Swedish Microinvasive Glaucoma Surgery Study (SMIGS)

NCT ID: NCT05035394

Last Updated: 2025-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-16

Study Completion Date

2027-09-30

Brief Summary

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The purpose of the study is to investigate the efficacy of Cataract Surgery as stand-alone compared to Cataract Surgery in combination with Kahook Dual Blade Glide goniotomy (KDB) or iStent Inject W Trabecular Microbypass Stent (Istent) in eyes with Open-angle glaucoma.

Detailed Description

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Glaucoma patients with significant cataract are being informed about the study and potential risks, all participants giving written informed consent and meeting the criteria will become eligibility for study entry. Participants meeting the eligible requirements will be randomized to Cataract Surgery as stand-alone (40 patients) or Cataract Surgery combined with Kahook Dual Blade Glide (40 patients) or iStent Inject W (40 patients).

Conditions

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Open Angle Glaucoma Cataract Kahook Dual Blade Glide Istent Inject W MIGS Goniotomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Cataract surgery as stand alone

Cataract surgery as stand alone. Cataract surgery will be performed in a standardized fashion.

Group Type ACTIVE_COMPARATOR

Cataract surgery

Intervention Type PROCEDURE

Cataract Surgery in a standardized fashion

Cataract surgery in combination with Kahook Dual Blade glide goniotomy

Cataract surgery combined with Kahook Dual Blade Glide goniotomy. The goniotomy will be performed at the end of cataract surgery through the temporal cataract incision.

Group Type ACTIVE_COMPARATOR

KDB

Intervention Type PROCEDURE

Goniotomy with KDB glide will be performed at the end of Cataract Surgery

Cataract surgery in combination with iStent Inject W implantation

Cataract surgery combined with iStent Inject W. The two stents will be injected in Schlemms canal at the end of cataract surgery through the temporal cataract incision.

Group Type ACTIVE_COMPARATOR

Istent

Intervention Type PROCEDURE

Two iStent inject W will be injected into Schlemms Canal at the end of Cataract Surgery

Interventions

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Cataract surgery

Cataract Surgery in a standardized fashion

Intervention Type PROCEDURE

KDB

Goniotomy with KDB glide will be performed at the end of Cataract Surgery

Intervention Type PROCEDURE

Istent

Two iStent inject W will be injected into Schlemms Canal at the end of Cataract Surgery

Intervention Type PROCEDURE

Other Intervention Names

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Phacoemulsification Cataract Surgery as stand-alone Kahook Dual Blade Glide, New World Medical, Inc, Rancho Cucamonga, CA KDB glide iStent inject W Trabecular Micro-Bypass Stent System Model G2-W, Glaukos Corporation, San Clemente, California

Eligibility Criteria

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Inclusion Criteria

* Only one eye per participant
* Clinically significant cataract
* Glaucoma or intraocular hypertension treated with one to four medications and no need for filtering glaucoma surgery at the time of study enrollment.
* Open chamber angle with Schaffer grading three to four in at least two quadrants

Exclusion Criteria

* Previous glaucoma surgery, including cyclodestructive procedures.
* Selective Laser Trabeculoplasty (SLT) within 90 days prior to planned surgery.
* Exudative age-related macular degeneration, proliferative diabetic retinopathy, clinically significant corneal dystrophy, other eye disease that affect intraocular eye pressure or visual field.
* Unable to participate and make written consent due to another medical condition.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Umeå University

OTHER

Sponsor Role lead

Responsible Party

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Anna Barkander

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anna Barkander, MD

Role: PRINCIPAL_INVESTIGATOR

Hospital of Ostersund, department of Ophtalmology

Locations

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Eye clinic at the hospital of Ostersund

Östersund, Östersund, Sweden

Site Status

Countries

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Sweden

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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2021-02970

Identifier Type: -

Identifier Source: org_study_id

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