A Study to Evaluate the Efficacy and Safety of Proxalutamide (GT0918) in Hospitalized COVID-19 Subjects

NCT ID: NCT05009732

Last Updated: 2023-08-18

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE3
• Total Enrollment: 139 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-09-30
• Study Completion Date: 2023-07-14

Brief Summary

This study is an adaptive Phase III randomized double-blind placebo-controlled trial to evaluate the efficacy and safety of Proxalutamide (GT0918) in hospitalized adults diagnosed with COVID-19. The study is a multicenter trial that will be conducted globally. The study will compare GT0918 plus standard of care (SOC) with the placebo plus SOC. Approximately 762 subjects will be randomized in a 1:1 ratio to either GT0918 plus SOC or placebo plus SOC group.

Detailed Description

Coronavirus disease 2019 (COVID-19) emerged in late 2019 and spread rapidly, resulting in a global pandemic.SARS-CoV-2 encodes nonstructural and structural proteins required for its viral life cycle. Among them, the spike glycoprotein plays a pivotal role in SARS-CoV-2 infection by recognizing and attaching to ACE2 transmembrane protein on host cells. Kintor protocol has been designed to evaluate efficacy and safety of GT0918 in hospitalized subjects with COVID-19 illness. The target population of this study are hospitalized subjects with COVID-19 illness with positive SARS-CoV-2 virus test within 72 hours of randomization. The study will evaluate anti-androgen therapy may effectively prevent progression to the more severe form of COVID-19 illness and death, shorten the time to sustained recovery and decrease the mortality rate. Subject will receive either GT0918 plus standard of care or matched placebo plus standard of care. GT0918/placebo will be given 300mg orally once a day around 30 minutes after meal for 7 days and can be extended up to 14 days per investigator discretion

Conditions

Covid19

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Proxalutamide (GT0918) plus standard of care

Participants receive 300mg once daily orally plus standard of care for 7 days and can be extended up to 14 days per investigator discretion

Group Type: EXPERIMENTAL

GT0918

Intervention Type: DRUG

300mg once daily orally

Standard of care

Intervention Type: DRUG

Local standard of care per written policies or guidelines

Placebo plus standard of care

Participants will receive placebo tablets matching Proxalutamide (GT0918) orally plus standard of care for 7 days and can be extended up to 14 days per investigator discretion

Group Type: PLACEBO_COMPARATOR

Standard of care

Intervention Type: DRUG

Local standard of care per written policies or guidelines

Matching placebo

Intervention Type: DRUG

Matching placebo

Interventions

GT0918

300mg once daily orally

Intervention Type: DRUG

Standard of care

Local standard of care per written policies or guidelines

Intervention Type: DRUG

Matching placebo

Matching placebo

Intervention Type: DRUG

Other Intervention Names

Proxalutamide; SoC; Placebo

Eligibility Criteria

Inclusion Criteria

1. Subject (or legally authorized representative) provides informed consent prior to initiation of any study procedures.

2. Subject (or legally authorized representative) understands and agrees to comply with planned study procedures.

3. Male and non-pregnant female subjects with age ≥18 years of age at the time of randomization.

4. Admitted to a hospital with symptoms suggestive of severe COVID-19.

5. Has laboratory-confirmed SARS-CoV-2 infection as determined by PCR or other commercial or public health assay (including rapid antigen test) in any specimen, as documented by either of the following:

• PCR positive in sample collected < 72 hours prior to randomization; OR
• PCR positive in sample collected ≥ 72 hours prior to randomization, documented inability to obtain a repeat sample (e.g. due to lack of testing supplies, limited testing capacity, results taking > 24 hours, etc) AND progressive disease suggestive of ongoing SARS-CoV-2 infection.

6. Illness of any duration, and at least one of the following:

• Shortness of breath, RR≥30 /minute
• Clinical signs indicative of progressive aggravation, lung radiographic infiltrates by imaging (chest x-ray, CT scan, etc.) showing >50% progression within 24-48 hours
• PaO2/FiO≤300mmHg 1mmHg=0.133kPa
• Resting state SpO2 ≤ 93% on room air

7. All women of childbearing potential defined as any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) and is not postmenopausal. Highly effective contraception methods include:

• Total Abstinence (when this is in line with the preferred and usual lifestyle of the patient. Periodic abstinence (e.g. calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception, or
• Use of one of the following combinations (a+b or a+c or b+c):

1. Use of oral, injected or implanted hormonal methods of contraception or other forms of hormonal contraception that have comparable efficacy (failure rate < 1%), for example hormone vaginal ring or transdermal hormone contraception.

