Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline

NCT ID: NCT05014893

Last Updated: 2025-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-06

Study Completion Date

2026-12-31

Brief Summary

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This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.

Detailed Description

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Cognitive assessment tools are used to assess cognitive function of subjects in different cities. Functional and structural MRI and EEG are applied to investigate the neural mechanisms of cognitive function decline and effects of methods to improve and restore cognitive function.

Conditions

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Mild Cognitive Impairment (MCI) Subjective Cognitive Decline (SCD) Aging Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SCREENING

Blinding Strategy

SINGLE

Participants

Study Groups

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Control

Control group, without specific treatments

Group Type NO_INTERVENTION

No interventions assigned to this group

Cognitive training

This group receives treatments to improve cognitive function.

Group Type EXPERIMENTAL

multi-modal targeted intervention (e.g., cognitive training, exercise, games)

Intervention Type COMBINATION_PRODUCT

The Intervention group will be given recommended interventions tailored to individuals based on their risks (e.g., physical exercise programs, cognitive training, dietary advice, control of blood pressure and cholesterol, healthy diet, control obesity, stop smoking,reduce alcohol excess)

Interventions

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multi-modal targeted intervention (e.g., cognitive training, exercise, games)

The Intervention group will be given recommended interventions tailored to individuals based on their risks (e.g., physical exercise programs, cognitive training, dietary advice, control of blood pressure and cholesterol, healthy diet, control obesity, stop smoking,reduce alcohol excess)

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

* Adults being able to walk at least a block, and
* Adults with subjective cognitive decline (SCD), or
* Adults with mild cognitive impairment (MCI), or
* Adults with normal cognitive function

Exclusion Criteria

* Clinical diagnosis of dementia
* Adults who cannot follow the protocal
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nanjing Brain Hospital

UNKNOWN

Sponsor Role collaborator

The Third People's Hospital of Yunnan Province

OTHER_GOV

Sponsor Role collaborator

Central South University

OTHER

Sponsor Role collaborator

Beijing academy of science and technology

UNKNOWN

Sponsor Role collaborator

Beijing University of Chinese Medicine

OTHER

Sponsor Role collaborator

National Research Center for Rehabilitation Technical Aids

OTHER

Sponsor Role lead

Responsible Party

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Pengxu Wei

Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Pengxu Wei

Role: PRINCIPAL_INVESTIGATOR

National Research Center for Rehabilitation Technical Aids

Locations

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National Research Center for Rehabilitation Technical Aids

Beijing, Beijing Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Ying Wang

Role: CONTACT

1058122921

Facility Contacts

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Ying Wang

Role: primary

1059122921

Other Identifiers

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201900045

Identifier Type: -

Identifier Source: org_study_id

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