Evaluate the Safety and Effectiveness of iSTAR Medical's MINIject™ Implant for Lowering Intraocular Pressure (IOP) in Subjects With Primary Open-angle Glaucoma.

NCT ID: NCT05024695

Last Updated: 2025-09-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

975 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-19

Study Completion Date

2029-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Evaluate the safety and effectiveness of iSTAR Medical's MINIject™ implant for lowering intraocular pressure (IOP) in subjects with primary open-angle glaucoma.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This is a prospective, multicenter, masked clinical trial to evaluate the safety and effectiveness of iSTAR Medical's MINIject™ implant for lowering intraocular pressure (IOP) in subjects with primary open-angle glaucoma.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Glaucoma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Person(s) checking intraocular pressures are masked, except for day of surgery, throughout the duration of the trial.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Implant Group

Group Type EXPERIMENTAL

MINIject™ Implant

Intervention Type DEVICE

The MINIject™ SO627 is an integrated system for Minimally Invasive Glaucoma Surgery (MIGS) comprised of a glaucoma drainage implant, the MINIject™ SO627 and the SO Delivery System, designed to deliver the MINIject™ implant into the supraciliary space.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

MINIject™ Implant

The MINIject™ SO627 is an integrated system for Minimally Invasive Glaucoma Surgery (MIGS) comprised of a glaucoma drainage implant, the MINIject™ SO627 and the SO Delivery System, designed to deliver the MINIject™ implant into the supraciliary space.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Males and females, 46 years of age or older
* A diagnosis of primary open-angle glaucoma, who are candidates for medical therapy, laser treatment, or glaucoma-filtering surgery
* Pseudophakic with prior uncomplicated cataract surgery

Exclusion Criteria

* Angle closure, congenital, or secondary glaucoma
* Diagnosed degenerative visual disorders
* Clinically significant intraocular inflammation or infection
Minimum Eligible Age

46 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

iSTAR Medical

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Sabine Glibert

Role: STUDY_DIRECTOR

iSTAR Medical

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Arizona Advanced Eye Research Institute

Glendale, Arizona, United States

Site Status

Vold Vision

Fayetteville, Arkansas, United States

Site Status

Beverly Hills Institute of Ophthalmology

Beverly Hills, California, United States

Site Status

Reeve Woods Eye Center

Chico, California, United States

Site Status

Sacramento Eye Consultants, A Medical Corporation

Sacramento, California, United States

Site Status

Grand Junction Eye Care

Grand Junction, Colorado, United States

Site Status

Eye Associates of Fort Myers

Fort Myers, Florida, United States

Site Status

Intermountain Eye Center

Eagle, Idaho, United States

Site Status

Illinois Eye Center

Peoria, Illinois, United States

Site Status

Virdi Eye Clinic

Rock Island, Illinois, United States

Site Status

Stiles Eyecare Excellene and Glaucoma Institute

Overland Park, Kansas, United States

Site Status

LA Eye and Laser

Alexandria, Louisiana, United States

Site Status

Minnesota Eye Consultants

Bloomington, Minnesota, United States

Site Status

Eye Consultants PC

Omaha, Nebraska, United States

Site Status

Center for Sight Las Vegas

Las Vegas, Nevada, United States

Site Status

NYU Langone Ophthalmology

New York, New York, United States

Site Status

Apex Eye Clinical Research, LLC

Mason, Ohio, United States

Site Status

Oklahoma Eye Surgeons

Oklahoma City, Oklahoma, United States

Site Status

Vanderbilt Eye Institute

Nashville, Tennessee, United States

Site Status

Glaucoma Associates of Texas

Dallas, Texas, United States

Site Status

El Paso Eye Surgeons

El Paso, Texas, United States

Site Status

Ophthalmology Associates

Fort Worth, Texas, United States

Site Status

Houston Eye Associates

Houston, Texas, United States

Site Status

Berkeley Eye Center

Houston, Texas, United States

Site Status

R and R Eye Research

San Antonio, Texas, United States

Site Status

The Eye Institute of Utah

Salt Lake City, Utah, United States

Site Status

Spokane Eye Clinical Research

Spokane, Washington, United States

Site Status

Eye Centers of Racine and Kenosha

Kenosha, Wisconsin, United States

Site Status

Prism Eye Institute

Oakville, Ontario, Canada

Site Status

The Institute de l'Oeil des Laurentides

Boisbriand, Quebec, Canada

Site Status

Clinique Opthalmologies Bellevue

Montreal, , Canada

Site Status

Swiss Glaucoma Research Foundation Swiss Visio Montchoisi

Lausanne, , Switzerland

Site Status

Queen Victoria Hospital NHS Foundation Trust

East Grinstead, , United Kingdom

Site Status

Glaucoma Service Moorfields Eye Hospital

London, , United Kingdom

Site Status

Imperial College Healthcare NHS Trust Western Eye Hospital

London, , United Kingdom

Site Status

KCL Frost Eye Research Department St Thomas' Hospital

London, , United Kingdom

Site Status

Research & Development Unit, Learning and Research Centre (LaRC), York Hospital

York, , United Kingdom

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Canada Switzerland United Kingdom

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ISM06 (STAR-V)

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.