Fecal Microbiota Transplantation for Liver Failure

NCT ID: NCT05170971

Last Updated: 2024-03-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-01

Study Completion Date

2026-12-31

Brief Summary

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To investigate the safety, adverse reactions and therapeutic effects of fecal microbiota transplantation on patients with liver failure;to investigate the effect of fecal microbiota transplantation on the intestinal microecology and "gut-liver axis immune system" of liver failure, and further optimization of fecal microbiota transplantation technology.

Detailed Description

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Conditions

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Liver Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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fecal microbiota transplantation

The fecal bacteria were transplanted once every 5 days for a total of 4 times.

Group Type OTHER

fecal microbiota transplantation

Intervention Type OTHER

The fecal bacteria were transplanted once every 5 days for a total of 4 times

Interventions

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fecal microbiota transplantation

The fecal bacteria were transplanted once every 5 days for a total of 4 times

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients willing to sign informed consent
* Patients aged 18-65
* According to the diagnosis standard of liver failure in the guide for diagnosis and treatment of liver failure (2018 Edition), the eligible patients are included, that is, on the basis of chronic liver disease, the syndrome with acute jaundice deepening and coagulation dysfunction as the manifestation of liver failure caused by various inducements can be combined with complications such as Hepatoencephalopathy, ascites, electrolyte disorder, infection, hepatorenal syndrome, hepatopulmonary syndrome, etc And extrahepatic organ failure. The patient's jaundice deepened rapidly, the serum TBIL ≥ 10 × ULN or the daily rise ≥ 17.1 μ mol / L; there was bleeding, PTA ≤ 40% (or INR ≥ 1.5)

Exclusion Criteria

* Patients with severe heart failure, COPD, cerebrovascular accident, nephrotic syndrome, etc;
* Patients with gastrointestinal bleeding, pulmonary infection, septicemia, etc
* Patients with liver cancer, lung cancer, lymphoma and other malignant tumors
* Patients taking anticoagulants, mental diseases and immune diseases for a long time
* Pregnant or lactating women.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ningbo Medical Center Lihuili Hospital

OTHER_GOV

Sponsor Role lead

Responsible Party

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xulanman

Head of Infection Department

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ningbo Medical Center Lihuili Hospital,Affiliated Lihuili hospital of Ningbo University

Ningbo, Zhejiang, China

Site Status RECRUITING

Countries

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China

Central Contacts

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lanman Xu

Role: CONTACT

+86 13587646315

Facility Contacts

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Xu lanman

Role: primary

+86 13587646315

Other Identifiers

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KJ2019PJ021

Identifier Type: -

Identifier Source: org_study_id

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