Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study

NCT ID: NCT05036031

Last Updated: 2021-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-01

Study Completion Date

2021-10-31

Brief Summary

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The definition and diagnostic criteria of acute-on chronic liver failure (ACLF) differed evidently between the East and the West due to the difference in the underlying etiology. Liver transplantation is the most effective treatment to reverse the progress of ACLF and improve the survival rate of patients. The purpose of this study is to explore the accuracy of the two diagnostic criteria of EASL-CLIF and APASL ACLF in assessing the survival rate of patients with liver cirrhosis after LT.

Detailed Description

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A retrospective collection and analysis of the preoperative conditions of patients with LT due to cirrhosis in a single center from January 2015 to June 2020 would be conducted, including epidemiological characteristics, etiology, clinical indicators, and short-term (28 days, 90 days) and long-term (1 year, 3 years) survival after LT.

Conditions

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Acute-On-Chronic Liver Failure Liver Cirrhosis Liver Transplant; Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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EASL-CLIF ACLF patients

No interventions assigned to this group

APASL ACLF patients

No interventions assigned to this group

Non-ACLF patients

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients underwent liver transplantation for cirrhosis
* The diagnosis of ACLF followed APASL and EASL-CLIF definition.

Exclusion Criteria

* Patients with malignant tumor or underwent living donor liver transplantation (LDLT) were excluded.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RenJi Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Qiang Xia

Role: STUDY_CHAIR

Dept. Liver Surgery, Renji Hospital, School of Medicine, SJTU

Hao Feng

Role: PRINCIPAL_INVESTIGATOR

Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

Central Contacts

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Hao Feng, MD., Ph.D.

Role: CONTACT

008615000901110

Other Identifiers

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Renji-IIT2021091

Identifier Type: -

Identifier Source: org_study_id

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