Denosumab vs Zoledronic Acid and Osteoporotic Compression Fracture
NCT ID: NCT05106517
Last Updated: 2023-02-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
PHASE2/PHASE3
122 participants
INTERVENTIONAL
2021-09-08
2023-03-11
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Denosumab and Screw Fixation for Osteoporotic Compression Fracture
NCT05065164
Denosumab vs Zoledronate After Vertebroplasty
NCT05598606
Denosumab vs Alendronate After Vertebroplasty
NCT05662358
Denosumab and Osteoporotic Vertebral Compression Fracture
NCT05058443
A Study to Compare Denosumab With Zoledronic Acid in Subjects With Bone Metastases From Solid Tumors
NCT01920568
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
denosumab
Denosumab 60mg/6 months subcutaneously + placebo intravenous
Denosumab
Denosumab 60mg/6 months subcutaneously + placebo iv
zoledronic acid
intravenous zoledronic acid and placebo /6 months subcutaneously
Zoledronic acid
Iv zoledronic acid and placebo /6 months subcutaneously
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Denosumab
Denosumab 60mg/6 months subcutaneously + placebo iv
Zoledronic acid
Iv zoledronic acid and placebo /6 months subcutaneously
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* X-ray diagnosis of 1-2 vertebral compression fractures
* Dual eneragy X ray test for bone mineral density T value less than -1
* fracture history lasted within 6 weeks
* Must be MRI showed bone marrow edema of injured segment
* Must be lower back pain, local spines tenderness
Exclusion Criteria
* Must be able to have no patients with intervertebral fissure
* Must be able to have no infection
* Must be able to have no malignancy
* Must be able to have no neurological dysfunction
* Must be able to have no calcium level ≤2.13 mmol/L
* Must be able to have no previous use of anti-osteoporosis drugs
* Must be able to have no inability to perform magnetic resonance imaging
* Must be able to have no prior back surgery
* Must be able to have no other established contraindications for elective surgery
40 Years
90 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Shenzhen People's Hospital
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
ShenzhenPH
Shenzhen, Guangdong, China
Countries
Review the countries where the study has at least one active or historical site.
Central Contacts
Reach out to these primary contacts for questions about participation or study logistics.
Facility Contacts
Find local site contact details for specific facilities participating in the trial.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
ShenzhenPH spine wang04
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.