Observational Prospective Study.at the End of the Study the Patients Will be Classified According to PH,Serum Bicarbonate and Serum Sodium Into 6 Groups and Statistical Analysis Will be Performed Using Spss

NCT ID: NCT05082064

Last Updated: 2023-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

121 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-10-08

Study Completion Date

2023-01-07

Brief Summary

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1-to identify the prognostic value of serum bicarbonate and serum electrolytes at time of admission and their association with development of complications ,length of hospital stay ,prognosis and mortality in hospitalized cirrhotic patient

Detailed Description

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the purpose of this study will be explore the impact of data obtained for the arterial blood gas parameters and serum bicarbonate and electrolytes at the time of hospital admission on adverse clinical outcomes ,duration of length of hospital stay and mortality in patients with cirrhosis .Furthermore incorporation these parameters into model of end stage liver disease could help to improve the prognostic value of MELDscore in comparison to the prognostic value of traditional equation of original MELD and child score

Conditions

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Liver Cirrhosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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MELD score group A

MELD score :group A\<25

arterial blood gases and serum electrolytes

Intervention Type DIAGNOSTIC_TEST

arterial bloog gases parameters serum potassium serum sodium serum calcium

MELD group B

Group B\>25

arterial blood gases and serum electrolytes

Intervention Type DIAGNOSTIC_TEST

arterial bloog gases parameters serum potassium serum sodium serum calcium

MELD-PACO2 Group C

Group C\<25

arterial blood gases and serum electrolytes

Intervention Type DIAGNOSTIC_TEST

arterial bloog gases parameters serum potassium serum sodium serum calcium

MELD -PACO2 Group D

Group D\>25

arterial blood gases and serum electrolytes

Intervention Type DIAGNOSTIC_TEST

arterial bloog gases parameters serum potassium serum sodium serum calcium

MELD-BICARBONATE score Group E

Group E\<23

arterial blood gases and serum electrolytes

Intervention Type DIAGNOSTIC_TEST

arterial bloog gases parameters serum potassium serum sodium serum calcium

MELD-BICARBONATE Group F

Group F\>23

arterial blood gases and serum electrolytes

Intervention Type DIAGNOSTIC_TEST

arterial bloog gases parameters serum potassium serum sodium serum calcium

Interventions

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arterial blood gases and serum electrolytes

arterial bloog gases parameters serum potassium serum sodium serum calcium

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

patients with confirmed diagnosis of cirrhosis (age \>18 years ) who will be admitted to internal medicine department or will be admitted to intermediate care unit

* willing and agree to be included in the study

Exclusion Criteria

* patients without evidence of cirrhosis
* cirrhotic patients whom -younger than 18 years old

* have diabetic ketoacidosis
* with acute coronary syndrome
* with fulminant liver failure
* with heart failure
* with organ transplantation
* when arterial blood gases not be available
* patient refusal
* patient with HCC
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Heba Allah Fadel Abdel Rahman

doctor,principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Heba allah Fadel, Doctor

Role: PRINCIPAL_INVESTIGATOR

Clinical trial organization

Locations

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Heba Allah fadel abd elrahman

Sohag, , Egypt

Site Status

Countries

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Egypt

References

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Scheiner B, Lindner G, Reiberger T, Schneeweiss B, Trauner M, Zauner C, Funk GC. Acid-base disorders in liver disease. J Hepatol. 2017 Nov;67(5):1062-1073. doi: 10.1016/j.jhep.2017.06.023. Epub 2017 Jul 3.

Reference Type RESULT
PMID: 28684104 (View on PubMed)

Other Identifiers

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liver cirrhosis

Identifier Type: -

Identifier Source: org_study_id

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