Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer

NCT ID: NCT00786682

Last Updated: 2023-08-14

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 11 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-12-31
• Study Completion Date: 2012-10-31

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Hydroxychloroquine may help docetaxel work better and kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving docetaxel together with hydroxychloroquine works in treating patients with metastatic prostate cancer.

Detailed Description

OBJECTIVES:

Primary

• To assess the antitumor activity, in terms of tumor response rate, of docetaxel in combination with hydroxychloroquine in patients with metastatic, hormone-refractory, chemotherapy-naive prostate cancer.

Secondary

• To measure time to disease progression and overall survival.
• To determine the feasibility and safety of this regimen in these patients.

OUTLINE: This is a multicenter study.

Patients receive oral hydroxychloroquine twice daily on days 1-21 and docetaxel IV over 1 hour on day 1. Treatment repeats every 21 days (up to 6 courses with docetaxel) in the absence of disease progression or unacceptable toxicity.

Conditions

Prostate Cancer

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Docetaxel and Hydroxychloroquine

Drug: Docetaxel 75 mg/m2 intravenously every 21 days on Day 1 of the treatment cycle

Drug: hydroxychloroquine 200 mg twice daily

A cycle is defined as an interval of 21 days.

Group Type: EXPERIMENTAL

docetaxel

Intervention Type: DRUG

hydroxychloroquine

Intervention Type: DRUG

Interventions

docetaxel

Intervention Type: DRUG

hydroxychloroquine

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed prostate cancer

• Metastatic disease, as demonstrated by bone scan and/or CT scan of the abdomen/pelvis
• Must demonstrate disease progression after initial hormone therapy (including bicalutamide and flutamide)
• No prior chemotherapy allowed
• No known brain metastases

PATIENT CHARACTERISTICS:

• ECOG performance status 0-1
• Life expectancy ≥ 6 months
• ANC > 1,500/μL
• Hemoglobin > 10 g/dL
• Platelet count > 100,000/mm^3
• Serum creatinine < 2.0 mg/dL or creatinine clearance > 50 mL/min
• Total bilirubin normal
• SGOT and/or SGPT < 1.5 times upper limit of normal (ULN)
• Alkaline phosphatase < 2.5 times ULN
• Fertile patients must use effective contraception during and for 3 months after completion of study therapy
• No second primary malignancy except for most in situ carcinomas (e.g., adequately treated nonmelanoma carcinoma of the skin) or other malignancy treated ≥ 5 years ago with no evidence of recurrence
• No history or symptoms of cardiovascular disease, including any of the following:

• NYHA class II-IV cardiovacular disease within the past 6 months
• Coronary artery disease
• Arrhythmias
• Conduction defects with risk of cardiovascular instability
• Uncontrolled hypertension
• Clinically significant pericardial effusion
• Congestive heart failure
• No uncontrolled intercurrent illness including ongoing active infection that would limit compliance with study requirements
• No rheumatoid arthritis or systemic lupus erythematosus requiring treatment
• No psoriasis or porphyria
• No known HIV infection
• No hypersensitivity to 4-aminoquinoline compounds, including hydroxychloroquine sulfate, chloroquine phosphate, and amodiaquine
• No retinal or vision changes from prior 4-aminoquinoline compound use
• No history of severe hypersensitivity reaction to docetaxel or other drugs formulated with polysorbate 80
• No known G-6PDH deficiency
• Neurotoxicity ≤ grade 1

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• Recovered from all prior therapy
• No prior taxane
• At least 4 weeks since prior therapy (including surgery and radiotherapy)
• At least 1 week since prior herbal supplements
• At least 6 weeks since prior bicalutamide
• At least 4 weeks since prior flutamide
• No current hydroxychloroquine for treatment or prophylaxis

• Prior hydroxychloroquine allowed
• No other concurrent investigational or commercial agents or therapies, including chemotherapy, immunotherapy, hormonal cancer therapy, radiotherapy, surgery for cancer, or experimental therapy
• Concurrent luteinizing-hormone releasing-hormone agonists allowed

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 120 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

University of Medicine and Dentistry of New Jersey

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Mark Stein, MD

Role: PRINCIPAL_INVESTIGATOR

Rutgers Cancer Institute of New Jersey

Locations

Cancer Institute of New Jersey at Hamilton

Hamilton, New Jersey, United States

Mountainside Hospital

Montclair, New Jersey, United States

Carol G. Simon Cancer Center at Morristown Memorial Hospital

Morristown, New Jersey, United States

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

New Brunswick, New Jersey, United States

St. Peters University Hospital

New Brunswick, New Jersey, United States

Overlook Hospital

Summit, New Jersey, United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

Countries

United States

Other Identifiers

P30CA072720

Identifier Type: NIH

Identifier Source: secondary_id

View Link

CINJ-080805

Identifier Type: OTHER

Identifier Source: secondary_id

CDR0000617998

Identifier Type: -

Identifier Source: org_study_id