COAST Therapy in Advanced Solid Tumors and Prostate Cancer

NCT ID: NCT05036226

Last Updated: 2025-10-06

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 76 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-03-03
• Study Completion Date: 2027-05-21

Brief Summary

The purpose of this Phase I/II study is to determine the safety and effectiveness of up to 5 study drugs used together for the treatment of solid tumor cancers. The drugs are hydroxychloroquine, metformin, sirolimus, dasatinib and nelfinavir and are given orally.

Detailed Description

This is a Phase I/II safety and efficacy study of COAST therapy in patients with advanced cancer for which no satisfactory therapy options exist. An initial Phase I cohort of 18-30 patients with advanced cancer will receive increasing components of the COAST regimen following a traditional 3+3 escalation design. The starting COAST combination includes hydroxychloroquine, sirolimus and metformin (DL1 - base combination). If this three-drug base combination is cleared for safety, two dose levels will be opened for enrollment exploring the safety of the base in combination with either dasatinib or nelfinavir. Patients will be assigned sequentially to DL2A (base + dasatinib) and DL2B (base + nelfinavir). If nelfinavir is deemed unsafe in combination with the base (DL2B is not cleared for safety, regardless of the safety of DL2A), no further drug combinations will be explored since all remaining combinations include nelfinavir. If both dasatinib and nelfinavir are individually safe in combination with the base (DL2A and DL2B are both cleared for safety), two additional dose levels will be explored, the first combining all five drugs and the second exploring nelfinavir at a higher dose. If dasatinib is not safe but nelfinavir is safe in combination with the base (DL2A but not DL2B cleared for safety), then only one additional dose level will be explored combining the base with a higher dose of nelfinavir. If neither DL2A nor DL2B are cleared for safety, then only the base combination may be considered safe. Once a given dose level is cleared for initial DLT evaluation (e.g., 0 of 3 patients have a DLT or at most 1 of 6 have a DLT), additional patients may be enrolled (i.e., 'backfilled') to that dose level while a higher dose level is being evaluated for safety. Prioritization for backfill will be given to dose levels proximal to the current dose level being explored, and to those dose levels with evidence of anti-tumor activity. Backfill patients who are DLT-evaluable will be included in making decisions on dose escalation. Accrual to a dose-level may be halted and additional patients enrolled to a lower dose level that was previously cleared for safety depending on the total number of DLTs observed among all DLT-evaluable patients at that lower dose level (initial and backfill patients). The maximum tolerated mixture is the highest dose level at which at most 1 of 6 patients experiences a DLT or, for a dose level sample size >6 due to additional backfill patients, the highest dose level at which the observed DLT rate is ≤16.7%. The recommended phase 2 dose (RP2D) will be determined based on the totality of data, including the maximum tolerated mixture, dose adjustments, all safety data including any DLT-equivalent events (safety events that meet the criteria for a DLT regardless of treatment cycle and trial phase), and any response data. The study team may recommend a dose level lower than the maximum tolerated mixture as the RP2D based on their review of the data in aggregate. However, the RP2D will not exceed the dose level corresponding to the maximum tolerated mixture. The phase II efficacy trial will evaluate the anti-tumor activity of the COAST RP2D combination in patients with advanced prostate cancer based on a Simon two stage optimum design. The primary endpoint is the16-week PSA progression-free rate following treatment initiation, where PSA progression is defined per PCWG3. A maximum of 29 patients will be enrolled. In the first stage, 10 patients will be accrued. If none of the first 10 patients are PSA progression-free at 16 weeks, we will halt registration. If one or more patients are PSA progression-free at 16 weeks, an additional 19 patients will be enrolled. If 4 or more out of the 29 patients are PSA progression-free at 16 weeks, the treatment will be declared promising. This study is powered at 80% with a one-sided type I error rate of 5%. Specifically, this study has an 80% chance of declaring promise if the true 16-week PSA progression-free rate is at least 20%. If instead the true 16-week PSA progression-free rate is at most 5%, then the study has a 5% chance of declaring promise and a 60% chance of early termination. Phase I patients treated at the RP2D who meet inclusion and exclusion criteria for phase II will be included in the phase II cohort. Treatment will continue until there is 1) unacceptable toxicity (grade 3 or 4 toxicity that does not resolve to grade 1 or less by 28 days after drug withdrawal), 2) institution of new additional cancer therapy, 3) withdrawal of consent, 4) any condition that, in the opinion of the treating physician, renders continued COAST treatment to not be in the patient's best interest, 5) lack of compliance with study procedures by the patient, or 6) PSA progression by 16 weeks of COAST therapy.

