Monofocal IOL Visual Outcomes When Targeting Mini Monovision

NCT ID: NCT05069415

Last Updated: 2024-02-13

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-04

Study Completion Date

2022-11-30

Brief Summary

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This study is a 3-month, prospective, up to 2 center, bilateral, randomized subject masked clinical evaluation of a monofocal intraocular lens (IOL) when both eyes are targeted for emmetropia and when the non-dominant eye is targeted for mini monovision (-0.75 D) in patients with or without astigmatism undergoing routine cataract surgery.

Detailed Description

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Conditions

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Cataract Presbyopia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

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Emmetropia

The target refraction for both eyes will be emmetropia (± 0.25 D).

Group Type ACTIVE_COMPARATOR

Eyhance IOL

Intervention Type DEVICE

Intraocular lens replaces the natural lens removed during cataract surgery in both eyes. Target emmetropia OU.

Eyhance IOL

Intervention Type DEVICE

Intraocular lens replaces the natural lens removed during cataract surgery in both eyes. Target mini monovision in the non-dominant eye.

Mini monovision

The target refraction for the dominant eye will be plano (± 0.25 D) and for the non-dominant eye between -0.75D ±0.15.

Group Type EXPERIMENTAL

Eyhance IOL

Intervention Type DEVICE

Intraocular lens replaces the natural lens removed during cataract surgery in both eyes. Target emmetropia OU.

Eyhance IOL

Intervention Type DEVICE

Intraocular lens replaces the natural lens removed during cataract surgery in both eyes. Target mini monovision in the non-dominant eye.

Interventions

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Eyhance IOL

Intraocular lens replaces the natural lens removed during cataract surgery in both eyes. Target emmetropia OU.

Intervention Type DEVICE

Eyhance IOL

Intraocular lens replaces the natural lens removed during cataract surgery in both eyes. Target mini monovision in the non-dominant eye.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject is undergoing bilateral cataract extraction with intraocular lens implantation.
* Willing and able to provide written informed consent for participation in the study
* Willing and able to comply with scheduled visits and other study procedures.
* Scheduled to undergo standard cataract surgery in both eyes within 6 - 30 days between surgeries.
* Subjects who require an IOL power in the range of +5.0 D to +34.0 D only.
* Potential postoperative visual acuity of 0.2 logMAR (20/32 Snellen) or better in both eyes.

Exclusion Criteria

* Severe preoperative ocular pathology: amblyopia, rubella cataract, proliferative diabetic retinopathy, shallow anterior chamber, macular edema, retinal detachment, aniridia or iris atrophy, uveitis, history of iritis, iris neovascularization, medically uncontrolled glaucoma, microphthalmos or macrophthalmos, optic nerve atrophy, macular degeneration (with anticipated best postoperative visual acuity less than 20/30), advanced glaucomatous damage, etc.
* Uncontrolled diabetes.
* Use of any systemic or topical drug known to interfere with visual performance.
* Contact lens use during the active treatment portion of the trial.
* Any concurrent infectious/non-infectious conjunctivitis, keratitis or uveitis.
* Clinically significant corneal dystrophy.
* Irregular astigmatism.
* History of chronic intraocular inflammation.
* History of retinal detachment.
* Pseudoexfoliation syndrome or any other condition that has the potential to weaken the zonules.
* Previous intraocular surgery.
* Previous refractive surgery.
* Previous keratoplasty
* Severe dry eye
* Pupil abnormalities
* Subject who may reasonably be expected to require a secondary surgical intervention at any time during the study (other than YAG capsulotomy, i.e. LASIK)
* Anesthesia other than topical anesthesia (i.e. retrobulbar, general, etc).
* Any clinically significant, serious or severe medical or psychiatric condition that may increase the risk associated with study participation or may interfere with the interpretation of study results.
* Participation in (or current participation) any ophthalmic investigational drug or ophthalmic device trial within the previous 30 days prior to the start date of this trial.
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Carolina Eyecare Physicians, LLC

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kerry D Solomon

Role: PRINCIPAL_INVESTIGATOR

Carolina Eyecare Physicians

Locations

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Center for Sight

Sarasota, Florida, United States

Site Status

Carolina Eyecare Physicians, LLC

Mt. Pleasant, South Carolina, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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CEP 21-001

Identifier Type: -

Identifier Source: org_study_id

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