2. Placement of an intrauterine device (IUD) or intrauterine system (IUS);

3. Barrier methods of contraception: Condom or Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/vaginal suppository;

• Female sterilization (have had prior surgical bilateral oophorectomy with or without hysterectomy) or tubal ligation at least six weeks before taking study treatment. In case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow-up hormone level assessment;
• Male sterilization (at least 6 months prior to screening). For female subjects on the study, the vasectomized male partner should be the sole partner for that subject;
• In case of use of oral contraception women should have been stable for a minimum of 3 months before taking study treatment. Women are considered post-menopausal and not of childbearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy) or tubal ligation at least six weeks ago. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment, is she considered not of childbearing potential;

8. Regardless of their fertility status, male subjects must agree to either remain abstinent (if this is their preferred and usual lifestyle) or use condoms as well as one additional highly effective method of contraception (less than 1% failure rate) or effective method of contraception with nonpregnant women of childbearing potential partners for the duration of the study and until 90 days after the last dose. A condom is required to be used also by vasectomized men in order to prevent delivery of the drug via seminal fluid.

9. Agree not to participate in another clinical trial for the treatment of COVID-19 through Day 60 after first dose.

Exclusion Criteria

Subjects are excluded from the study if any of the following criteria apply:

1. ALT/AST > 3 times the upper limit of normal.

2. Serum total bilirubin > 1.5 x ULN (upper limit of normal)

3. Estimated glomerular filtration rate (eGFR) < 30 ml/min (including patients receiving hemodialysis or hemofiltration).

4. Subjects with significant cardiovascular disease as following:

i. heart failure NYHA class ≥3 ii. left ventricular ejection fraction <50% iii. those with a history of cardiac arrhythmias, including long QT syndrome.

5. Neutropenia (absolute neutrophil count <1000 cells/μL) (<1.0 x 10^3/μL).

6. Lymphopenia (absolute lymphocyte count <200 cells/μL) (<0.20 x 10^3/μL)

7. Pregnancy or breast feeding

8. Anticipated discharge from the hospital or transfer to another hospital which is not a study site within 72 hours.

9. Allergy to any study medication.

10. Received monoclonal antibody, convalescent plasma, or intravenous immunoglobulin [IVIg]) for COVID-19 withing 14 days of screening.

11. Suspected serious, active bacterial, fungal, viral, or other infection (besides COVID-19) that in the opinion of the investigator could constitute a risk when taking investigational product.

12. Have a history of VTE (deep vein thrombosis [DVT] or pulmonary embolism [PE]) within 12 weeks prior to screening or have a history of recurrent (>1) VTE (DVT/PE).

13. Subject taking or had taken an anti-androgen of any type including androgen depravation therapy, 5-alpha reductase inhibitors, etc. within 3 months before dosing.

14. Have participated, within the last 30 days before dosing, in a clinical study involving an investigational intervention. If the previous investigational intervention has a long half-life, 5 half-lives or 30 days, whichever is longer, should have passed.

15. Subjects with active myopathy

16. Is admitted to Intensive Care Units at randomization

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Suzhou Kintor Pharmaceutical Inc,

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Alternative Research Associates LLC.

Hialeah, Florida, United States

Sparrow Hospital

Lansing, Michigan, United States

Hannibal Clinic (HC)

Hannibal, Missouri, United States

Raymond G. Murphy VA Medical Center

Albuquerque, New Mexico, United States

Saint Lawrence Health System

New York, New York, United States

Ascension St. John Medical Center

Tulsa, Oklahoma, United States

Medical City Fort Worth

Fort Worth, Texas, United States

PRX Research

Mesquite, Texas, United States

Shanghai Public Health Clinical Center

Zhujing, Shanghai Municipality, China

The Third People's Hospital of Shenzhen

Longgang, Shenzhen, China

Beijing Ditan Hospital Capital Medical University

Beijing, , China

Davao Doctors Hospital

Davao City, Davao Region, Philippines

St. Paul's Hospital

Iloilo City, Iloilo, Philippines

Philippine General Hospital

Malina, Metro Malina, Philippines

Mary Johnston Hospital (MJH)

Manila, National Capital Region, Philippines

Quirino Memorial Medical Center

Quezon City, National Capital Region, Philippines

Lung Center of the Philippines

Quezon City, , Philippines

Johese Clinical Research: Unitas

Centurion, , South Africa

Drs Sarvan and Moodley

Durban, , South Africa

TASK Eden

George, , South Africa

Johese Clinical Research ZAH

Pretoria, , South Africa

Dr JM Engelbrecht Practice, Vergelegen Mediclinic

Somerset, , South Africa

Clinical Projects Research

Worcester, , South Africa

Communal Noncommercial Profit

Dnipro, Dnipro Oblast, Ukraine

Ivano-Frankivsk Clinical Regional Infectious Diseases Hospital

Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine

Kharkiv city clinical hospital #13

Kharkiv, Kharkivs’ka Oblast’, Ukraine

CNE of Kharkov RC Reg Cl Infectious Hospital

Kharkiv, Kharkivs’ka Oblast’, Ukraine

City Clinical infectious Hospital

Odesa, Odesa Oblast, Ukraine

Poltava Regional Clinical

Poltava, Poltava Oblast, Ukraine

CCH #1 Vinnytsia M.I.Pyrogov NMU Ch of Infectious Diseases

Vinnytsia, Vinnytsia Oblast, Ukraine

Countries

United States; China; Philippines; South Africa; Ukraine

Other Identifiers

GT0918-US-3002

Identifier Type: -

Identifier Source: org_study_id