GTS400 Stent Implantation in Conjunction With Cataract Surgery in Subjects With Open-angle Glaucoma

NCT ID: NCT01052558

Last Updated: 2015-05-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

164 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2013-12-31

Brief Summary

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The purpose of this study is to evaluate the safety and efficacy of the GTS400 trabecular micro-bypass stent in reducing intraocular pressure (IOP) in subjects with open-angle glaucoma or ocular hypertension and co-existing cataract.

Detailed Description

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Glaucoma is a collection of disorders characterized by progressive loss of visual field due to optic nerve damage. It is a leading cause of blindness in the United States, affecting 1-2% of individuals aged 60 and over. Management of glaucoma requires chronic, life-long treatment with a spectrum of therapeutic options including medications, laser treatment and surgical implants. The common goal among the various therapies is to lower intraocular pressure to target levels in order to prevent loss of visual fields from excessive pressure on the optic nerve.

Conditions

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Glaucoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Cataract Surgery Only

Group Type ACTIVE_COMPARATOR

Cataract Surgery

Intervention Type PROCEDURE

Subjects will be randomized to one of two groups. In this case, subjects will undergo cataract surgery only.

Treatment with Cataract Surgery & Stents

Ab interno trabecular micro-bypass stent surgery

Group Type EXPERIMENTAL

iStent Inject (GTS400)

Intervention Type DEVICE

Subjects will be randomized to one of two groups. In this case, subjects will undergo cataract surgery with subsequent implantation of GTS400 stents.

Interventions

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iStent Inject (GTS400)

Subjects will be randomized to one of two groups. In this case, subjects will undergo cataract surgery with subsequent implantation of GTS400 stents.

Intervention Type DEVICE

Cataract Surgery

Subjects will be randomized to one of two groups. In this case, subjects will undergo cataract surgery only.

Intervention Type PROCEDURE

Other Intervention Names

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Cataract surgery, stent implantation

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with open-angle glaucoma in the study eye
* Subject must be on 1 to 3 glaucoma medications
* Subject able and willing to attend follow up visits for two years postop
* Subject able and willing to sign informed consent

Exclusion Criteria

* Pseudoexfoliative and pigmentary glaucoma
* Prior glaucoma surgery of any type
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Glaukos Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jeff Wells, PharmD, MBA

Role: STUDY_DIRECTOR

Glaukos Corporation

Jay Katz, MD

Role: STUDY_CHAIR

Wills Eye Institute; Thomas Jefferson University

Locations

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Boozman-Hof Regional Eye Clinic

Rogers, Arkansas, United States

Site Status

North Bay Eye Associates, Inc.

Petaluma, California, United States

Site Status

Glaucoma Consultants of Colorado

Parker, Colorado, United States

Site Status

The Center for Excellence in Eye Care

Miami, Florida, United States

Site Status

International Eye Center

Tampa, Florida, United States

Site Status

Clayton Eye Center / Eye Care Centers Management, Inc.

Morrow, Georgia, United States

Site Status

Chicago Eye Specialists

Chicago, Illinois, United States

Site Status

Whitson Vision, PC

Indianapolis, Indiana, United States

Site Status

D'Ambrosio Eye Care

Lancaster, Massachusetts, United States

Site Status

Kresge Eye Institute

Detroit, Michigan, United States

Site Status

Discover Vision Centers

Independence, Missouri, United States

Site Status

Silverstein Eye Centers

Kansas City, Missouri, United States

Site Status

St. John's Medical Research Institute

Springfield, Missouri, United States

Site Status

Las Vegas Physician Research Group

Henderson, Nevada, United States

Site Status

Shepherd Eye Center

Las Vegas, Nevada, United States

Site Status

Ophthalmic Consultants of Long Island

Rockville Centre, New York, United States

Site Status

Thomas Mundorf, MD

Charlotte, North Carolina, United States

Site Status

Laurel Eye Clinic

Brookville, Pennsylvania, United States

Site Status

Carolina Eyecare Physicians

Mt. Pleasant, South Carolina, United States

Site Status

Vance Thompson Vision / Sanford Clinic

Sioux Falls, South Dakota, United States

Site Status

Texan Eye

Austin, Texas, United States

Site Status

Lehmann Eye Center

Nacogdoches, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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GC-006

Identifier Type: -

Identifier Source: org_study_id

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