 65
* Any concurrent surgical procedure except cholecystectomy and hiatal hernia repair
* Conversion into laparotomy surgery
* Post-operative complications requiring new surgical treatment
* Patient not compliant in the follow-up
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Roma La Sapienza

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Gianfranco Silecchia

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

ICOT Latina

Latina, LT, Italy

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Italy

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

ANNA GUIDA, medicine

Role: CONTACT

+393288699401

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Gianfranco Silecchia, medicine

Role: primary

+3907736511

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

0109926/2018

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Fibrosis Reduction in Non Alcoholic Steatohepatitis
NCT05798702 ACTIVE_NOT_RECRUITING NA