Cardiac MRI for Detection of Acute and Chronic Cardiac Involvement in Patients With Epilepsy
NCT ID: NCT05041296
Last Updated: 2021-09-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
200 participants
OBSERVATIONAL
2021-03-07
2024-12-31
Brief Summary
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1. In the acute setting, cardiac MRI will be performed in patients before and after a tonic-clonic seizure and compared intraindividually. In this study arm, potential acute seizure-induced myocardial damage will be detected.
2. In the chronic setting, cardiac MRI will be performed in patients with known chronic epilepsy during the seizure-free interval to detect potential chronic myocardial damage (myocardial fibrosis) and compared with a control population. Within the group of epilepsy patients, possible associations with various epilepsy-specific characteristics (e.g., form, cause, onset, duration, and severity of epilepsy) will be investigated.
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Chronic group
Chronic epilepsy with recurrent seizures
Cardiac magnetic resonance scan
Multiparametric cardiac magnetic resonance including traditional and quantitative functional and structural parameters
Acute group
Epilepsy and short-term history of seizures
Cardiac magnetic resonance scan
Multiparametric cardiac magnetic resonance including traditional and quantitative functional and structural parameters
Control group
Healthy participants
Cardiac magnetic resonance scan
Multiparametric cardiac magnetic resonance including traditional and quantitative functional and structural parameters
Interventions
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Cardiac magnetic resonance scan
Multiparametric cardiac magnetic resonance including traditional and quantitative functional and structural parameters
Eligibility Criteria
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Inclusion Criteria
2. examination under usual antiepileptic pharmacotherapy or medication up-dosing (if medication was reduced during video-EEG recording)
3. age between 18-60 years
Exclusion Criteria
2. pregnant and breastfeeding women
3. patients who use IUD for contraception
4. patients with a contraindication to contrast enhanced MRI
18 Years
60 Years
ALL
No
Sponsors
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University Hospital, Bonn
OTHER
Responsible Party
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Julian Alexander Luetkens
Principal Investigator, Senior Physician
Locations
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University Hospital Bonn, Clinic and Polyclinic for Epileptology
Bonn, North Rhine-Westphalia, Germany
University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology
Bonn, North Rhine-Westphalia, Germany
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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534/20
Identifier Type: -
Identifier Source: org_study_id
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