Conditions

Prostate Cancer Recurrent; Solid Tumor, Adult

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Dose level 1

Group Type: EXPERIMENTAL

Hydroxychloroquine, Metformin, Sirolimus

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily

Dose level 2a

Group Type: EXPERIMENTAL

Hydroxychloroquine, Metformin, Sirolimus, Dasatanib

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Dasatinib 20mg daily

Dose level 2b

Group Type: EXPERIMENTAL

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 1250mg twice daily

Dose level 3a

Group Type: EXPERIMENTAL

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 1250mg twice daily Dasatanib 20mg daily

Dose level 3b

Group Type: EXPERIMENTAL

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 2500mg twice daily

Dose level 4

Group Type: EXPERIMENTAL

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 2500mg twice daily Dasatanib 20mg daily

Interventions

Hydroxychloroquine, Metformin, Sirolimus

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Dasatanib

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Dasatinib 20mg daily

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 1250mg twice daily

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 1250mg twice daily Dasatanib 20mg daily

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 2500mg twice daily

Intervention Type: COMBINATION_PRODUCT

Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib

Hydroxychloroquine 600mg twice daily Metformin 500mg daily for 7 days, then increase to 1000mg daily Sirolimus 0.5mg daily Nelfinavir 2500mg twice daily Dasatanib 20mg daily

Intervention Type: COMBINATION_PRODUCT

Eligibility Criteria

Inclusion Criteria

1. Patient must have advanced solid tumor cancer of any type (Phase I) or advanced prostate cancer (Phase II). Prostate cancer patients must have a PSA of at least 0.1 ng/mL.

2. Tissue diagnosis documented by pathology report, or clinic note attesting to same.

3. Measurable / evaluable tumor by RECIST, quantitative blood biomarker, or radionuclide imaging

4. Voluntary, signed and dated, Institutional Review Board (IRB) approved consent form in accordance with regulatory and institutional guidelines.

5. Documented progression of disease during treatment with one or more standard systemic regimens. Single or multiple regimens of chemotherapy, hormone suppression therapy, radiation therapy, surgery, immunotherapy, or adoptive cell therapy are allowed.

6. 18 years of age or older.

7. ECOG performance status of 0-2.

8. Bilirubin ≤ 1.5 times upper limit of normal (ULN) and AST / ALT ≤ 3 times ULN. Subjects with Gilbert's syndrome may be included if the total bilirubin is < 3 times ULN and the direct bilirubin is within normal limits.

9. Serum creatinine ≤ 1.5 times ULN.

10. Absolute neutrophil count (ANC) ≥ 1,000 cells / mm3

11. Platelet count ≥ 75,000 cells / mm3

12. Hemoglobin ≥ 9 g/ dL.

13. Fasting glucose ≤ 160 mg/dL or non-fasting glucose ≤ 200 mg/dL.

14. Urinalysis with no clinically significant abnormalities.

15. Adequately controlled blood pressure as determined by the treating investigator.

16. Subjects with the potential to produce children must agree to effective contraceptive method use during study participation.

17. Patients requiring narcotic analgesics must be on stable doses for at least 2 weeks prior to study entry.

18. Patients being considered for a dose level containing nelfinavir mesylate must discontinue any statin use within 48 hours of beginning study treatment.

Exclusion Criteria

1. New York Heart Association Class III or IV, cardiac disease, myocardial infarction within the past 6 months, unstable arrhythmia, or history of ischemia on ECG.

2. Underlying psychiatric disorder requiring hospitalization within the last two years.

3. Clinically significant neurological disorder (Parkinson's disease, dementia, multiple sclerosis), as determined by the enrolling investigator.

4. Active, uncontrolled bacterial, viral, or fungal infection, requiring systemic therapy.

5. Treatment with local or systemic radiation therapy, surgery, or investigational therapy within 28 days prior to registration.

6. Unwillingness or inability to comply with procedures required in this protocol.

7. Serious nonmalignant disease that could compromise protocol objectives in the opinion of the Investigator.

8. Patients who are receiving, coumadin, apixaban, argatroban or rivaroxaban.

9. Patients who are currently participating in any other clinical trial of an investigational product.

10. Any other mental incapacitation or psychiatric illness that would preclude study participation, as determined by the enrolling investigator.

11. Prisoners or patients who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical (e.g., infectious disease) illness must not be enrolled into this study.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Medical University of South Carolina

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Alan Brisendine

Role: CONTACT

brisend@musc.edu

843-792-9007

Jasmin Brooks

Role: CONTACT

brooksjm@musc.edu

Facility Contacts

Alan Brisendine

Role: primary

brisend@musc.edu

843-792-9007

Jasmin Brooks

Role: backup

brooksjm@musc.edu

Other Identifiers

103352

Identifier Type: -

Identifier Source: org_study_id