A Study of the Trabecular Micro-bypass Stent in Combination With Cataract Surgery in Subjects With Open Angle Glaucoma

NCT ID: NCT00323284

Last Updated: 2018-01-12

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-06-30

Study Completion Date

2010-03-31

Brief Summary

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The purpose of this study is to evaluate the safety and efficacy of the iStent trabecular micro-bypass stent in reducing intraocular pressure (IOP) in subjects with open-angle glaucoma or ocular hypertension and co-existing cataract.

Detailed Description

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The purpose of this study is to evaluate the safety and efficacy of the iStent trabecular micro-bypass stent in reducing intraocular pressure (IOP) in subjects with open-angle glaucoma or ocular hypertension and co-existing cataract. Pre-operative unmedicated baseline pressures will be compared with post operative values in both study arms.

Conditions

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Open-Angle Glaucoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors
IOP measurement

Study Groups

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A--iStent plus Cataract Surgery

iStent plus Cataract Surgery

Group Type ACTIVE_COMPARATOR

iStent plus Cataract Surgery

Intervention Type DEVICE

ab interno trabecular bypass stent surgery

B--Cataract Surgery Only

Cataract Surgery only

Group Type ACTIVE_COMPARATOR

Cataract surgery only

Intervention Type PROCEDURE

Cataract surgery only

Interventions

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iStent plus Cataract Surgery

ab interno trabecular bypass stent surgery

Intervention Type DEVICE

Cataract surgery only

Cataract surgery only

Intervention Type PROCEDURE

Other Intervention Names

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iStent Surgery Phacoemulsification

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with open-angle glaucoma (OAG) in the study eye. Pseudoexfoliative and pigmentary glaucoma are also acceptable diagnoses.
* Subject on at least one glaucoma medication
* Able and willing to attend follow up visits for two years post operative
* Able and willing to sign informed consent

Exclusion Criteria

* Prior glaucoma procedures (eg trabeculectomy, viscocanalostomy, ALT, SLT, shunt implant, collagen implant, cyclo destructive procedures etc)
* Angle closure glaucoma
* Fellow eye already enrolled
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Glaukos Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jeff Wells, PharmD, MBA

Role: STUDY_DIRECTOR

Glaukos Corporation

Locations

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Assil Eye Institute

Beverly Hills, California, United States

Site Status

North Bay Eye Associates Inc

Petaluma, California, United States

Site Status

Ellison Ambulatory Care Center

Sacramento, California, United States

Site Status

Harvard Eye Associates

San Clemente, California, United States

Site Status

Shepard Eye Center

Santa Maria, California, United States

Site Status

Glaucoma Consultants of Colorado

Littleton, Colorado, United States

Site Status

Florida Eye Microsurgical Institute, Inc.

Boynton Beach, Florida, United States

Site Status

The Center for Excellence in Eye Care

Miami, Florida, United States

Site Status

International Eye Center

Tampa, Florida, United States

Site Status

Clayton Eye Center

Morrow, Georgia, United States

Site Status

Indiana University

Indianapolis, Indiana, United States

Site Status

Stiles Eyecare Excellence

Overland Park, Kansas, United States

Site Status

The Eye Care Institute Building

Louisville, Kentucky, United States

Site Status

Williamson Nelson Eye Center

Baton Rouge, Louisiana, United States

Site Status

Kresge Eye Institute

Detroit, Michigan, United States

Site Status

Great Lakes Eye Care

Saint Joseph, Michigan, United States

Site Status

Chu Vision Institute

Edina, Minnesota, United States

Site Status

University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

Discover Vision Centers

Independence, Missouri, United States

Site Status

Silverstein Eye Centers

Kansas City, Missouri, United States

Site Status

The Shepherd Eye Center

Las Vegas, Nevada, United States

Site Status

Glaucoma Consultants of Capital Region

Slingerlands, New York, United States

Site Status

Donald J. Digby and Associates

Greensboro, North Carolina, United States

Site Status

James Branch MD

Winston-Salem, North Carolina, United States

Site Status

Cinicinnati Eye Institute

Cincinnati, Ohio, United States

Site Status

Laurel Eye Center

Brookville, Pennsylvania, United States

Site Status

Wills Eye Hospital

Philadelphia, Pennsylvania, United States

Site Status

Associates in Ophthalmology

Pittsburgh, Pennsylvania, United States

Site Status

UPMC Eye Center

Pittsburgh, Pennsylvania, United States

Site Status

Southeast Texas Medical Association, L.L.P.

Beaumont, Texas, United States

Site Status

Countries

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United States

References

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Samuelson TW, Katz LJ, Wells JM, Duh YJ, Giamporcaro JE; US iStent Study Group. Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract. Ophthalmology. 2011 Mar;118(3):459-67. doi: 10.1016/j.ophtha.2010.07.007. Epub 2010 Sep 15.

Reference Type RESULT
PMID: 20828829 (View on PubMed)

Craven ER, Katz LJ, Wells JM, Giamporcaro JE; iStent Study Group. Cataract surgery with trabecular micro-bypass stent implantation in patients with mild-to-moderate open-angle glaucoma and cataract: two-year follow-up. J Cataract Refract Surg. 2012 Aug;38(8):1339-45. doi: 10.1016/j.jcrs.2012.03.025.

Reference Type RESULT
PMID: 22814041 (View on PubMed)

Other Identifiers

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GC-003

Identifier Type: -

Identifier Source: org_study_id

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