Parkinson Progression Marker Initiative Online (PPMI Online)

NCT ID: NCT05065060

Last Updated: 2024-11-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-28

Study Completion Date

2041-12-31

Brief Summary

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Parkinson Progression Marker Initiative Online (PPMI Online) is an observational study collecting participant reported information from people with and without Parkinson's disease (PD), for the goal of better understanding risk and predictive factors for PD.

PPMI Online is part of the broader Parkinson Progression Marker Initiative aimed at identifying markers of disease progression for use in clinical trials of therapies to reduce progression of PD disability.

Detailed Description

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PPMI is a broad program that is expanding the goals of the original PPMI study, and will include this PPMI Online protocol, as well the PPMI Clinical \[NCT04477785\], PPMI Remote, PPMI Digital protocols (with external regulatory oversight). All participants in PPMI may be asked to participate in one or all of these protocols and their enrollment in these studies may occur in varying order. PPMI participants may also be asked to participate in additional PPMI companion studies (as they are developed), which may only involve a subset of PPMI participants based on their cohort designation

Conditions

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Parkinson Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Interventions

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Observation

Observation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Parkinson Disease (PD) Participants:

* Male or female age 18 years or older.
* Has received a diagnosis of Parkinson's disease

Participants without PD:

* Male or female age 18 years or older.
* Has not received a diagnosis of Parkinson's disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Michael J. Fox Foundation for Parkinson's Research

OTHER

Sponsor Role lead

Responsible Party

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Caroline M Tanner

Protocol Co- Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Caroline Tanner, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Kenneth L Marek, MD

Role: PRINCIPAL_INVESTIGATOR

Institute for Neurodegenerative Disorders

Locations

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UCSF Movement Disorders and Neuromodulation Center (MDNC)

San Francisco, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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University of California, San Francisco

Role: CONTACT

877-525-7764

Facility Contacts

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UCSF

Role: primary

877-525-7764

References

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Pierz KA, Aamodt W, Gochanour C, Kurth R, Brumm MC, Coffey CS, Heathers LE, Totten M, Doty RL, Marek K, Siderowf A; Parkinson's Progression Markers Initiative. Percentile scores for the revised University of Pennsylvania Smell Identification Test for 16,972 individuals 60 years of age and older. NPJ Parkinsons Dis. 2025 Oct 1;11(1):280. doi: 10.1038/s41531-025-01095-9.

Reference Type DERIVED
PMID: 41034300 (View on PubMed)

Other Identifiers

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PPMI-007

Identifier Type: -

Identifier Source: org_study_id

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